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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: O75908
No. Gene UniProt ID Protein Name Pathway PDB
1 SOAT2 O75908 Sterol O-acyltransferase 2 hsa00100; hsa04979 NA

1 known interactions (drugs) of input target (SOAT2): Sterol O-acyltransferase 2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Approved SmallMoleculeDrug DB01094 Hesperetin Thumb

20 predicted interactions (drugs) of input target (SOAT2): Sterol O-acyltransferase 2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
SmallMoleculeDrug DB00157 NADH Thumb 25.1%
2 Investigational SmallMoleculeDrug DB04852 Implitapide Thumb 19.6%
3 Approved;
SmallMoleculeDrug DB08827 Lomitapide Thumb 18.8%
4 Approved SmallMoleculeDrug DB03147 Flavin adenine dinucleotide Thumb 16.8%
5 Investigational SmallMoleculeDrug DB05678 SLx-4090 Thumb 16.2%
6 Approved SmallMoleculeDrug DB00973 Ezetimibe Thumb 13.8%
7 Approved;
SmallMoleculeDrug DB00136 Calcitriol Thumb 13.1%
8 Approved;
SmallMoleculeDrug DB04824 Phenolphthalein Thumb 12.9%
9 Approved;
SmallMoleculeDrug DB01593 Zinc Thumb 12.8%
10 Approved;
SmallMoleculeDrug DB00890 Dienestrol Thumb 12.7%
11 Investigational SmallMoleculeDrug DB01645 Genistein Thumb 12.6%
12 Approved SmallMoleculeDrug DB09371 Norethynodrel Thumb 12.4%
13 Experimental SmallMoleculeDrug DB04429 4'-Hydroxyflavanone Thumb 12.3%
14 Approved;
Vet approved
SmallMoleculeDrug DB01065 Melatonin Thumb 11.8%
15 Approved;
SmallMoleculeDrug DB01411 Pranlukast Thumb 11.7%
16 Approved SmallMoleculeDrug DB00515 Cisplatin Thumb 11.7%
17 Approved SmallMoleculeDrug DB11221 Dioxybenzone Thumb 11.5%
18 Approved;
SmallMoleculeDrug DB00293 Raltitrexed Thumb 11.5%
19 Experimental SmallMoleculeDrug DB03214 Vinylglycine Thumb 11.4%
20 Approved;
SmallMoleculeDrug DB00642 Pemetrexed Thumb 10.9%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.