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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q02641
No. Gene UniProt ID Protein Name Pathway PDB
1 CACNB1 Q02641 Voltage-dependent L-type calcium channel subunit beta-1 hsa04010; hsa04260; hsa04261; hsa04921; hsa05410; hsa05412; hsa05414 NA


18 known interactions (drugs) of input target (CACNB1): Voltage-dependent L-type calcium channel subunit beta-1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational		 SmallMoleculeDrug DB09238 Manidipine Thumb
2 Approved SmallMoleculeDrug DB00421 Spironolactone Thumb
3 Approved;
Investigational		 SmallMoleculeDrug DB09236 Lacidipine Thumb
4 Approved;
Investigational		 SmallMoleculeDrug DB09231 Benidipine Thumb
5 Investigational;
Withdrawn		 SmallMoleculeDrug DB01388 Mibefradil Thumb
6 Approved SmallMoleculeDrug DB00308 Ibutilide Thumb
7 Approved;
Investigational		 SmallMoleculeDrug DB09230 Azelnidipine Thumb
8 Approved SmallMoleculeDrug DB00825 Menthol Thumb
9 Approved;
Investigational		 SmallMoleculeDrug DB00393 Nimodipine Thumb
10 Approved SmallMoleculeDrug DB00898 Ethanol Thumb
11 Approved SmallMoleculeDrug DB09089 Trimebutine Thumb
12 Approved;
Withdrawn		 SmallMoleculeDrug DB11148 Butamben Thumb
13 Approved;
Investigational		 SmallMoleculeDrug DB09232 Cilnidipine Thumb
14 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00653 Magnesium sulfate Thumb
15 Approved;
Nutraceutical		 SmallMoleculeDrug DB13961 Fish oil Thumb
16 Approved SmallMoleculeDrug DB04855 Dronedarone Thumb
17 Approved;
Experimental		 SmallMoleculeDrug DB13746 Bioallethrin Thumb
18 Approved SmallMoleculeDrug DB00661 Verapamil Thumb


20 predicted interactions (drugs) of input target (CACNB1): Voltage-dependent L-type calcium channel subunit beta-1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 SmallMoleculeDrug DB00568 Cinnarizine Thumb 68.9%
2 Approved;
Investigational		 SmallMoleculeDrug DB09229 Aranidipine Thumb 68.6%
3 Approved SmallMoleculeDrug DB01115 Nifedipine Thumb 68.2%
4 Approved;
Investigational		 SmallMoleculeDrug DB06712 Nilvadipine Thumb 67.8%
5 Approved SmallMoleculeDrug DB00381 Amlodipine Thumb 67.3%
6 Approved;
Investigational		 SmallMoleculeDrug DB01054 Nitrendipine Thumb 66.7%
7 Approved;
Investigational		 SmallMoleculeDrug DB04920 Clevidipine Thumb 63.5%
8 Approved SmallMoleculeDrug DB00401 Nisoldipine Thumb 63.1%
9 Approved;
Investigational		 SmallMoleculeDrug DB00270 Isradipine Thumb 61.9%
10 Approved;
Investigational		 SmallMoleculeDrug DB01023 Felodipine Thumb 60.1%
11 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01110 Miconazole Thumb 52.9%
12 Approved;
Investigational		 SmallMoleculeDrug DB00622 Nicardipine Thumb 50.7%
13 Approved;
Investigational		 SmallMoleculeDrug DB09235 Efonidipine Thumb 48.6%
14 Approved;
Investigational		 SmallMoleculeDrug DB11633 Isavuconazole Thumb 47.0%
15 Approved;
Withdrawn		 SmallMoleculeDrug DB01244 Bepridil Thumb 44.9%
16 Approved SmallMoleculeDrug DB09090 Pinaverium Thumb 44.3%
17 Approved;
Investigational		 SmallMoleculeDrug DB09237 Levamlodipine Thumb 43.9%
18 Approved SmallMoleculeDrug DB04841 Flunarizine Thumb 41.6%
19 Approved SmallMoleculeDrug DB09227 Barnidipine Thumb 38.2%
20 Approved;
Investigational		 SmallMoleculeDrug DB00996 Gabapentin Thumb 36.1%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.