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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P20309
No. Gene UniProt ID Protein Name Pathway PDB
1 CHRM3 P20309 Muscarinic acetylcholine receptor M3 hsa04020; hsa04080; hsa04725; hsa04742; hsa04810; hsa04911; hsa04970; hsa04971; hsa04972 2CSA


84 known interactions (drugs) of input target (CHRM3): Muscarinic acetylcholine receptor M3
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved SmallMoleculeDrug DB00185 Cevimeline Thumb
2 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb
3 Approved SmallMoleculeDrug DB04843 Mepenzolate Thumb
4 Approved;
Vet approved		 SmallMoleculeDrug DB01221 Ketamine Thumb
5 Approved SmallMoleculeDrug DB01591 Solifenacin Thumb
6 Investigational SmallMoleculeDrug DB04924 Itopride Thumb
7 Approved SmallMoleculeDrug DB00408 Loxapine Thumb
8 Approved SmallMoleculeDrug DB00725 Homatropine Methylbromide Thumb
9 Approved;
Investigational		 SmallMoleculeDrug DB00622 Nicardipine Thumb
10 Approved SmallMoleculeDrug DB00383 Oxyphencyclimine Thumb
11 Approved SmallMoleculeDrug DB00280 Disopyramide Thumb
12 Approved;
Withdrawn		 SmallMoleculeDrug DB00342 Terfenadine Thumb
13 Approved;
Investigational		 SmallMoleculeDrug DB00809 Tropicamide Thumb
14 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB01239 Chlorprothixene Thumb
15 Approved SmallMoleculeDrug DB01224 Quetiapine Thumb
16 Approved SmallMoleculeDrug DB00785 Cryptenamine Thumb
17 Approved SmallMoleculeDrug DB00376 Trihexyphenidyl Thumb
18 Approved SmallMoleculeDrug DB00517 Anisotropine Methylbromide Thumb
19 Approved SmallMoleculeDrug DB06153 Pizotifen Thumb
20 Investigational SmallMoleculeDrug DB05752 ALKS 27 Thumb
21 Approved SmallMoleculeDrug DB03128 Acetylcholine Thumb
22 Approved SmallMoleculeDrug DB00387 Procyclidine Thumb
23 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB01231 Diphenidol Thumb
24 Approved SmallMoleculeDrug DB01019 Bethanechol Thumb
25 Approved SmallMoleculeDrug DB00363 Clozapine Thumb
26 Approved SmallMoleculeDrug DB01226 Mivacurium Thumb
27 Approved SmallMoleculeDrug DB09076 Umeclidinium Thumb
28 Approved SmallMoleculeDrug DB11235 Thonzylamine Thumb
29 Approved SmallMoleculeDrug DB06787 Hexocyclium Thumb
30 Approved;
Investigational		 SmallMoleculeDrug DB00747 Scopolamine Thumb
31 Approved SmallMoleculeDrug DB00202 Succinylcholine Thumb
32 Withdrawn SmallMoleculeDrug DB00505 Tridihexethyl Thumb
33 Approved;
Investigational		 SmallMoleculeDrug DB00934 Maprotiline Thumb
34 Approved SmallMoleculeDrug DB01338 Pipecuronium Thumb
35 Approved;
Investigational		 SmallMoleculeDrug DB01062 Oxybutynin Thumb
36 Withdrawn SmallMoleculeDrug DB00767 Benzquinamide Thumb
37 Approved SmallMoleculeDrug DB06702 Fesoterodine Thumb
38 Approved;
Vet approved		 SmallMoleculeDrug DB01625 Isopropamide Thumb
39 Approved SmallMoleculeDrug DB00411 Carbachol Thumb
40 Approved;
Investigational		 SmallMoleculeDrug DB00496 Darifenacin Thumb
41 Approved;
Investigational		 SmallMoleculeDrug DB01238 Aripiprazole Thumb
42 Approved SmallMoleculeDrug DB00462 Methylscopolamine bromide Thumb
43 Approved SmallMoleculeDrug DB11181 Homatropine Thumb
44 Approved;
Investigational		 SmallMoleculeDrug DB06709 Methacholine Thumb
45 Approved SmallMoleculeDrug DB01409 Tiotropium Thumb
46 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB09300 Butylscopolamine Thumb
47 Experimental SmallMoleculeDrug DB04365 Arecoline Thumb
48 Approved;
Investigational		 SmallMoleculeDrug DB00193 Tramadol Thumb
49 Approved;
Investigational		 SmallMoleculeDrug DB01151 Desipramine Thumb
50 Approved SmallMoleculeDrug DB00332 Ipratropium Thumb
51 Approved SmallMoleculeDrug DB00458 Imipramine Thumb
52 Approved;
Investigational		 SmallMoleculeDrug DB12278 Propiverine Thumb
53 Approved;
Investigational		 SmallMoleculeDrug DB00555 Lamotrigine Thumb
54 Approved;
Vet approved		 SmallMoleculeDrug DB00599 Thiopental Thumb
55 Approved;
Investigational		 SmallMoleculeDrug DB01036 Tolterodine Thumb
56 Approved SmallMoleculeDrug DB00454 Pethidine Thumb
57 Approved;
Vet approved		 SmallMoleculeDrug DB00572 Atropine Thumb
58 Approved SmallMoleculeDrug DB00424 Hyoscyamine Thumb
59 Approved SmallMoleculeDrug DB00835 Brompheniramine Thumb
60 Approved;
Investigational		 SmallMoleculeDrug DB14185 Aripiprazole lauroxil Thumb
61 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb
62 Approved;
Vet approved		 SmallMoleculeDrug DB00420 Promazine Thumb
63 Approved;
Investigational		 SmallMoleculeDrug DB01069 Promethazine Thumb
64 Approved SmallMoleculeDrug DB09167 Dosulepin Thumb
65 Approved SmallMoleculeDrug DB01337 Pancuronium Thumb
66 Approved;
Investigational		 SmallMoleculeDrug DB09262 Imidafenacin Thumb
67 Approved SmallMoleculeDrug DB00340 Metixene Thumb
68 Approved SmallMoleculeDrug DB08897 Aclidinium Thumb
69 Approved;
Investigational		 SmallMoleculeDrug DB00715 Paroxetine Thumb
70 Approved SmallMoleculeDrug DB00246 Ziprasidone Thumb
71 Approved;
Investigational		 SmallMoleculeDrug DB01142 Doxepin Thumb
72 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb
73 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00477 Chlorpromazine Thumb
74 Approved SmallMoleculeDrug DB09089 Trimebutine Thumb
75 Approved SmallMoleculeDrug DB00434 Cyproheptadine Thumb
76 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00986 Glycopyrronium Thumb
77 Approved;
Vet approved;
Withdrawn		 SmallMoleculeDrug DB00729 Diphemanil Methylsulfate Thumb
78 Approved;
Investigational		 SmallMoleculeDrug DB00568 Cinnarizine Thumb
79 Approved;
Investigational		 SmallMoleculeDrug DB01403 Methotrimeprazine Thumb
80 Approved;
Investigational		 SmallMoleculeDrug DB00334 Olanzapine Thumb
81 Approved SmallMoleculeDrug DB00777 Propiomazine Thumb
82 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb
83 Withdrawn SmallMoleculeDrug DB09194 Etoperidone Thumb
84 Approved;
Investigational		 SmallMoleculeDrug DB01085 Pilocarpine Thumb


