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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P10828
No. Gene UniProt ID Protein Name Pathway PDB
1 THRB P10828 Thyroid hormone receptor beta hsa04080; hsa04919 1BSX; 1N46; 1NAX; 1NQ0; 1NQ1; 1NQ2; 1NUO; 1Q4X; 1R6G; 1XZX; 1Y0X; 2J4A; 2NLL; 2PIN; 3D57; 3GWS; 3IMY; 3JZC; 4ZO1

14 known interactions (drugs) of input target (THRB): Thyroid hormone receptor beta
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Experimental SmallMoleculeDrug DB03788 GC-24 Thumb
2 Approved SmallMoleculeDrug DB01583 Liotrix Thumb
3 Investigational SmallMoleculeDrug DB05192 MB07811 Thumb
4 Approved;
SmallMoleculeDrug DB00509 Dextrothyroxine Thumb
5 Experimental SmallMoleculeDrug DB02106 [3,5-Dibromo-4-(4-Hydroxy-3-Phenethylcarbamoyl-Phenoxy)-Phenyl]-Acetic Acid Thumb
6 Experimental SmallMoleculeDrug DB03181 2-[4-(4-Hydroxy-3-Isopropyl-Phenoxy)-3,5-Dimethyl-Phenyl]-2h-[1,2,4]Triazine-3,5-Dione Thumb
7 Investigational SmallMoleculeDrug DB03604 Tiratricol Thumb
8 Investigational SmallMoleculeDrug DB05035 Eprotirome Thumb
9 Experimental SmallMoleculeDrug DB08085 1-(4-HEXYLPHENYL)PROP-2-EN-1-ONE Thumb
10 Approved;
SmallMoleculeDrug DB01118 Amiodarone Thumb
11 Approved SmallMoleculeDrug DB00451 Levothyroxine Thumb
12 Approved;
Vet approved
SmallMoleculeDrug DB00279 Liothyronine Thumb
13 Experimental SmallMoleculeDrug DB03176 KB-141 Thumb
14 Investigational SmallMoleculeDrug DB07425 Sobetirome Thumb

20 predicted interactions (drugs) of input target (THRB): Thyroid hormone receptor beta
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Investigational SmallMoleculeDrug DB05235 NRP409 Thumb 38.1%
2 Experimental SmallMoleculeDrug DB03461 2'-Monophosphoadenosine 5'-Diphosphoribose Thumb 28.9%
3 Approved;
SmallMoleculeDrug DB00907 Cocaine Thumb 27.9%
4 Experimental SmallMoleculeDrug DB03963 S-(Dimethylarsenic)Cysteine Thumb 26.0%
5 Approved;
SmallMoleculeDrug DB00157 NADH Thumb 26.0%
6 Investigational;
SmallMoleculeDrug DB01992 Coenzyme A Thumb 24.5%
7 Approved;
SmallMoleculeDrug DB12010 Fostamatinib Thumb 22.2%
8 Approved;
Vet approved
SmallMoleculeDrug DB00721 Procaine Thumb 22.1%
9 Approved;
SmallMoleculeDrug DB09099 Somatostatin Thumb 22.1%
10 Investigational SmallMoleculeDrug DB12695 Phenethyl Isothiocyanate Thumb 22.0%
11 Nutraceutical SmallMoleculeDrug DB13191 Phosphocreatine Thumb 21.9%
12 Approved;
Vet approved
SmallMoleculeDrug DB00145 Glycine Thumb 21.7%
13 Approved;
SmallMoleculeDrug DB09034 Suvorexant Thumb 20.9%
14 Approved;
SmallMoleculeDrug DB04896 Milnacipran Thumb 20.7%
15 Approved;
Vet approved
SmallMoleculeDrug DB01213 Fomepizole Thumb 20.3%
16 Approved SmallMoleculeDrug DB00805 Minaprine Thumb 20.3%
17 Approved SmallMoleculeDrug DB02659 Cholic Acid Thumb 20.2%
18 Approved;
SmallMoleculeDrug DB04894 Vapreotide Thumb 19.9%
19 Approved;
SmallMoleculeDrug DB01174 Phenobarbital Thumb 19.9%
20 Approved SmallMoleculeDrug DB06637 Dalfampridine Thumb 19.9%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.