QuartataWeb
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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P78508
No. Gene UniProt ID Protein Name Pathway PDB
1 KCNJ10 P78508 ATP-sensitive inward rectifier potassium channel 10 hsa04971 NA


2 known interactions (drugs) of input target (KCNJ10): ATP-sensitive inward rectifier potassium channel 10
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Withdrawn		 SmallMoleculeDrug DB11148 Butamben Thumb
2 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01392 Yohimbine Thumb


20 predicted interactions (drugs) of input target (KCNJ10): ATP-sensitive inward rectifier potassium channel 10
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB00661 Verapamil Thumb 28.4%
2 Approved SmallMoleculeDrug DB00308 Ibutilide Thumb 27.9%
3 Approved SmallMoleculeDrug DB00222 Glimepiride Thumb 25.4%
4 Approved SmallMoleculeDrug DB00421 Spironolactone Thumb 24.0%
5 Approved;
Investigational		 SmallMoleculeDrug DB00922 Levosimendan Thumb 23.4%
6 Experimental;
Investigational		 SmallMoleculeDrug DB03496 Alvocidib Thumb 23.2%
7 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00114 Pyridoxal Phosphate Thumb 22.0%
8 Approved;
Vet approved		 SmallMoleculeDrug DB01154 Thiamylal Thumb 21.2%
9 Experimental;
Investigational		 BiotechDrug DB14009 Medical Cannabis Thumb 21.2%
10 Approved;
Investigational		 SmallMoleculeDrug DB14011 Nabiximols Thumb 20.8%
11 Approved;
Experimental		 SmallMoleculeDrug DB13746 Bioallethrin Thumb 20.5%
12 Approved;
Investigational		 SmallMoleculeDrug DB11633 Isavuconazole Thumb 20.4%
13 Approved SmallMoleculeDrug DB04855 Dronedarone Thumb 20.4%
14 Approved;
Investigational		 SmallMoleculeDrug DB09238 Manidipine Thumb 20.2%
15 Approved;
Investigational		 SmallMoleculeDrug DB00204 Dofetilide Thumb 20.2%
16 Experimental;
Investigational		 SmallMoleculeDrug DB08838 Agmatine Thumb 19.6%
17 Investigational;
Withdrawn		 SmallMoleculeDrug DB01388 Mibefradil Thumb 19.5%
18 Approved;
Investigational		 SmallMoleculeDrug DB09061 Cannabidiol Thumb 19.3%
19 Approved SmallMoleculeDrug DB01119 Diazoxide Thumb 19.3%
20 Approved SmallMoleculeDrug DB00825 Menthol Thumb 19.2%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.