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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P00740
No. Gene UniProt ID Protein Name Pathway PDB
1 F9 P00740 Coagulation factor IX hsa04610


11 known interactions (drugs) of input target (F9): Coagulation factor IX
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image
1 Approved;
Investigational
BiotechDrug DB13150 Coagulation factor VII human Thumb
2 Approved BiotechDrug DB13999 Moroctocog alfa Thumb
3 Approved;
Investigational
BiotechDrug DB09109 Turoctocog alfa Thumb
4 Approved;
Investigational
BiotechDrug DB13923 Emicizumab Thumb
5 Approved;
Investigational
BiotechDrug DB13998 Lonoctocog alfa Thumb
6 Approved;
Nutraceutical
SmallMoleculeDrug DB00170 Menadione Thumb
7 Approved;
Investigational
BiotechDrug DB09329 Antihemophilic Factor (Recombinant), PEGylated Thumb
8 Investigational SmallMoleculeDrug DB05131 TTP889 Thumb
9 Approved BiotechDrug DB13192 Antihemophilic factor human Thumb
10 Approved;
Investigational
BiotechDrug DB00025 Antihemophilic factor, human recombinant Thumb
11 Approved SmallMoleculeDrug DB09332 Kappadione Thumb


20 predicted interactions (drugs) of input target (F9): Coagulation factor IX
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Investigational BiotechDrug DB06245 Lanoteplase Thumb 54.2%
2 Approved BiotechDrug DB13149 Protein S human Thumb 51.5%
3 Approved BiotechDrug DB00036 Coagulation factor VIIa Recombinant Human Thumb 48.5%
4 Approved BiotechDrug DB13152 Coagulation Factor IX Human Thumb 43.7%
5 Approved;
Investigational
SmallMoleculeDrug DB00464 Sodium Tetradecyl Sulfate Thumb 39.7%
6 Approved;
Investigational
BiotechDrug DB00100 Coagulation Factor IX (Recombinant) Thumb 38.1%
7 Experimental SmallMoleculeDrug DB03847 Gamma-Carboxy-Glutamic Acid Thumb 37.9%
8 Experimental SmallMoleculeDrug DB07277 2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}ETHANESULFONAMIDE Thumb 37.6%
9 Approved;
Investigational
BiotechDrug DB13933 Nonacog beta pegol Thumb 35.3%
10 Approved BiotechDrug DB00031 Tenecteplase Thumb 34.7%
11 Approved;
Investigational
SmallMoleculeDrug DB01593 Zinc Thumb 34.4%
12 Approved;
Investigational
BiotechDrug DB13151 Anti-inhibitor coagulant complex Thumb 33.4%
13 Experimental SmallMoleculeDrug DB08488 4-{[(E)-2-(5-CHLOROTHIEN-2-YL)VINYL]SULFONYL}-1-(1H-PYRROLO[3,2-C]PYRIDIN-2-YLMETHYL)PIPERAZIN-2-ONE Thumb 32.8%
14 Approved SmallMoleculeDrug DB09075 Edoxaban Thumb 32.6%
15 Experimental SmallMoleculeDrug DB08174 5-CHLORO-N-((1R,2S)-2-(4-(2-OXOPYRIDIN-1(2H)-YL)BENZAMIDO) CYCLOPENTYL)THIOPHENE-2-CARBOXAMIDE Thumb 32.5%
16 Experimental SmallMoleculeDrug DB07261 THIENO[3,2-B]PYRIDINE-2-SULFONIC ACID [1-(1-AMINO-ISOQUINOLIN-7-YLMETHYL)-2-OXO-PYRROLDIN-3-YL]-AMIDE Thumb 32.4%
17 Experimental SmallMoleculeDrug DB08143 5-CHLORO-THIOPHENE-2-CARBOXYLIC ACID ((3S,4S)-4-FLUORO- 1-{[2-FLUORO-4-(2-OXO-2H-PYRIDIN-1-YL)-PHENYLCARBAMOYL]-METHYL}-PYRROLIDIN-3-YL)-AMIDE Thumb 32.1%
18 Experimental SmallMoleculeDrug DB07843 5-CHLORO-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}-1-BENZOTHIOPHENE-2-SULFONAMIDE Thumb 32.0%
19 Approved;
Investigational;
Withdrawn
BiotechDrug DB00055 Drotrecogin alfa Thumb 31.7%
20 Experimental SmallMoleculeDrug DB07629 N-((1R,2S)-2-(5-CHLORO-1H-INDOLE-2-CARBOXAMIDO)CYCLOHEXYL)-5-METHYL-4,5,6,7-TETRAHYDROTHIAZOLO[5,4-C]PYRIDINE-2-CARBOXAMIDE Thumb 31.5%



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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.