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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P32418
No. Gene UniProt ID Protein Name Pathway PDB
1 SLC8A1 P32418 Sodium/calcium exchanger 1 hsa04020; hsa04022; hsa04260; hsa04261; hsa04371; hsa04740; hsa04961; hsa04974; hsa04978; hsa05410; hsa05412; hsa05414 NA


3 known interactions (drugs) of input target (SLC8A1): Sodium/calcium exchanger 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Nutraceutical		 SmallMoleculeDrug DB00132 Alpha-Linolenic Acid Thumb
2 Approved;
Nutraceutical		 SmallMoleculeDrug DB00159 Icosapent Thumb
3 Investigational SmallMoleculeDrug DB06231 Caldaret Thumb


20 predicted interactions (drugs) of input target (SLC8A1): Sodium/calcium exchanger 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Experimental SmallMoleculeDrug DB02746 Phthalic Acid Thumb 26.5%
2 Experimental SmallMoleculeDrug DB02379 Beta-D-Glucose Thumb 22.3%
3 Approved;
Investigational		 SmallMoleculeDrug DB00412 Rosiglitazone Thumb 21.4%
4 Approved;
Experimental;
Investigational		 SmallMoleculeDrug DB02709 Resveratrol Thumb 20.8%
5 Approved;
Nutraceutical		 SmallMoleculeDrug DB13961 Fish oil Thumb 20.0%
6 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB04224 Oleic Acid Thumb 19.6%
7 Investigational;
Withdrawn		 SmallMoleculeDrug DB00197 Troglitazone Thumb 19.2%
8 Investigational SmallMoleculeDrug DB05187 Elafibranor Thumb 18.8%
9 Approved SmallMoleculeDrug DB00421 Spironolactone Thumb 18.2%
10 Experimental SmallMoleculeDrug DB04557 Arachidonic Acid Thumb 18.2%
11 Experimental SmallMoleculeDrug DB02266 Flufenamic Acid Thumb 17.6%
12 Approved;
Nutraceutical		 SmallMoleculeDrug DB00168 Aspartame Thumb 16.7%
13 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00936 Salicylic acid Thumb 16.6%
14 Experimental SmallMoleculeDrug DB08402 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID Thumb 16.6%
15 Investigational SmallMoleculeDrug DB06521 Ertiprotafib Thumb 16.6%
16 Approved SmallMoleculeDrug DB00675 Tamoxifen Thumb 16.1%
17 Investigational SmallMoleculeDrug DB05188 KD3010 Thumb 16.0%
18 Experimental SmallMoleculeDrug DB03951 N-acetyl-D-glucosamine-6-phosphate Thumb 15.8%
19 Experimental SmallMoleculeDrug DB07724 Indeglitazar Thumb 15.8%
20 Experimental SmallMoleculeDrug DB08078 {4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy}acetic acid Thumb 15.8%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.