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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P36544
No. Gene UniProt ID Protein Name Pathway PDB
1 CHRNA7 P36544 Neuronal acetylcholine receptor subunit alpha-7 NA 2MAW; 5AFH; 5AFJ; 5AFK; 5AFL; 5AFM; 5AFN


37 known interactions (drugs) of input target (CHRNA7): Neuronal acetylcholine receptor subunit alpha-7
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved SmallMoleculeDrug DB00514 Dextromethorphan Thumb
2 Experimental;
Illicit		 SmallMoleculeDrug DB01496 Barbituric acid derivative Thumb
3 Approved;
Illicit		 SmallMoleculeDrug DB01352 Aprobarbital Thumb
4 Withdrawn SmallMoleculeDrug DB00463 Metharbital Thumb
5 Approved SmallMoleculeDrug DB01355 Hexobarbital Thumb
6 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00312 Pentobarbital Thumb
7 Approved;
Nutraceutical		 SmallMoleculeDrug DB00122 Choline Thumb
8 Approved SmallMoleculeDrug DB00898 Ethanol Thumb
9 Investigational SmallMoleculeDrug DB05137 Lobeline Thumb
10 Approved SmallMoleculeDrug DB00184 Nicotine Thumb
11 Approved;
Illicit		 SmallMoleculeDrug DB00237 Butabarbital Thumb
12 Experimental;
Investigational		 BiotechDrug DB14009 Medical Cannabis Thumb
13 Approved;
Investigational		 SmallMoleculeDrug DB00657 Mecamylamine Thumb
14 Investigational SmallMoleculeDrug DB11726 Encenicline Thumb
15 Approved;
Illicit		 SmallMoleculeDrug DB01351 Amobarbital Thumb
16 Approved SmallMoleculeDrug DB00915 Amantadine Thumb
17 Approved;
Illicit		 SmallMoleculeDrug DB00241 Butalbital Thumb
18 Approved;
Vet approved		 SmallMoleculeDrug DB00418 Secobarbital Thumb
19 Approved;
Vet approved		 SmallMoleculeDrug DB00794 Primidone Thumb
20 Approved SmallMoleculeDrug DB00849 Methylphenobarbital Thumb
21 Investigational SmallMoleculeDrug DB05708 GTS-21 Thumb
22 Approved SmallMoleculeDrug DB03128 Acetylcholine Thumb
23 Approved SmallMoleculeDrug DB01199 Tubocurarine Thumb
24 Approved SmallMoleculeDrug DB01354 Heptabarbital Thumb
25 Approved SmallMoleculeDrug DB00674 Galantamine Thumb
26 Approved;
Vet approved		 SmallMoleculeDrug DB00599 Thiopental Thumb
27 Approved;
Investigational		 SmallMoleculeDrug DB14011 Nabiximols Thumb
28 Approved;
Nutraceutical		 SmallMoleculeDrug DB14006 Choline salicylate Thumb
29 Approved;
Investigational		 SmallMoleculeDrug DB09061 Cannabidiol Thumb
30 Approved;
Investigational		 SmallMoleculeDrug DB09028 Cytisine Thumb
31 Experimental SmallMoleculeDrug DB07720 Epibatidine Thumb
32 Approved;
Illicit		 SmallMoleculeDrug DB01353 Butethal Thumb
33 Approved;
Investigational		 SmallMoleculeDrug DB01273 Varenicline Thumb
34 Approved;
Investigational		 SmallMoleculeDrug DB01174 Phenobarbital Thumb
35 Illicit SmallMoleculeDrug DB01483 Barbital Thumb
36 Investigational SmallMoleculeDrug DB05740 RPI-78M Thumb
37 Approved;
Illicit		 SmallMoleculeDrug DB00306 Talbutal Thumb


20 predicted interactions (drugs) of input target (CHRNA7): Neuronal acetylcholine receptor subunit alpha-7
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Vet approved		 SmallMoleculeDrug DB00753 Isoflurane Thumb 71.7%
2 Approved;
Nutraceutical		 SmallMoleculeDrug DB01956 Taurine Thumb 67.4%
3 Approved;
Vet approved		 SmallMoleculeDrug DB00572 Atropine Thumb 63.6%
4 Approved;
Investigational		 SmallMoleculeDrug DB00981 Physostigmine Thumb 62.8%
5 Approved;
Investigational		 SmallMoleculeDrug DB00659 Acamprosate Thumb 62.0%
6 Approved;
Investigational		 SmallMoleculeDrug DB00747 Scopolamine Thumb 61.3%
7 Approved SmallMoleculeDrug DB01245 Decamethonium Thumb 61.1%
8 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB01708 Prasterone Thumb 60.0%
9 Investigational SmallMoleculeDrug DB05458 Pozanicline Thumb 59.4%
10 Approved;
Illicit		 SmallMoleculeDrug DB00371 Meprobamate Thumb 58.8%
11 Approved;
Vet approved		 SmallMoleculeDrug DB01236 Sevoflurane Thumb 57.9%
12 Investigational SmallMoleculeDrug DB06579 Adipiplon Thumb 57.6%
13 Experimental SmallMoleculeDrug DB00466 Picrotoxin Thumb 57.0%
14 Approved;
Investigational		 SmallMoleculeDrug DB00334 Olanzapine Thumb 56.9%
15 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb 56.7%
16 Approved;
Investigational		 SmallMoleculeDrug DB00402 Eszopiclone Thumb 56.6%
17 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00228 Enflurane Thumb 56.4%
18 Approved SmallMoleculeDrug DB01205 Flumazenil Thumb 56.3%
19 Approved;
Illicit		 SmallMoleculeDrug DB01544 Flunitrazepam Thumb 56.0%
20 Investigational SmallMoleculeDrug DB05087 Ganaxolone Thumb 55.9%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.