20 predicted interactions (drugs) of input target (CHRM3): Muscarinic acetylcholine receptor M3
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB00392 Ethopropazine Thumb 87.4%
2 Approved SmallMoleculeDrug DB00804 Dicyclomine Thumb 86.8%
3 Approved;
Vet approved		 SmallMoleculeDrug DB00508 Triflupromazine Thumb 86.1%
4 Approved;
Investigational		 SmallMoleculeDrug DB08801 Dimetindene Thumb 85.5%
5 Approved;
Illicit		 SmallMoleculeDrug DB00907 Cocaine Thumb 85.2%
6 Approved SmallMoleculeDrug DB00483 Gallamine Triethiodide Thumb 83.7%
7 Approved SmallMoleculeDrug DB01148 Flavoxate Thumb 83.6%
8 Withdrawn SmallMoleculeDrug DB04834 Rapacuronium Thumb 82.6%
9 Approved;
Investigational		 SmallMoleculeDrug DB01075 Diphenhydramine Thumb 81.9%
10 Approved SmallMoleculeDrug DB00354 Buclizine Thumb 80.3%
11 Approved SmallMoleculeDrug DB00215 Citalopram Thumb 80.0%
12 Approved SmallMoleculeDrug DB00728 Rocuronium Thumb 79.1%
13 Approved SmallMoleculeDrug DB01618 Molindone Thumb 78.4%
14 Approved SmallMoleculeDrug DB00805 Minaprine Thumb 78.4%
15 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB00875 Flupentixol Thumb 78.3%
16 Approved SmallMoleculeDrug DB01135 Doxacurium chloride Thumb 77.9%
17 Approved SmallMoleculeDrug DB00245 Benzatropine Thumb 77.5%
18 Approved;
Investigational		 SmallMoleculeDrug DB01175 Escitalopram Thumb 76.8%
19 Approved SmallMoleculeDrug DB01336 Metocurine Thumb 76.3%
20 Investigational SmallMoleculeDrug DB05766 ACP-104 Thumb 75.6%


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.