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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q8NET8
No. Gene UniProt ID Protein Name Pathway PDB
1 TRPV3 Q8NET8 Transient receptor potential cation channel subfamily V member 3 hsa04750 NA


7 known interactions (drugs) of input target (TRPV3): Transient receptor potential cation channel subfamily V member 3
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Experimental;
Investigational		 BiotechDrug DB14009 Medical Cannabis Thumb
2 Approved SmallMoleculeDrug DB00825 Menthol Thumb
3 Approved SmallMoleculeDrug DB01744 Camphor Thumb
4 Experimental SmallMoleculeDrug DB11345 (S)-camphor Thumb
5 Approved SmallMoleculeDrug DB09086 Eugenol Thumb
6 Approved;
Investigational		 SmallMoleculeDrug DB09061 Cannabidiol Thumb
7 Approved;
Investigational		 SmallMoleculeDrug DB14011 Nabiximols Thumb


20 predicted interactions (drugs) of input target (TRPV3): Transient receptor potential cation channel subfamily V member 3
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Investigational SmallMoleculeDrug DB11755 Tetrahydrocannabivarin Thumb 59.5%
2 Investigational SmallMoleculeDrug DB14050 Cannabidivarin Thumb 43.9%
3 Experimental SmallMoleculeDrug DB02955 Ricinoleic Acid Thumb 36.3%
4 Approved SmallMoleculeDrug DB00421 Spironolactone Thumb 35.2%
5 Approved;
Withdrawn		 SmallMoleculeDrug DB11148 Butamben Thumb 34.0%
6 Approved;
Experimental		 SmallMoleculeDrug DB13746 Bioallethrin Thumb 29.0%
7 Approved SmallMoleculeDrug DB09089 Trimebutine Thumb 27.5%
8 Investigational;
Withdrawn		 SmallMoleculeDrug DB01388 Mibefradil Thumb 27.1%
9 Approved;
Investigational		 SmallMoleculeDrug DB06202 Lasofoxifene Thumb 26.9%
10 Approved;
Investigational		 SmallMoleculeDrug DB09231 Benidipine Thumb 26.9%
11 Approved SmallMoleculeDrug DB00661 Verapamil Thumb 26.8%
12 Approved;
Investigational		 SmallMoleculeDrug DB09288 Propacetamol Thumb 26.4%
13 Approved;
Investigational		 SmallMoleculeDrug DB09236 Lacidipine Thumb 26.3%
14 Approved;
Investigational		 SmallMoleculeDrug DB01593 Zinc Thumb 26.2%
15 Approved BiotechDrug DB11131 Capsicum oleoresin Thumb 26.0%
16 Approved;
Vet approved		 SmallMoleculeDrug DB00396 Progesterone Thumb 26.0%
17 Approved;
Investigational		 SmallMoleculeDrug DB00393 Nimodipine Thumb 25.6%
18 Approved;
Nutraceutical		 SmallMoleculeDrug DB13961 Fish oil Thumb 25.4%
19 Approved;
Investigational		 SmallMoleculeDrug DB09238 Manidipine Thumb 25.1%
20 Approved SmallMoleculeDrug DB04855 Dronedarone Thumb 24.8%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.