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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P29597
No. Gene UniProt ID Protein Name Pathway PDB
1 TYK2 P29597 Non-receptor tyrosine-protein kinase TYK2 hsa04217; hsa04380; hsa04621; hsa04630; hsa04658; hsa04659; hsa05145; hsa05160; hsa05162; hsa05164; hsa05165; hsa05167; hsa05168; hsa05169 3LXN; 3LXP; 3NYX; 3NZ0; 3ZON; 4GFO; 4GIH; 4GII; 4GJ2; 4GJ3; 4GVJ; 4OLI; 4PO6; 4PY1; 4WOV; 5C01; 5C03

3 known interactions (drugs) of input target (TYK2): Non-receptor tyrosine-protein kinase TYK2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Experimental SmallMoleculeDrug DB04716 2-(1,1-DIMETHYLETHYL)9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLIN-7-ONE Thumb
2 Approved;
SmallMoleculeDrug DB12010 Fostamatinib Thumb
3 Approved;
SmallMoleculeDrug DB08895 Tofacitinib Thumb

20 predicted interactions (drugs) of input target (TYK2): Non-receptor tyrosine-protein kinase TYK2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
SmallMoleculeDrug DB11817 Baricitinib Thumb 43.1%
2 Approved SmallMoleculeDrug DB08877 Ruxolitinib Thumb 32.2%
3 Experimental SmallMoleculeDrug DB02375 Myricetin Thumb 25.6%
4 Approved;
SmallMoleculeDrug DB01254 Dasatinib Thumb 24.5%
5 Experimental SmallMoleculeDrug DB04395 Phosphoaminophosphonic Acid-Adenylate Ester Thumb 23.2%
6 Approved SmallMoleculeDrug DB08896 Regorafenib Thumb 22.4%
7 Approved SmallMoleculeDrug DB00233 Aminosalicylic Acid Thumb 21.9%
8 Approved;
SmallMoleculeDrug DB12267 Brigatinib Thumb 20.6%
9 Experimental SmallMoleculeDrug DB07162 4-(3-amino-1H-indazol-5-yl)-N-tert-butylbenzenesulfonamide Thumb 20.5%
10 Experimental SmallMoleculeDrug DB02010 Staurosporine Thumb 19.2%
11 Experimental SmallMoleculeDrug DB07242 (4R)-7,8-dichloro-1',9-dimethyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrile Thumb 18.5%
12 Experimental SmallMoleculeDrug DB07161 5-phenyl-1H-indazol-3-amine Thumb 17.9%
13 Approved;
SmallMoleculeDrug DB00131 Adenosine monophosphate Thumb 17.8%
14 Investigational SmallMoleculeDrug DB05243 XL019 Thumb 17.7%
15 Experimental SmallMoleculeDrug DB02482 Phosphonothreonine Thumb 16.8%
16 Experimental;
SmallMoleculeDrug DB04216 Quercetin Thumb 16.6%
17 Experimental SmallMoleculeDrug DB07125 4-(6-{[(1R)-1-(hydroxymethyl)propyl]amino}imidazo[1,2-b]pyridazin-3-yl)benzoic acid Thumb 15.8%
18 Approved SmallMoleculeDrug DB00619 Imatinib Thumb 15.8%
19 Approved;
SmallMoleculeDrug DB08901 Ponatinib Thumb 15.7%
20 Experimental SmallMoleculeDrug DB03777 Rbt205 Inhibitor Thumb 15.5%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.