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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q9Y5Y9
No. Gene UniProt ID Protein Name Pathway PDB
1 SCN10A Q9Y5Y9 Sodium channel protein type 10 subunit alpha NA NA


19 known interactions (drugs) of input target (SCN10A): Sodium channel protein type 10 subunit alpha
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational		 SmallMoleculeDrug DB01086 Benzocaine Thumb
2 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00721 Procaine Thumb
3 Approved SmallMoleculeDrug DB01161 Chloroprocaine Thumb
4 Approved SmallMoleculeDrug DB13269 Dichlorobenzyl alcohol Thumb
5 Approved;
Withdrawn		 SmallMoleculeDrug DB00473 Hexylcaine Thumb
6 Approved SmallMoleculeDrug DB00296 Ropivacaine Thumb
7 Approved SmallMoleculeDrug DB01173 Orphenadrine Thumb
8 Approved;
Vet approved		 SmallMoleculeDrug DB00961 Mepivacaine Thumb
9 Approved;
Investigational		 SmallMoleculeDrug DB00313 Valproic Acid Thumb
10 Approved SmallMoleculeDrug DB00645 Dyclonine Thumb
11 Approved SmallMoleculeDrug DB06218 Lacosamide Thumb
12 Approved;
Investigational		 SmallMoleculeDrug DB00297 Bupivacaine Thumb
13 Approved;
Investigational		 SmallMoleculeDrug DB00892 Oxybuprocaine Thumb
14 Approved;
Investigational		 SmallMoleculeDrug DB01002 Levobupivacaine Thumb
15 Approved;
Illicit		 SmallMoleculeDrug DB00907 Cocaine Thumb
16 Approved;
Vet approved		 SmallMoleculeDrug DB00807 Proparacaine Thumb
17 Approved;
Vet approved		 SmallMoleculeDrug DB00281 Lidocaine Thumb
18 Approved;
Vet approved		 SmallMoleculeDrug DB00527 Cinchocaine Thumb
19 Approved;
Investigational		 SmallMoleculeDrug DB05541 Brivaracetam Thumb


20 predicted interactions (drugs) of input target (SCN10A): Sodium channel protein type 10 subunit alpha
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Vet approved		 SmallMoleculeDrug DB00252 Phenytoin Thumb 53.4%
2 Investigational SmallMoleculeDrug DB05232 Tetrodotoxin Thumb 48.7%
3 Approved;
Investigational		 SmallMoleculeDrug DB00909 Zonisamide Thumb 47.8%
4 Approved;
Investigational		 SmallMoleculeDrug DB00243 Ranolazine Thumb 43.0%
5 Approved SmallMoleculeDrug DB00514 Dextromethorphan Thumb 40.7%
6 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb 40.0%
7 Approved;
Vet approved		 SmallMoleculeDrug DB01221 Ketamine Thumb 39.5%
8 Approved SmallMoleculeDrug DB00333 Methadone Thumb 37.9%
9 Approved;
Investigational		 SmallMoleculeDrug DB00622 Nicardipine Thumb 37.5%
10 Approved SmallMoleculeDrug DB00805 Minaprine Thumb 32.3%
11 Approved SmallMoleculeDrug DB04855 Dronedarone Thumb 31.6%
12 Approved SmallMoleculeDrug DB00280 Disopyramide Thumb 30.7%
13 Experimental SmallMoleculeDrug DB04464 N-Formylmethionine Thumb 29.8%
14 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01110 Miconazole Thumb 29.6%
15 Approved SmallMoleculeDrug DB06201 Rufinamide Thumb 29.6%
16 Approved;
Investigational		 SmallMoleculeDrug DB00568 Cinnarizine Thumb 28.6%
17 Approved;
Investigational		 SmallMoleculeDrug DB06148 Mianserin Thumb 28.6%
18 Approved SmallMoleculeDrug DB00202 Succinylcholine Thumb 28.3%
19 Approved;
Withdrawn		 SmallMoleculeDrug DB01195 Flecainide Thumb 28.1%
20 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb 27.4%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.