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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q08499
No. Gene UniProt ID Protein Name Pathway PDB
1 PDE4D Q08499 cAMP-specific 3',5'-cyclic phosphodiesterase 4D hsa00230; hsa04024; hsa04928; hsa05032

26 known interactions (drugs) of input target (PDE4D): cAMP-specific 3',5'-cyclic phosphodiesterase 4D
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Experimental SmallMoleculeDrug DB04469 1-(4-Methoxyphenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester Thumb
2 Experimental SmallMoleculeDrug DB01791 Piclamilast Thumb
3 Approved;
SmallMoleculeDrug DB01088 Iloprost Thumb
4 Approved;
SmallMoleculeDrug DB05219 Crisaborole Thumb
5 Experimental SmallMoleculeDrug DB08299 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid Thumb
6 Investigational SmallMoleculeDrug DB05298 Tetomilast Thumb
7 Experimental SmallMoleculeDrug DB01959 3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester Thumb
8 Investigational SmallMoleculeDrug DB06246 Exisulind Thumb
9 Experimental SmallMoleculeDrug DB04149 (R)-Rolipram Thumb
10 Investigational SmallMoleculeDrug DB03849 Cilomilast Thumb
11 Approved;
SmallMoleculeDrug DB05266 Ibudilast Thumb
12 Experimental SmallMoleculeDrug DB03606 (S)-Rolipram Thumb
13 Experimental SmallMoleculeDrug DB04271 3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester Thumb
14 Experimental SmallMoleculeDrug DB07051 3,5-DIMETHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER Thumb
15 Experimental SmallMoleculeDrug DB07954 3-isobutyl-1-methyl-7H-xanthine Thumb
16 Experimental SmallMoleculeDrug DB02918 6-(4-Difluoromethoxy-3-Methoxy-Phenyl)-2h-Pyridazin-3-One Thumb
17 Approved SmallMoleculeDrug DB00201 Caffeine Thumb
18 Experimental SmallMoleculeDrug DB06842 (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one Thumb
19 Investigational SmallMoleculeDrug DB01954 Rolipram Thumb
20 Approved SmallMoleculeDrug DB00651 Dyphylline Thumb
21 Approved;
SmallMoleculeDrug DB00131 Adenosine monophosphate Thumb
22 Approved;
SmallMoleculeDrug DB05676 Apremilast Thumb
23 Approved SmallMoleculeDrug DB01656 Roflumilast Thumb
24 Experimental SmallMoleculeDrug DB03183 1-(4-Aminophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester Thumb
25 Experimental SmallMoleculeDrug DB02676 2-[3-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Propylamino]-2-Hydroxymethyl-Propane-1,3-Diol Thumb
26 Approved SmallMoleculeDrug DB09283 Trapidil Thumb

20 predicted interactions (drugs) of input target (PDE4D): cAMP-specific 3',5'-cyclic phosphodiesterase 4D
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
SmallMoleculeDrug DB00806 Pentoxifylline Thumb 59.2%
2 Approved SmallMoleculeDrug DB00277 Theophylline Thumb 53.7%
3 Experimental SmallMoleculeDrug DB01647 Daxalipram Thumb 47.9%
4 Approved;
SmallMoleculeDrug DB00824 Enprofylline Thumb 47.7%
5 Approved SmallMoleculeDrug DB08811 Tofisopam Thumb 46.7%
6 Approved SmallMoleculeDrug DB01427 Amrinone Thumb 46.1%
7 Approved;
SmallMoleculeDrug DB01113 Papaverine Thumb 43.2%
8 Experimental SmallMoleculeDrug DB03807 1-(2-Chlorophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester Thumb 43.2%
9 Experimental SmallMoleculeDrug DB02660 Filaminast Thumb 42.7%
10 Investigational SmallMoleculeDrug DB06479 Propentofylline Thumb 42.6%
11 Approved;
SmallMoleculeDrug DB09130 Copper Thumb 42.6%
12 Approved;
SmallMoleculeDrug DB01412 Theobromine Thumb 41.4%
13 Approved SmallMoleculeDrug DB00975 Dipyridamole Thumb 41.0%
14 Investigational SmallMoleculeDrug DB05876 PDE4 Thumb 40.6%
15 Experimental SmallMoleculeDrug DB02315 Cyclic Guanosine Monophosphate Thumb 39.5%
16 Experimental SmallMoleculeDrug DB06909 1-ethyl-N-(phenylmethyl)-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide Thumb 38.1%
17 Experimental SmallMoleculeDrug DB03349 8-Bromo-Adenosine-5'-Monophosphate Thumb 35.8%
18 Experimental;
SmallMoleculeDrug DB03496 Alvocidib Thumb 35.1%
19 Experimental;
SmallMoleculeDrug DB03366 Imidazole Thumb 35.0%
20 Approved;
SmallMoleculeDrug DB06751 Drotaverine Thumb 33.2%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.