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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P39905
No. Gene UniProt ID Protein Name Pathway PDB
1 GDNF P39905 Glial cell line-derived neurotrophic factor NA 2V5E; 3FUB; 4UX8

1 known interactions (drugs) of input target (GDNF): Glial cell line-derived neurotrophic factor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Approved;
SmallMoleculeDrug DB09301 Chondroitin sulfate Thumb

20 predicted interactions (drugs) of input target (GDNF): Glial cell line-derived neurotrophic factor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
SmallMoleculeDrug DB09130 Copper Thumb 23.4%
2 Approved;
SmallMoleculeDrug DB01593 Zinc Thumb 20.0%
3 Approved SmallMoleculeDrug DB01055 Mimosine Thumb 19.2%
4 Experimental SmallMoleculeDrug DB01812 Adenosine-3'-5'-Diphosphate Thumb 18.5%
5 Approved BiotechDrug DB08885 Aflibercept Thumb 18.1%
6 Experimental SmallMoleculeDrug DB04464 N-Formylmethionine Thumb 18.0%
7 Approved;
SmallMoleculeDrug DB00151 L-Cysteine Thumb 16.9%
8 Approved;
SmallMoleculeDrug DB06151 Acetylcysteine Thumb 15.8%
9 Experimental SmallMoleculeDrug DB08437 Puromycin Thumb 15.0%
10 Experimental SmallMoleculeDrug DB04672 cyclic 3',5'-thymidine monophosphate Thumb 14.3%
11 Illicit;
SmallMoleculeDrug DB05047 CX717 Thumb 14.3%
12 Approved SmallMoleculeDrug DB01120 Gliclazide Thumb 14.2%
13 Approved;
BiotechDrug DB00112 Bevacizumab Thumb 13.8%
14 Approved SmallMoleculeDrug DB00493 Cefotaxime Thumb 12.8%
15 Approved SmallMoleculeDrug DB00480 Lenalidomide Thumb 12.7%
16 Approved;
SmallMoleculeDrug DB00139 Succinic acid Thumb 12.3%
17 Experimental SmallMoleculeDrug DB02494 Alpha-Hydroxy-Beta-Phenyl-Propionic Acid Thumb 12.3%
18 Approved;
SmallMoleculeDrug DB00121 Biotin Thumb 11.8%
19 Investigational SmallMoleculeDrug DB05961 PPL-100 Thumb 11.6%
20 Approved SmallMoleculeDrug DB00873 Loteprednol Thumb 11.4%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.