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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P08842
No. Gene UniProt ID Protein Name Pathway PDB
1 STS P08842 Steryl-sulfatase hsa00140 1P49


2 known interactions (drugs) of input target (STS): Steryl-sulfatase
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Investigational SmallMoleculeDrug DB02292 Irosustat Thumb
2 Experimental SmallMoleculeDrug DB02735 2-Amino-3-Oxo-4-Sulfo-Butyric Acid Thumb


20 predicted interactions (drugs) of input target (STS): Steryl-sulfatase
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Nutraceutical SmallMoleculeDrug DB00116 Tetrahydrofolic acid Thumb 20.9%
2 Approved;
Investigational		 SmallMoleculeDrug DB01064 Isoprenaline Thumb 16.5%
3 Approved;
Vet approved		 SmallMoleculeDrug DB00999 Hydrochlorothiazide Thumb 16.1%
4 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB00690 Flurazepam Thumb 15.6%
5 Approved;
Vet approved		 SmallMoleculeDrug DB01021 Trichlormethiazide Thumb 15.5%
6 Investigational SmallMoleculeDrug DB05147 CYT997 Thumb 14.5%
7 Investigational SmallMoleculeDrug DB05022 Amonafide Thumb 14.5%
8 Experimental SmallMoleculeDrug DB04233 (Hydroxyethyloxy)Tri(Ethyloxy)Octane Thumb 14.3%
9 Investigational SmallMoleculeDrug DB06042 ZEN-012 Thumb 14.3%
10 Approved SmallMoleculeDrug DB01325 Quinethazone Thumb 13.6%
11 Approved;
Investigational		 SmallMoleculeDrug DB12278 Propiverine Thumb 13.5%
12 Approved;
Vet approved		 SmallMoleculeDrug DB00880 Chlorothiazide Thumb 13.2%
13 Investigational SmallMoleculeDrug DB05223 Pracinostat Thumb 12.6%
14 Approved SmallMoleculeDrug DB01092 Ouabain Thumb 12.6%
15 Experimental SmallMoleculeDrug DB08130 N-(5-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}-1,3,4-oxadiazol-2-yl)ethane-1,2-diamine Thumb 12.6%
16 Experimental SmallMoleculeDrug DB02506 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid Thumb 12.3%
17 Experimental SmallMoleculeDrug DB07514 3-(2-aminoquinazolin-6-yl)-1-(3,3-dimethylindolin-6-yl)-4-methylpyridin-2(1H)-one Thumb 12.2%
18 Approved SmallMoleculeDrug DB00067 Vasopressin Thumb 12.2%
19 Experimental SmallMoleculeDrug DB02726 2-Phosphoglycolic Acid Thumb 12.2%
20 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00119 Pyruvic acid Thumb 12.1%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.