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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P14174
No. Gene UniProt ID Protein Name Pathway PDB
1 MIF P14174 Macrophage migration inhibitory factor hsa00350; hsa00360


9 known interactions (drugs) of input target (MIF): Macrophage migration inhibitory factor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Nutraceutical;
Vet approved		 SmallMoleculeDrug DB04272 Citric Acid Thumb
2 Experimental SmallMoleculeDrug DB08335 4-HYDROXYBENZALDEHYDE O-(3,3-DIMETHYLBUTANOYL)OXIME Thumb
3 Experimental SmallMoleculeDrug DB08334 3-FLUORO-4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME Thumb
4 Experimental SmallMoleculeDrug DB02728 7-Hydroxy-2-Oxo-Chromene-3-Carboxylic Acid Ethyl Ester Thumb
5 Experimental SmallMoleculeDrug DB08765 6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE Thumb
6 Experimental SmallMoleculeDrug DB08333 4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME Thumb
7 Experimental SmallMoleculeDrug DB07718 3-(4-HYDROXY-PHENYL)PYRUVIC ACID Thumb
8 Experimental;
Investigational		 SmallMoleculeDrug DB01880 3,4-Dihydroxycinnamic Acid Thumb
9 Experimental SmallMoleculeDrug DB07888 3-(4-HYDROXYPHENYL)-4,5-DIHYDRO-5-ISOXAZOLE-ACETIC ACID METHYL ESTER Thumb


20 predicted interactions (drugs) of input target (MIF): Macrophage migration inhibitory factor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 SmallMoleculeDrug DB00523 Alitretinoin Thumb 31.2%
2 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00114 Pyridoxal Phosphate Thumb 29.2%
3 Experimental SmallMoleculeDrug DB06921 (2S)-2-[3-(AMINOMETHYL)PHENYL]-3-[(R)-HYDROXY{(1R)-2-METHYL-1-[(PHENYLSULFONYL)AMINO]PROPYL}PHOSPHORYL]PROPANOIC ACID Thumb 24.9%
4 Withdrawn SmallMoleculeDrug DB00926 Etretinate Thumb 23.7%
5 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00143 Glutathione Thumb 22.6%
6 Approved BiotechDrug DB00032 Menotropins Thumb 22.3%
7 Approved;
Investigational		 BiotechDrug DB00030 Insulin Human Thumb 22.2%
8 Experimental SmallMoleculeDrug DB08358 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE Thumb 21.3%
9 Approved;
Investigational		 SmallMoleculeDrug DB12010 Fostamatinib Thumb 20.8%
10 Investigational;
Nutraceutical		 SmallMoleculeDrug DB01992 Coenzyme A Thumb 20.7%
11 Approved SmallMoleculeDrug DB00459 Acitretin Thumb 20.3%
12 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00755 Tretinoin Thumb 19.6%
13 Investigational SmallMoleculeDrug DB05281 S-8184 Thumb 19.5%
14 Approved;
Investigational		 BiotechDrug DB06043 Olaratumab Thumb 19.1%
15 Approved SmallMoleculeDrug DB00210 Adapalene Thumb 19.0%
16 Investigational SmallMoleculeDrug DB05785 LGD-1550 Thumb 18.9%
17 Approved;
Investigational		 SmallMoleculeDrug DB01193 Acebutolol Thumb 18.7%
18 Investigational SmallMoleculeDrug DB05465 Tandutinib Thumb 18.5%
19 Approved SmallMoleculeDrug DB00693 Fluorescein Thumb 17.7%
20 Approved;
Nutraceutical		 SmallMoleculeDrug DB00151 L-Cysteine Thumb 17.6%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.