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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P38435
No. Gene UniProt ID Protein Name Pathway PDB
1 GGCX P38435 Vitamin K-dependent gamma-carboxylase hsa00130 NA


9 known interactions (drugs) of input target (GGCX): Vitamin K-dependent gamma-carboxylase
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational		 SmallMoleculeDrug DB01022 Phylloquinone Thumb
2 Approved SmallMoleculeDrug DB01125 Anisindione Thumb
3 Approved;
Nutraceutical		 SmallMoleculeDrug DB00170 Menadione Thumb
4 Approved;
Investigational;
Withdrawn		 BiotechDrug DB00055 Drotrecogin alfa Thumb
5 Approved BiotechDrug DB13152 Coagulation Factor IX Human Thumb
6 Approved;
Investigational		 BiotechDrug DB00100 Coagulation Factor IX (Recombinant) Thumb
7 Approved SmallMoleculeDrug DB09332 Kappadione Thumb
8 Approved;
Nutraceutical		 SmallMoleculeDrug DB00142 Glutamic Acid Thumb
9 Approved BiotechDrug DB00036 Coagulation factor VIIa Recombinant Human Thumb


20 predicted interactions (drugs) of input target (GGCX): Vitamin K-dependent gamma-carboxylase
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 BiotechDrug DB13151 Anti-inhibitor coagulant complex Thumb 44.8%
2 Approved;
Investigational		 BiotechDrug DB13933 Nonacog beta pegol Thumb 43.8%
3 Experimental SmallMoleculeDrug DB03847 Gamma-Carboxy-Glutamic Acid Thumb 41.1%
4 Approved;
Investigational		 SmallMoleculeDrug DB00464 Sodium Tetradecyl Sulfate Thumb 37.1%
5 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00143 Glutathione Thumb 36.1%
6 Approved;
Investigational		 SmallMoleculeDrug DB01593 Zinc Thumb 34.2%
7 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00114 Pyridoxal Phosphate Thumb 32.1%
8 Experimental SmallMoleculeDrug DB07376 5-(DIMETHYLAMINO)-1-NAPHTHALENESULFONIC ACID(DANSYL ACID) Thumb 30.8%
9 Experimental SmallMoleculeDrug DB04590 (2R)-({4-[AMINO(IMINO)METHYL]PHENYL}AMINO){5-ETHOXY-2-FLUORO-3-[(3R)-TETRAHYDROFURAN-3-YLOXY]PHENYL}ACETICACID Thumb 30.3%
10 Approved;
Investigational		 BiotechDrug DB09109 Turoctocog alfa Thumb 29.7%
11 Approved BiotechDrug DB13149 Protein S human Thumb 28.6%
12 Experimental SmallMoleculeDrug DB04767 N-[1-(4-CARBAMIMIDOYL-BENZYLCARBAMOYL)-3-METHYLSULFANYL-PROPYL]-3-HYDROXY-2-PROPOXYAMINO-BUTYRAMID Thumb 27.8%
13 Experimental SmallMoleculeDrug DB08232 [5-(5-Amino-1H-pyrrolo[3,2-b]pyridin-2-yl)-6-hydroxy-3'-nitro-3-biphenylyl]acetic acid Thumb 27.6%
14 Approved;
Investigational		 SmallMoleculeDrug DB05260 Gallium nitrate Thumb 27.6%
15 Investigational BiotechDrug DB06245 Lanoteplase Thumb 26.1%
16 Experimental SmallMoleculeDrug DB04758 2-[2-ETHANESULFONYLAMINO-3-(1H-INDOL-3-YL)-PROPIONYLAMINO]-PENTANEDIOIC ACID 5-AMIDE 1-(4-CARBAMIM IDOYL-BENZYLAMIDE) Thumb 25.6%
17 Approved;
Investigational		 BiotechDrug DB13150 Coagulation factor VII human Thumb 25.0%
18 Approved BiotechDrug DB00031 Tenecteplase Thumb 24.7%
19 Experimental SmallMoleculeDrug DB07277 2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}ETHANESULFONAMIDE Thumb 24.4%
20 Experimental SmallMoleculeDrug DB04606 2-[2-ETHANESULFONYLAMINO-3-(5-PROPOXY-1H-INDOL-3-YL)-PROPIONYLAMINO]-PENTANEDIOIC ACID 5-AMIDE 1-(4-CARBAMIMIDOYL-BENZYLAMIDE) Thumb 24.4%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.