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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

10 known interactions (drugs) of input target (BRAF): Serine/threonine-protein kinase B-raf
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Approved SmallMoleculeDrug DB08881 Vemurafenib Thumb
2 Approved SmallMoleculeDrug DB08896 Regorafenib Thumb
3 Experimental SmallMoleculeDrug DB06999 N-{3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide Thumb
4 Experimental SmallMoleculeDrug DB07000 N-{2,4-difluoro-3-[(5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]phenyl}ethanesulfonamide Thumb
5 Approved;
SmallMoleculeDrug DB12010 Fostamatinib Thumb
6 Approved;
SmallMoleculeDrug DB00398 Sorafenib Thumb
7 Investigational SmallMoleculeDrug DB05984 RAF-265 Thumb
8 Investigational SmallMoleculeDrug DB05190 XL281 Thumb
9 Experimental SmallMoleculeDrug DB08553 (1E)-5-(1-piperidin-4-yl-3-pyridin-4-yl-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime Thumb
10 Approved;
SmallMoleculeDrug DB08912 Dabrafenib Thumb

20 predicted interactions (drugs) of input target (BRAF): Serine/threonine-protein kinase B-raf
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
SmallMoleculeDrug DB01268 Sunitinib Thumb 35.6%
2 Approved;
SmallMoleculeDrug DB01254 Dasatinib Thumb 34.6%
3 Investigational SmallMoleculeDrug DB05014 XL999 Thumb 34.2%
4 Approved SmallMoleculeDrug DB09079 Nintedanib Thumb 33.6%
5 Approved;
SmallMoleculeDrug DB08901 Ponatinib Thumb 31.4%
6 Investigational BiotechDrug DB04973 LErafAON Thumb 29.9%
7 Approved;
SmallMoleculeDrug DB09078 Lenvatinib Thumb 29.9%
8 Approved SmallMoleculeDrug DB00619 Imatinib Thumb 29.5%
9 Approved SmallMoleculeDrug DB06589 Pazopanib Thumb 29.4%
10 Investigational SmallMoleculeDrug DB05146 XL820 Thumb 28.9%
11 Approved;
SmallMoleculeDrug DB06595 Midostaurin Thumb 28.9%
12 Investigational SmallMoleculeDrug DB06080 ABT-869 Thumb 28.8%
13 Experimental SmallMoleculeDrug DB02482 Phosphonothreonine Thumb 27.8%
14 Approved SmallMoleculeDrug DB05294 Vandetanib Thumb 26.1%
15 Experimental;
SmallMoleculeDrug DB04216 Quercetin Thumb 26.1%
16 Approved;
SmallMoleculeDrug DB00786 Marimastat Thumb 25.7%
17 Investigational SmallMoleculeDrug DB04879 Vatalanib Thumb 25.2%
18 Investigational SmallMoleculeDrug DB05075 TG-100801 Thumb 24.0%
19 Experimental SmallMoleculeDrug DB04147 Lauryl Dimethylamine-N-Oxide Thumb 23.6%
20 Experimental SmallMoleculeDrug DB01809 1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine Thumb 23.2%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.