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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P53355
No. Gene UniProt ID Protein Name Pathway PDB
1 DAPK1 P53355 Death-associated protein kinase 1 hsa04140; hsa05200; hsa05219


4 known interactions (drugs) of input target (DAPK1): Death-associated protein kinase 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational		 SmallMoleculeDrug DB12010 Fostamatinib Thumb
2 Experimental SmallMoleculeDrug DB04069 5,6-Dihydro-Benzo[H]Cinnolin-3-Ylamine Thumb
3 Experimental SmallMoleculeDrug DB04395 Phosphoaminophosphonic Acid-Adenylate Ester Thumb
4 Experimental SmallMoleculeDrug DB07444 6-(3-AMINOPROPYL)-4,9-DIMETHYLPYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE Thumb


20 predicted interactions (drugs) of input target (DAPK1): Death-associated protein kinase 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Experimental SmallMoleculeDrug DB02010 Staurosporine Thumb 32.9%
2 Approved;
Investigational		 SmallMoleculeDrug DB01254 Dasatinib Thumb 32.1%
3 Approved SmallMoleculeDrug DB08896 Regorafenib Thumb 29.2%
4 Approved SmallMoleculeDrug DB00619 Imatinib Thumb 24.5%
5 Investigational SmallMoleculeDrug DB12742 Amuvatinib Thumb 23.7%
6 Experimental SmallMoleculeDrug DB04315 Guanosine-5'-Diphosphate Thumb 21.8%
7 Approved;
Investigational		 SmallMoleculeDrug DB09130 Copper Thumb 21.8%
8 Experimental SmallMoleculeDrug DB07664 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE Thumb 21.4%
9 Approved SmallMoleculeDrug DB09079 Nintedanib Thumb 20.3%
10 Approved;
Investigational		 SmallMoleculeDrug DB08901 Ponatinib Thumb 20.0%
11 Approved;
Nutraceutical		 SmallMoleculeDrug DB00173 Adenine Thumb 19.2%
12 Approved SmallMoleculeDrug DB06589 Pazopanib Thumb 18.6%
13 Approved;
Nutraceutical		 SmallMoleculeDrug DB00138 Cystine Thumb 18.3%
14 Approved;
Investigational		 SmallMoleculeDrug DB06595 Midostaurin Thumb 18.2%
15 Experimental SmallMoleculeDrug DB03814 2-(N-Morpholino)-Ethanesulfonic Acid Thumb 17.9%
16 Investigational SmallMoleculeDrug DB05184 XL228 Thumb 17.4%
17 Approved;
Withdrawn		 SmallMoleculeDrug DB01244 Bepridil Thumb 17.2%
18 Experimental SmallMoleculeDrug DB04464 N-Formylmethionine Thumb 16.9%
19 Approved;
Investigational		 SmallMoleculeDrug DB12267 Brigatinib Thumb 16.7%
20 Approved SmallMoleculeDrug DB00308 Ibutilide Thumb 16.4%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.