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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q9UKM7
No. Gene UniProt ID Protein Name Pathway PDB
1 MAN1B1 Q9UKM7 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase hsa00510; hsa01100; hsa04141 1FMI; 1FO2; 1FO3; 1X9D

4 known interactions (drugs) of input target (MAN1B1): Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Experimental SmallMoleculeDrug DB03206 Duvoglustat Thumb
2 Experimental SmallMoleculeDrug DB02422 Methyl-2-S-(Alpha-D-Mannopyranosyl)-2-Thio-Alpha-D-Mannopyranoside Thumb
3 Experimental SmallMoleculeDrug DB01955 1,4-Butanediol Thumb
4 Experimental SmallMoleculeDrug DB02742 Kifunensine Thumb

20 predicted interactions (drugs) of input target (MAN1B1): Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
SmallMoleculeDrug DB00142 Glutamic Acid Thumb 46.2%
2 Approved;
SmallMoleculeDrug DB03017 Lauric Acid Thumb 20.0%
3 Approved;
SmallMoleculeDrug DB00786 Marimastat Thumb 19.9%
4 Experimental SmallMoleculeDrug DB01812 Adenosine-3'-5'-Diphosphate Thumb 19.8%
5 Investigational SmallMoleculeDrug DB05737 Varespladib methyl Thumb 18.6%
6 Experimental SmallMoleculeDrug DB01854 5-Bromonicotinamide Thumb 18.3%
7 Approved;
SmallMoleculeDrug DB11638 Artenimol Thumb 18.1%
8 Approved;
SmallMoleculeDrug DB00128 L-Aspartic Acid Thumb 18.0%
9 Approved;
SmallMoleculeDrug DB01577 Methamphetamine Thumb 17.6%
10 Experimental SmallMoleculeDrug DB01946 3-[1-(3-Aminopropyl)-1h-Indol-3-Yl]-4-(1-Methyl-1h-Indol-3-Yl)-1h-Pyrrole-2,5-Dione Thumb 17.4%
11 Approved;
SmallMoleculeDrug DB00114 Pyridoxal Phosphate Thumb 16.6%
12 Experimental SmallMoleculeDrug DB08447 3-{3-[(DIMETHYLAMINO)METHYL]-1H-INDOL-7-YL}PROPAN-1-OL Thumb 16.5%
13 Approved SmallMoleculeDrug DB03754 Tromethamine Thumb 16.1%
14 Experimental SmallMoleculeDrug DB02322 Heparin Disaccharide I-S Thumb 15.5%
15 Experimental SmallMoleculeDrug DB03784 Elaidoylamide Thumb 15.2%
16 Approved;
Vet approved
SmallMoleculeDrug DB00586 Diclofenac Thumb 15.1%
17 Experimental SmallMoleculeDrug DB02726 2-Phosphoglycolic Acid Thumb 15.0%
18 Approved;
SmallMoleculeDrug DB04894 Vapreotide Thumb 14.9%
19 Experimental SmallMoleculeDrug DB04318 Nα-[(2S)-2-{[(S)-[(1S)-1-{[(Benzyloxy)carbonyl]amino}-2-phenylethyl](hydroxy)phosphoryl]methyl}-5-phenylpentanoyl]-L-tryptophanamide Thumb 14.9%
20 Experimental SmallMoleculeDrug DB08430 PARA-NITROPHENYL 1-THIO-BETA-D-GLUCOPYRANOSIDE Thumb 14.8%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.