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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q13131
No. Gene UniProt ID Protein Name Pathway PDB
1 PRKAA1 Q13131 5'-AMP-activated protein kinase catalytic subunit alpha-1 hsa04068; hsa04140; hsa04150; hsa04151; hsa04152; hsa04211; hsa04213; hsa04371; hsa04530; hsa04710; hsa04714; hsa04910; hsa04920; hsa04921; hsa04922; hsa04931; hsa04932; hsa05410; hsa05418 4RED; 4RER; 4REW

5 known interactions (drugs) of input target (PRKAA1): 5'-AMP-activated protein kinase catalytic subunit alpha-1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Approved;
SmallMoleculeDrug DB00914 Phenformin Thumb
2 Approved;
SmallMoleculeDrug DB12010 Fostamatinib Thumb
3 Approved;
SmallMoleculeDrug DB00131 Adenosine monophosphate Thumb
4 Approved;
Vet approved
SmallMoleculeDrug DB00945 Acetylsalicylic acid Thumb
5 Investigational;
SmallMoleculeDrug DB00171 ATP Thumb

20 predicted interactions (drugs) of input target (PRKAA1): 5'-AMP-activated protein kinase catalytic subunit alpha-1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved SmallMoleculeDrug DB01016 Glyburide Thumb 32.9%
2 Approved;
SmallMoleculeDrug DB00157 NADH Thumb 31.6%
3 Investigational SmallMoleculeDrug DB06486 Enzastaurin Thumb 29.1%
4 Approved SmallMoleculeDrug DB08896 Regorafenib Thumb 28.3%
5 Approved;
SmallMoleculeDrug DB01254 Dasatinib Thumb 24.5%
6 Approved SmallMoleculeDrug DB00675 Tamoxifen Thumb 22.0%
7 Approved;
Vet approved
SmallMoleculeDrug DB01392 Yohimbine Thumb 20.1%
8 Investigational SmallMoleculeDrug DB06521 Ertiprotafib Thumb 19.7%
9 Approved;
SmallMoleculeDrug DB01169 Arsenic trioxide Thumb 19.0%
10 Approved SmallMoleculeDrug DB00331 Metformin Thumb 18.9%
11 Approved SmallMoleculeDrug DB00277 Theophylline Thumb 18.8%
12 Approved;
Vet approved
SmallMoleculeDrug DB01183 Naloxone Thumb 18.7%
13 Approved;
SmallMoleculeDrug DB02772 Sucrose Thumb 18.6%
14 Investigational SmallMoleculeDrug DB06408 Taribavirin Thumb 18.6%
15 Approved;
Vet approved
SmallMoleculeDrug DB00145 Glycine Thumb 18.1%
16 Approved;
SmallMoleculeDrug DB08901 Ponatinib Thumb 17.7%
17 Experimental SmallMoleculeDrug DB06905 (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid Thumb 17.6%
18 Approved;
SmallMoleculeDrug DB09121 Aurothioglucose Thumb 17.5%
19 Approved BiotechDrug DB00039 Palifermin Thumb 17.2%
20 Experimental SmallMoleculeDrug DB02506 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid Thumb 16.7%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.