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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P10153
No. Gene UniProt ID Protein Name Pathway PDB
1 RNASE2 P10153 Non-secretory ribonuclease NA 1GQV; 1HI2; 1HI3; 1HI4; 1HI5; 1K2A; 2BEX; 2BZZ; 2C01; 2C02; 2C05; 5E13

2 known interactions (drugs) of input target (RNASE2): Non-secretory ribonuclease
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Experimental SmallMoleculeDrug DB02098 Adenosine-2'-5'-Diphosphate Thumb
2 Experimental SmallMoleculeDrug DB01812 Adenosine-3'-5'-Diphosphate Thumb

20 predicted interactions (drugs) of input target (RNASE2): Non-secretory ribonuclease
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
Vet approved
SmallMoleculeDrug DB04272 Citric Acid Thumb 31.0%
2 Approved;
SmallMoleculeDrug DB12010 Fostamatinib Thumb 29.9%
3 Approved;
BiotechDrug DB00055 Drotrecogin alfa Thumb 19.0%
4 Experimental SmallMoleculeDrug DB02902 3'-Phosphate-Adenosine-5'-Phosphate Sulfate Thumb 17.2%
5 Experimental SmallMoleculeDrug DB04464 N-Formylmethionine Thumb 15.1%
6 Experimental SmallMoleculeDrug DB02987 Cysteine-S-Acetamide Thumb 14.3%
7 Approved BiotechDrug DB00099 Filgrastim Thumb 14.2%
8 Approved;
SmallMoleculeDrug DB00143 Glutathione Thumb 14.0%
9 Experimental SmallMoleculeDrug DB04510 3-phospho-D-glyceric acid Thumb 14.0%
10 Experimental SmallMoleculeDrug DB02363 2'-Monophosphoadenosine-5'-Diphosphate Thumb 14.0%
11 Experimental SmallMoleculeDrug DB03186 U-Pi-a-Pi Thumb 13.8%
12 Approved;
SmallMoleculeDrug DB00128 L-Aspartic Acid Thumb 13.6%
13 Approved SmallMoleculeDrug DB06739 Seratrodast Thumb 13.6%
14 Experimental SmallMoleculeDrug DB03900 2-Methyl-2-Propanol Thumb 13.6%
15 Approved;
SmallMoleculeDrug DB11994 Diacerein Thumb 13.6%
16 Experimental SmallMoleculeDrug DB07853 [4-({4-[(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO]QUINAZOLIN-2-YL}IMINO)CYCLOHEXA-2,5-DIEN-1-YL]ACETONITRILE Thumb 13.4%
17 Approved;
SmallMoleculeDrug DB09301 Chondroitin sulfate Thumb 13.2%
18 Approved;
SmallMoleculeDrug DB00173 Adenine Thumb 13.0%
19 Investigational SmallMoleculeDrug DB05961 PPL-100 Thumb 12.7%
20 Experimental SmallMoleculeDrug DB03765 2'-cytidylic acid Thumb 12.6%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.