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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P07814
No. Gene UniProt ID Protein Name Pathway PDB
1 EPRS P07814 Bifunctional glutamate/proline--tRNA ligase hsa00860; hsa00970; hsa01100 1FYJ; 4HVC; 4K86; 4K87; 4K88; 5A34; 5BMU


5 known interactions (drugs) of input target (EPRS): Bifunctional glutamate/proline--tRNA ligase
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Experimental SmallMoleculeDrug DB02510 '5'-O-(N-(L-Prolyl)-Sulfamoyl)Adenosine Thumb
2 Experimental SmallMoleculeDrug DB02684 5'-O-(N-(L-Cysteinyl)-Sulfamoyl)Adenosine Thumb
3 Approved;
Nutraceutical		 SmallMoleculeDrug DB00142 Glutamic Acid Thumb
4 Approved;
Nutraceutical		 SmallMoleculeDrug DB00172 L-Proline Thumb
5 Experimental SmallMoleculeDrug DB03376 '5'-O-(N-(L-Alanyl)-Sulfamoyl)Adenosine Thumb


20 predicted interactions (drugs) of input target (EPRS): Bifunctional glutamate/proline--tRNA ligase
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 SmallMoleculeDrug DB11638 Artenimol Thumb 26.1%
2 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00167 L-Isoleucine Thumb 22.9%
3 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00091 Cyclosporine Thumb 22.7%
4 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00119 Pyruvic acid Thumb 19.3%
5 Approved;
Nutraceutical		 SmallMoleculeDrug DB00139 Succinic acid Thumb 18.4%
6 Approved SmallMoleculeDrug DB00514 Dextromethorphan Thumb 17.2%
7 Approved SmallMoleculeDrug DB09118 Stiripentol Thumb 17.2%
8 Illicit;
Investigational		 SmallMoleculeDrug DB05047 CX717 Thumb 16.6%
9 Experimental SmallMoleculeDrug DB04166 Anthranilic acid Thumb 16.1%
10 Approved SmallMoleculeDrug DB00780 Phenelzine Thumb 15.4%
11 Investigational SmallMoleculeDrug DB12695 Phenethyl Isothiocyanate Thumb 15.2%
12 Experimental SmallMoleculeDrug DB03486 Phosphomethylphosphonic Acid Guanosyl Ester Thumb 15.1%
13 Experimental SmallMoleculeDrug DB08342 S-PALMITOYL-L-CYSTEINE Thumb 14.8%
14 Approved BiotechDrug DB00009 Alteplase Thumb 14.8%
15 Approved SmallMoleculeDrug DB13146 Fluciclovine (18F) Thumb 14.8%
16 Approved;
Investigational		 SmallMoleculeDrug DB02701 Nicotinamide Thumb 14.6%
17 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00143 Glutathione Thumb 14.5%
18 Approved;
Nutraceutical		 SmallMoleculeDrug DB00159 Icosapent Thumb 14.4%
19 Approved SmallMoleculeDrug DB00929 Misoprostol Thumb 14.4%
20 Investigational BiotechDrug DB06245 Lanoteplase Thumb 14.0%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.