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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P35348
No. Gene UniProt ID Protein Name Pathway PDB
1 ADRA1A P35348 Alpha-1A adrenergic receptor hsa04020; hsa04022; hsa04080; hsa04152; hsa04261; hsa04270; hsa04970 NA


113 known interactions (drugs) of input target (ADRA1A): Alpha-1A adrenergic receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Illicit		 SmallMoleculeDrug DB01576 Dextroamphetamine Thumb
2 Approved SmallMoleculeDrug DB01267 Paliperidone Thumb
3 Approved SmallMoleculeDrug DB01224 Quetiapine Thumb
4 Approved;
Investigational		 SmallMoleculeDrug DB01200 Bromocriptine Thumb
5 Approved SmallMoleculeDrug DB04855 Dronedarone Thumb
6 Approved SmallMoleculeDrug DB00363 Clozapine Thumb
7 Approved;
Investigational		 SmallMoleculeDrug DB00751 Epinastine Thumb
8 Approved SmallMoleculeDrug DB04946 Iloperidone Thumb
9 Withdrawn SmallMoleculeDrug DB08950 Indoramin Thumb
10 Approved SmallMoleculeDrug DB01162 Terazosin Thumb
11 Approved;
Investigational		 SmallMoleculeDrug DB00935 Oxymetazoline Thumb
12 Approved;
Illicit		 SmallMoleculeDrug DB01579 Phendimetrazine Thumb
13 Approved SmallMoleculeDrug DB11124 Racepinephrine Thumb
14 Approved SmallMoleculeDrug DB00800 Fenoldopam Thumb
15 Approved;
Investigational		 SmallMoleculeDrug DB12278 Propiverine Thumb
16 Approved SmallMoleculeDrug DB01364 Ephedrine Thumb
17 Approved;
Investigational		 SmallMoleculeDrug DB00734 Risperidone Thumb
18 Approved SmallMoleculeDrug DB09167 Dosulepin Thumb
19 Approved;
Investigational		 SmallMoleculeDrug DB09205 Moxisylyte Thumb
20 Experimental;
Illicit		 SmallMoleculeDrug DB01472 4-Methoxyamphetamine Thumb
21 Approved;
Investigational		 SmallMoleculeDrug DB01142 Doxepin Thumb
22 Approved;
Investigational		 SmallMoleculeDrug DB00831 Trifluoperazine Thumb
23 Approved;
Investigational		 SmallMoleculeDrug DB00334 Olanzapine Thumb
24 Approved SmallMoleculeDrug DB00408 Loxapine Thumb
25 Approved;
Investigational		 SmallMoleculeDrug DB00622 Nicardipine Thumb
26 Approved;
Investigational		 SmallMoleculeDrug DB00610 Metaraminol Thumb
27 Approved;
Investigational		 SmallMoleculeDrug DB00908 Quinidine Thumb
28 Approved;
Investigational		 SmallMoleculeDrug DB00656 Trazodone Thumb
29 Approved SmallMoleculeDrug DB06706 Isometheptene Thumb
30 Approved;
Investigational		 SmallMoleculeDrug DB01175 Escitalopram Thumb
31 Approved;
Vet approved		 SmallMoleculeDrug DB00450 Droperidol Thumb
32 Approved SmallMoleculeDrug DB00692 Phentolamine Thumb
33 Approved;
Withdrawn		 SmallMoleculeDrug DB01149 Nefazodone Thumb
34 Approved SmallMoleculeDrug DB00661 Verapamil Thumb
35 Approved;
Investigational		 SmallMoleculeDrug DB00706 Tamsulosin Thumb
36 Approved;
Illicit		 SmallMoleculeDrug DB00865 Benzphetamine Thumb
37 Experimental SmallMoleculeDrug DB09239 Niguldipine Thumb
38 Approved SmallMoleculeDrug DB01622 Thioproperazine Thumb
39 Approved;
Investigational		 SmallMoleculeDrug DB01238 Aripiprazole Thumb
40 Approved SmallMoleculeDrug DB08922 Perospirone Thumb
41 Approved SmallMoleculeDrug DB01253 Ergonovine Thumb
42 Approved;
Investigational		 SmallMoleculeDrug DB00555 Lamotrigine Thumb
