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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P55157
No. Gene UniProt ID Protein Name Pathway PDB
1 MTTP P55157 Microsomal triglyceride transfer protein large subunit hsa04975 NA


4 known interactions (drugs) of input target (MTTP): Microsomal triglyceride transfer protein large subunit
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Investigational SmallMoleculeDrug DB04852 Implitapide Thumb
2 Approved;
Investigational		 SmallMoleculeDrug DB08827 Lomitapide Thumb
3 Investigational SmallMoleculeDrug DB05678 SLx-4090 Thumb
4 Approved SmallMoleculeDrug DB01094 Hesperetin Thumb


20 predicted interactions (drugs) of input target (MTTP): Microsomal triglyceride transfer protein large subunit
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Experimental SmallMoleculeDrug DB09207 AS-8112 Thumb 19.7%
2 Approved;
Investigational		 SmallMoleculeDrug DB08809 Dichloroacetic Acid Thumb 18.7%
3 Experimental;
Investigational		 SmallMoleculeDrug DB08838 Agmatine Thumb 18.3%
4 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00143 Glutathione Thumb 18.0%
5 Experimental SmallMoleculeDrug DB02494 Alpha-Hydroxy-Beta-Phenyl-Propionic Acid Thumb 17.9%
6 Approved;
Investigational		 SmallMoleculeDrug DB00890 Dienestrol Thumb 17.7%
7 Approved;
Investigational		 BiotechDrug DB00030 Insulin Human Thumb 17.6%
8 Approved;
Withdrawn		 SmallMoleculeDrug DB04824 Phenolphthalein Thumb 17.4%
9 Approved;
Investigational		 SmallMoleculeDrug DB00358 Mefloquine Thumb 17.3%
10 Experimental SmallMoleculeDrug DB01717 Bis(Adenosine)-5'-Pentaphosphate Thumb 17.0%
11 Approved;
Nutraceutical;
Vet approved		 SmallMoleculeDrug DB00162 Vitamin A Thumb 17.0%
12 Nutraceutical SmallMoleculeDrug DB00116 Tetrahydrofolic acid Thumb 16.8%
13 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00755 Tretinoin Thumb 16.5%
14 Investigational SmallMoleculeDrug DB12695 Phenethyl Isothiocyanate Thumb 16.4%
15 Investigational SmallMoleculeDrug DB05467 R667 Thumb 16.2%
16 Investigational SmallMoleculeDrug DB04893 AZD3409 Thumb 16.1%
17 Experimental SmallMoleculeDrug DB08499 N-[3-(2-fluoroethoxy)phenyl]-N'-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-6-yl)butanediamide Thumb 15.9%
18 Approved SmallMoleculeDrug DB09371 Norethynodrel Thumb 15.8%
19 Approved;
Vet approved		 SmallMoleculeDrug DB00257 Clotrimazole Thumb 15.4%
20 Approved SmallMoleculeDrug DB00977 Ethinyl Estradiol Thumb 15.3%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.