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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P00747
No. Gene UniProt ID Protein Name Pathway PDB
1 PLG P00747 Plasminogen hsa04080; hsa04610; hsa05150; hsa05164


13 known interactions (drugs) of input target (PLG): Plasminogen
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image
1 Approved;
Investigational;
Withdrawn
BiotechDrug DB00013 Urokinase Thumb
2 Approved BiotechDrug DB00029 Anistreplase Thumb
3 Approved BiotechDrug DB00009 Alteplase Thumb
4 Approved;
Investigational
BiotechDrug DB00086 Streptokinase Thumb
5 Approved;
Investigational
SmallMoleculeDrug DB09130 Copper Thumb
6 Approved;
Investigational;
Withdrawn
BiotechDrug DB06692 Aprotinin Thumb
7 Approved SmallMoleculeDrug DB00302 Tranexamic Acid Thumb
8 Approved;
Investigational
BiotechDrug DB00015 Reteplase Thumb
9 Approved BiotechDrug DB00031 Tenecteplase Thumb
10 Experimental SmallMoleculeDrug DB03709 Bicine Thumb
11 Approved;
Investigational
SmallMoleculeDrug DB00513 Aminocaproic Acid Thumb
12 Investigational SmallMoleculeDrug DB12831 Gabexate Thumb
13 Investigational BiotechDrug DB04925 Desmoteplase Thumb


20 predicted interactions (drugs) of input target (PLG): Plasminogen
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
Investigational
SmallMoleculeDrug DB01593 Zinc Thumb 71.7%
2 Investigational BiotechDrug DB06245 Lanoteplase Thumb 43.0%
3 Investigational BiotechDrug DB05254 Fibrinolysin Thumb 38.6%
4 Approved;
Investigational;
Nutraceutical
SmallMoleculeDrug DB00143 Glutathione Thumb 32.8%
5 Approved;
Investigational
SmallMoleculeDrug DB11638 Artenimol Thumb 31.2%
6 Approved;
Investigational
BiotechDrug DB09228 Conestat alfa Thumb 30.0%
7 Investigational;
Withdrawn
SmallMoleculeDrug DB00197 Troglitazone Thumb 28.9%
8 Approved;
Nutraceutical
SmallMoleculeDrug DB00117 Histidine Thumb 27.7%
9 Approved BiotechDrug DB06404 Human C1-esterase inhibitor Thumb 27.0%
10 Approved;
Investigational;
Withdrawn
BiotechDrug DB00055 Drotrecogin alfa Thumb 26.5%
11 Approved;
Nutraceutical
SmallMoleculeDrug DB00128 L-Aspartic Acid Thumb 26.4%
12 Approved;
Investigational
BiotechDrug DB05099 Ancrod Thumb 24.3%
13 Approved;
Nutraceutical
SmallMoleculeDrug DB00126 Vitamin C Thumb 23.7%
14 Approved SmallMoleculeDrug DB00675 Tamoxifen Thumb 23.6%
15 Investigational SmallMoleculeDrug DB05476 WX-UK1 Thumb 23.6%
16 Approved;
Nutraceutical
SmallMoleculeDrug DB00142 Glutamic Acid Thumb 23.5%
17 Approved;
Experimental
SmallMoleculeDrug DB03017 Lauric Acid Thumb 22.9%
18 Experimental SmallMoleculeDrug DB02459 4-Guanidinobenzoic Acid Thumb 22.3%
19 Approved BiotechDrug DB08888 Ocriplasmin Thumb 22.2%
20 Approved;
Investigational;
Nutraceutical
SmallMoleculeDrug DB00167 L-Isoleucine Thumb 22.2%



  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.