43 Approved SmallMoleculeDrug DB00457 Prazosin Thumb
44 Approved;
Investigational		 SmallMoleculeDrug DB09229 Aranidipine Thumb
45 Approved SmallMoleculeDrug DB00211 Midodrine Thumb
46 Approved;
Investigational		 SmallMoleculeDrug DB01624 Zuclopenthixol Thumb
47 Approved SmallMoleculeDrug DB00246 Ziprasidone Thumb
48 Approved SmallMoleculeDrug DB00370 Mirtazapine Thumb
49 Approved SmallMoleculeDrug DB01049 Ergoloid mesylate Thumb
50 Approved SmallMoleculeDrug DB06711 Naphazoline Thumb
51 Approved SmallMoleculeDrug DB00925 Phenoxybenzamine Thumb
52 Approved;
Investigational		 SmallMoleculeDrug DB01151 Desipramine Thumb
53 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb
54 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb
55 Approved SmallMoleculeDrug DB00368 Norepinephrine Thumb
56 Approved SmallMoleculeDrug DB00248 Cabergoline Thumb
57 Approved SmallMoleculeDrug DB06764 Tetryzoline Thumb
58 Approved;
Investigational		 SmallMoleculeDrug DB06148 Mianserin Thumb
59 Approved SmallMoleculeDrug DB00458 Imipramine Thumb
60 Approved SmallMoleculeDrug DB06207 Silodosin Thumb
61 Approved;
Withdrawn		 SmallMoleculeDrug DB00679 Thioridazine Thumb
62 Approved;
Investigational		 SmallMoleculeDrug DB09286 Pipamperone Thumb
63 Approved SmallMoleculeDrug DB01295 Bevantolol Thumb
64 Approved SmallMoleculeDrug DB01365 Mephentermine Thumb
65 Approved SmallMoleculeDrug DB00852 Pseudoephedrine Thumb
66 Approved SmallMoleculeDrug DB00964 Apraclonidine Thumb
67 Approved SmallMoleculeDrug DB00215 Citalopram Thumb
68 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB06144 Sertindole Thumb
69 Withdrawn SmallMoleculeDrug DB09194 Etoperidone Thumb
70 Approved SmallMoleculeDrug DB09195 Lorpiprazole Thumb
71 Approved;
Investigational		 SmallMoleculeDrug DB01069 Promethazine Thumb
72 Experimental SmallMoleculeDrug DB09202 Cirazoline Thumb
73 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb
74 Approved SmallMoleculeDrug DB00575 Clonidine Thumb
75 Approved SmallMoleculeDrug DB06216 Asenapine Thumb
76 Approved SmallMoleculeDrug DB00590 Doxazosin Thumb
77 Approved SmallMoleculeDrug DB00841 Dobutamine Thumb
78 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00477 Chlorpromazine Thumb
79 Approved SmallMoleculeDrug DB00298 Dapiprazole Thumb
80 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb
81 Approved SmallMoleculeDrug DB00388 Phenylephrine Thumb
82 Approved;
Investigational		 SmallMoleculeDrug DB00934 Maprotiline Thumb
83 Approved SmallMoleculeDrug DB00696 Ergotamine Thumb
84 Investigational SmallMoleculeDrug DB09204 Arotinolol Thumb
85 Approved;
Vet approved		 SmallMoleculeDrug DB00668 Epinephrine Thumb
86 Approved;
Investigational		 SmallMoleculeDrug DB04948 Lofexidine Thumb
87 Approved;
Experimental		 SmallMoleculeDrug DB13345 Dihydroergocristine Thumb
88 Investigational SmallMoleculeDrug DB06229 Ocaperidone Thumb
89 Approved SmallMoleculeDrug DB06153 Pizotifen Thumb
90 Approved;
Investigational		 SmallMoleculeDrug DB06694 Xylometazoline Thumb
91 Approved;
Investigational		 SmallMoleculeDrug DB00346 Alfuzosin Thumb
92 Approved;
Investigational		 SmallMoleculeDrug DB13025 Tiapride Thumb
93 Experimental SmallMoleculeDrug DB09203 Synephrine Thumb
