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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P0DP23
No. Gene UniProt ID Protein Name Pathway PDB
1 CALM1 P0DP23 Calmodulin NA


28 known interactions (drugs) of input target (CALM1): Calmodulin
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved SmallMoleculeDrug DB00836 Loperamide Thumb
2 Withdrawn SmallMoleculeDrug DB04825 Prenylamine Thumb
3 Approved SmallMoleculeDrug DB01100 Pimozide Thumb
4 Approved;
Withdrawn		 SmallMoleculeDrug DB01244 Bepridil Thumb
5 Approved SmallMoleculeDrug DB00850 Perphenazine Thumb
6 Approved;
Nutraceutical		 SmallMoleculeDrug DB01373 Calcium Thumb
7 Approved;
Investigational		 SmallMoleculeDrug DB00622 Nicardipine Thumb
8 Experimental SmallMoleculeDrug DB02868 3''-(Beta-Chloroethyl)-2'',4''-Dioxo-3, 5''-Spiro-Oxazolidino-4-Deacetoxy-Vinblastine Thumb
9 Approved SmallMoleculeDrug DB01115 Nifedipine Thumb
10 Approved;
Vet approved		 SmallMoleculeDrug DB00527 Cinchocaine Thumb
11 Experimental SmallMoleculeDrug DB03977 N-Trimethyllysine Thumb
12 Approved;
Experimental		 SmallMoleculeDrug DB13800 Calcium levulinate Thumb
13 Approved;
Nutraceutical;
Vet approved		 SmallMoleculeDrug DB01065 Melatonin Thumb
14 Approved;
Investigational		 SmallMoleculeDrug DB01023 Felodipine Thumb
15 Approved SmallMoleculeDrug DB04841 Flunarizine Thumb
16 Experimental SmallMoleculeDrug DB03900 2-Methyl-2-Propanol Thumb
17 Approved;
Investigational		 SmallMoleculeDrug DB01069 Promethazine Thumb
18 Approved SmallMoleculeDrug DB01429 Aprindine Thumb
19 Approved;
Vet approved		 SmallMoleculeDrug DB00753 Isoflurane Thumb
20 Experimental SmallMoleculeDrug DB08039 (3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE Thumb
21 Approved SmallMoleculeDrug DB11348 Calcium Phosphate Thumb
22 Approved SmallMoleculeDrug DB00623 Fluphenazine Thumb
23 Experimental SmallMoleculeDrug DB04513 N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide Thumb
24 Approved SmallMoleculeDrug DB11093 Calcium Citrate Thumb
25 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00477 Chlorpromazine Thumb
26 Experimental SmallMoleculeDrug DB08231 Myristic acid Thumb
27 Approved SmallMoleculeDrug DB00925 Phenoxybenzamine Thumb
28 Approved;
Investigational		 SmallMoleculeDrug DB00831 Trifluoperazine Thumb


20 predicted interactions (drugs) of input target (CALM1): Calmodulin
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 SmallMoleculeDrug DB00334 Olanzapine Thumb 68.8%
2 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb 64.4%
3 Approved;
Investigational		 SmallMoleculeDrug DB00555 Lamotrigine Thumb 58.1%
4 Approved SmallMoleculeDrug DB00661 Verapamil Thumb 56.8%
5 Approved SmallMoleculeDrug DB00898 Ethanol Thumb 56.2%
6 Approved;
Investigational		 SmallMoleculeDrug DB00568 Cinnarizine Thumb 54.1%
7 Approved SmallMoleculeDrug DB04855 Dronedarone Thumb 53.8%
8 Approved;
Investigational		 SmallMoleculeDrug DB09229 Aranidipine Thumb 53.8%
9 Approved;
Vet approved		 SmallMoleculeDrug DB01159 Halothane Thumb 51.0%
10 Approved;
Investigational		 SmallMoleculeDrug DB00996 Gabapentin Thumb 48.1%
11 Approved;
Investigational		 SmallMoleculeDrug DB01142 Doxepin Thumb 47.4%
12 Approved SmallMoleculeDrug DB00381 Amlodipine Thumb 47.1%
13 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB00182 Amphetamine Thumb 46.9%
14 Approved;
Investigational		 SmallMoleculeDrug DB12278 Propiverine Thumb 46.4%
15 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb 45.8%
16 Approved SmallMoleculeDrug DB00988 Dopamine Thumb 45.6%
17 Approved;
Vet approved		 SmallMoleculeDrug DB01221 Ketamine Thumb 44.3%
18 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb 43.9%
19 Approved;
Investigational		 SmallMoleculeDrug DB11638 Artenimol Thumb 43.6%
20 Approved SmallMoleculeDrug DB00370 Mirtazapine Thumb 43.6%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.