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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P21918
No. Gene UniProt ID Protein Name Pathway PDB
1 DRD5 P21918 D(1B) dopamine receptor hsa04020; hsa04024; hsa04080; hsa04728 NA


35 known interactions (drugs) of input target (DRD5): D(1B) dopamine receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved SmallMoleculeDrug DB00696 Ergotamine Thumb
2 Approved;
Investigational		 SmallMoleculeDrug DB00714 Apomorphine Thumb
3 Approved;
Investigational		 SmallMoleculeDrug DB00589 Lisuride Thumb
4 Approved SmallMoleculeDrug DB00408 Loxapine Thumb
5 Approved;
Experimental		 SmallMoleculeDrug DB13345 Dihydroergocristine Thumb
6 Approved SmallMoleculeDrug DB11275 Epicriptine Thumb
7 Approved SmallMoleculeDrug DB00248 Cabergoline Thumb
8 Approved SmallMoleculeDrug DB01224 Quetiapine Thumb
9 Approved;
Investigational		 SmallMoleculeDrug DB06148 Mianserin Thumb
10 Approved SmallMoleculeDrug DB00458 Imipramine Thumb
11 Approved SmallMoleculeDrug DB00988 Dopamine Thumb
12 Withdrawn SmallMoleculeDrug DB01038 Carphenazine Thumb
13 Approved;
Investigational		 SmallMoleculeDrug DB09097 Quinagolide Thumb
14 Approved;
Investigational		 SmallMoleculeDrug DB01200 Bromocriptine Thumb
15 Approved;
Investigational		 SmallMoleculeDrug DB00568 Cinnarizine Thumb
16 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB09225 Zotepine Thumb
17 Approved;
Investigational		 SmallMoleculeDrug DB01238 Aripiprazole Thumb
18 Approved SmallMoleculeDrug DB01235 Levodopa Thumb
19 Approved SmallMoleculeDrug DB11274 Dihydro-alpha-ergocryptine Thumb
20 Approved SmallMoleculeDrug DB11584 Pipradrol Thumb
21 Approved SmallMoleculeDrug DB00800 Fenoldopam Thumb
22 Approved;
Investigational		 SmallMoleculeDrug DB00555 Lamotrigine Thumb
23 Approved SmallMoleculeDrug DB05271 Rotigotine Thumb
24 Approved;
Investigational		 SmallMoleculeDrug DB14185 Aripiprazole lauroxil Thumb
25 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb
26 Approved;
Investigational		 SmallMoleculeDrug DB01624 Zuclopenthixol Thumb
27 Approved SmallMoleculeDrug DB00246 Ziprasidone Thumb
28 Approved;
Investigational		 SmallMoleculeDrug DB00268 Ropinirole Thumb
29 Approved SmallMoleculeDrug DB00370 Mirtazapine Thumb
30 Approved SmallMoleculeDrug DB01049 Ergoloid mesylate Thumb
31 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00477 Chlorpromazine Thumb
32 Approved;
Investigational;
Vet approved;
Withdrawn		 SmallMoleculeDrug DB01186 Pergolide Thumb
33 Approved;
Investigational		 SmallMoleculeDrug DB00413 Pramipexole Thumb
34 Approved;
Investigational		 SmallMoleculeDrug DB01403 Methotrimeprazine Thumb
35 Approved;
Investigational		 SmallMoleculeDrug DB00334 Olanzapine Thumb


20 predicted interactions (drugs) of input target (DRD5): D(1B) dopamine receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB00363 Clozapine Thumb 94.5%
2 Approved SmallMoleculeDrug DB06216 Asenapine Thumb 93.3%
3 Approved;
Investigational		 SmallMoleculeDrug DB00734 Risperidone Thumb 91.5%
4 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb 90.0%
5 Approved SmallMoleculeDrug DB04946 Iloperidone Thumb 88.3%
6 Approved;
Investigational		 SmallMoleculeDrug DB01142 Doxepin Thumb 85.7%
7 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB01239 Chlorprothixene Thumb 84.9%
8 Approved SmallMoleculeDrug DB01622 Thioproperazine Thumb 83.4%
9 Approved SmallMoleculeDrug DB00805 Minaprine Thumb 83.1%
10 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb 83.0%
11 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb 82.8%
12 Approved SmallMoleculeDrug DB01267 Paliperidone Thumb 82.6%
13 Approved;
Vet approved		 SmallMoleculeDrug DB00420 Promazine Thumb 82.2%
14 Approved;
Investigational		 SmallMoleculeDrug DB09286 Pipamperone Thumb 80.6%
15 Approved SmallMoleculeDrug DB00777 Propiomazine Thumb 80.5%
16 Approved;
Investigational		 SmallMoleculeDrug DB13025 Tiapride Thumb 80.4%
17 Approved SmallMoleculeDrug DB11273 Dihydroergocornine Thumb 79.5%
18 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB06144 Sertindole Thumb 79.3%
19 Approved;
Investigational		 SmallMoleculeDrug DB00934 Maprotiline Thumb 79.2%
20 Approved;
Investigational		 SmallMoleculeDrug DB08815 Lurasidone Thumb 79.2%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.