94 Approved;
Vet approved		 SmallMoleculeDrug DB00797 Tolazoline Thumb
95 Approved;
Investigational		 SmallMoleculeDrug DB00699 Nicergoline Thumb
96 Approved SmallMoleculeDrug DB00449 Dipivefrin Thumb
97 Approved;
Vet approved		 SmallMoleculeDrug DB01614 Acepromazine Thumb
98 Approved SmallMoleculeDrug DB11577 Indigotindisulfonic Acid Thumb
99 Investigational SmallMoleculeDrug DB05492 Epicept NP-1 Thumb
100 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB00875 Flupentixol Thumb
101 Approved;
Investigational		 SmallMoleculeDrug DB01136 Carvedilol Thumb
102 Approved;
Investigational		 SmallMoleculeDrug DB14185 Aripiprazole lauroxil Thumb
103 Approved;
Investigational		 SmallMoleculeDrug DB00723 Methoxamine Thumb
104 Approved;
Vet approved		 SmallMoleculeDrug DB00420 Promazine Thumb
105 Approved SmallMoleculeDrug DB11273 Dihydroergocornine Thumb
106 Approved;
Investigational;
Vet approved;
Withdrawn		 SmallMoleculeDrug DB01186 Pergolide Thumb
107 Investigational SmallMoleculeDrug DB05469 R450 Thumb
108 Approved SmallMoleculeDrug DB00598 Labetalol Thumb
109 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB00182 Amphetamine Thumb
110 Approved SmallMoleculeDrug DB11278 DL-Methylephedrine Thumb
111 Approved;
Investigational		 SmallMoleculeDrug DB01403 Methotrimeprazine Thumb
112 Approved;
Investigational		 SmallMoleculeDrug DB06262 Droxidopa Thumb
113 Approved SmallMoleculeDrug DB00777 Propiomazine Thumb


20 predicted interactions (drugs) of input target (ADRA1A): Alpha-1A adrenergic receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 SmallMoleculeDrug DB09128 Brexpiprazole Thumb 88.3%
2 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB09225 Zotepine Thumb 85.7%
3 Approved;
Investigational		 SmallMoleculeDrug DB00745 Modafinil Thumb 85.1%
4 Approved;
Investigational		 SmallMoleculeDrug DB01608 Propericiazine Thumb 83.6%
5 Approved;
Investigational		 SmallMoleculeDrug DB00413 Pramipexole Thumb 82.4%
6 Approved;
Investigational		 SmallMoleculeDrug DB00589 Lisuride Thumb 82.4%
7 Approved;
Investigational		 SmallMoleculeDrug DB01255 Lisdexamfetamine Thumb 82.0%
8 Approved SmallMoleculeDrug DB09304 Setiptiline Thumb 80.8%
9 Approved;
Investigational		 SmallMoleculeDrug DB00268 Ropinirole Thumb 79.8%
10 Approved;
Investigational		 SmallMoleculeDrug DB08815 Lurasidone Thumb 79.6%
11 Approved;
Vet approved;
Withdrawn		 SmallMoleculeDrug DB00397 Phenylpropanolamine Thumb 78.5%
12 Approved;
Investigational		 SmallMoleculeDrug DB00714 Apomorphine Thumb 77.7%
13 Approved SmallMoleculeDrug DB05271 Rotigotine Thumb 76.8%
14 Approved;
Nutraceutical;
Withdrawn		 SmallMoleculeDrug DB01363 Ephedra Thumb 75.6%
15 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB01239 Chlorprothixene Thumb 74.3%
16 Investigational SmallMoleculeDrug DB05461 OPC-28326 Thumb 73.3%
17 Approved SmallMoleculeDrug DB00434 Cyproheptadine Thumb 72.9%
18 Investigational SmallMoleculeDrug DB06678 Esmirtazapine Thumb 71.8%
19 Approved;
Investigational		 SmallMoleculeDrug DB00629 Guanabenz Thumb 70.8%
20 Approved;
Investigational		 SmallMoleculeDrug DB00320 Dihydroergotamine Thumb 70.4%


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.