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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P19652
No. Gene UniProt ID Protein Name Pathway PDB
1 ORM2 P19652 Alpha-1-acid glycoprotein 2 NA 3APU; 3APV; 3APW; 3APX


8 known interactions (drugs) of input target (ORM2): Alpha-1-acid glycoprotein 2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB00497 Oxycodone Thumb
2 Approved SmallMoleculeDrug DB00458 Imipramine Thumb
3 Approved;
Vet approved		 SmallMoleculeDrug DB00281 Lidocaine Thumb
4 Approved;
Investigational		 SmallMoleculeDrug DB01593 Zinc Thumb
5 Approved SmallMoleculeDrug DB00333 Methadone Thumb
6 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00477 Chlorpromazine Thumb
7 Approved SmallMoleculeDrug DB00280 Disopyramide Thumb
8 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB01041 Thalidomide Thumb


20 predicted interactions (drugs) of input target (ORM2): Alpha-1-acid glycoprotein 2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb 54.8%
2 Approved;
Investigational		 SmallMoleculeDrug DB09130 Copper Thumb 50.5%
3 Approved;
Investigational		 SmallMoleculeDrug DB01238 Aripiprazole Thumb 49.4%
4 Approved;
Investigational		 SmallMoleculeDrug DB01142 Doxepin Thumb 49.1%
5 Approved;
Investigational		 SmallMoleculeDrug DB00334 Olanzapine Thumb 48.2%
6 Approved SmallMoleculeDrug DB00370 Mirtazapine Thumb 47.8%
7 Approved SmallMoleculeDrug DB00408 Loxapine Thumb 47.6%
8 Approved;
Vet approved		 SmallMoleculeDrug DB01221 Ketamine Thumb 46.9%
9 Approved SmallMoleculeDrug DB00988 Dopamine Thumb 44.8%
10 Approved;
Investigational		 SmallMoleculeDrug DB00934 Maprotiline Thumb 44.8%
11 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb 44.3%
12 Approved;
Investigational		 SmallMoleculeDrug DB00555 Lamotrigine Thumb 44.3%
13 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb 43.8%
14 Approved SmallMoleculeDrug DB06216 Asenapine Thumb 43.5%
15 Approved;
Investigational		 SmallMoleculeDrug DB00734 Risperidone Thumb 43.3%
16 Approved;
Investigational		 SmallMoleculeDrug DB06148 Mianserin Thumb 43.2%
17 Approved SmallMoleculeDrug DB00777 Propiomazine Thumb 42.9%
18 Approved;
Investigational		 SmallMoleculeDrug DB01151 Desipramine Thumb 42.2%
19 Approved;
Investigational		 SmallMoleculeDrug DB14185 Aripiprazole lauroxil Thumb 42.1%
20 Approved SmallMoleculeDrug DB00246 Ziprasidone Thumb 42.1%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.