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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P10253
No. Gene UniProt ID Protein Name Pathway PDB
1 GAA P10253 Lysosomal alpha-glucosidase hsa00052; hsa00500; hsa01100; hsa04142 NA

3 known interactions (drugs) of input target (GAA): Lysosomal alpha-glucosidase
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Investigational SmallMoleculeDrug DB05200 AT2220 Thumb
2 Approved SmallMoleculeDrug DB00491 Miglitol Thumb
3 Approved;
SmallMoleculeDrug DB00284 Acarbose Thumb

20 predicted interactions (drugs) of input target (GAA): Lysosomal alpha-glucosidase
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
SmallMoleculeDrug DB04878 Voglibose Thumb 22.5%
2 Approved;
SmallMoleculeDrug DB01593 Zinc Thumb 21.6%
3 Approved;
Vet approved
SmallMoleculeDrug DB01110 Miconazole Thumb 20.7%
4 Approved;
Vet approved
SmallMoleculeDrug DB00162 Vitamin A Thumb 18.6%
5 Approved;
BiotechDrug DB00005 Etanercept Thumb 17.5%
6 Approved;
BiotechDrug DB00056 Gemtuzumab ozogamicin Thumb 16.4%
7 Approved SmallMoleculeDrug DB00457 Prazosin Thumb 16.3%
8 Approved;
Vet approved
SmallMoleculeDrug DB01159 Halothane Thumb 16.3%
9 Approved;
SmallMoleculeDrug DB01708 Prasterone Thumb 16.1%
10 Approved;
BiotechDrug DB00095 Efalizumab Thumb 15.9%
11 Approved BiotechDrug DB00054 Abciximab Thumb 15.4%
12 Approved SmallMoleculeDrug DB00493 Cefotaxime Thumb 15.4%
13 Experimental SmallMoleculeDrug DB04315 Guanosine-5'-Diphosphate Thumb 15.3%
14 Investigational;
BiotechDrug DB00111 Daclizumab Thumb 15.0%
15 Experimental SmallMoleculeDrug DB04400 L-erythro-7,8-dihydrobiopterin Thumb 14.4%
16 Investigational SmallMoleculeDrug DB12548 Sparsentan Thumb 14.2%
17 Approved;
BiotechDrug DB00075 Muromonab Thumb 14.1%
18 Experimental SmallMoleculeDrug DB04327 Phosphatidylethanolamine Thumb 14.0%
19 Approved BiotechDrug DB00002 Cetuximab Thumb 13.9%
20 Approved;
BiotechDrug DB00074 Basiliximab Thumb 13.7%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.