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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P13945
No. Gene UniProt ID Protein Name Pathway PDB
1 ADRB3 P13945 Beta-3 adrenergic receptor hsa04020; hsa04022; hsa04080; hsa04714; hsa04923; hsa04924; hsa04970 2CDW


35 known interactions (drugs) of input target (ADRB3): Beta-3 adrenergic receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational		 SmallMoleculeDrug DB00571 Propranolol Thumb
2 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb
3 Approved;
Withdrawn		 SmallMoleculeDrug DB00866 Alprenolol Thumb
4 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01407 Clenbuterol Thumb
5 Approved;
Vet approved		 SmallMoleculeDrug DB00668 Epinephrine Thumb
6 Approved SmallMoleculeDrug DB08893 Mirabegron Thumb
7 Approved SmallMoleculeDrug DB00368 Norepinephrine Thumb
8 Approved;
Investigational		 SmallMoleculeDrug DB04846 Celiprolol Thumb
9 Approved;
Experimental		 SmallMoleculeDrug DB13345 Dihydroergocristine Thumb
10 Investigational SmallMoleculeDrug DB05395 Amibegron Thumb
11 Approved SmallMoleculeDrug DB01580 Oxprenolol Thumb
12 Approved;
Investigational		 SmallMoleculeDrug DB01288 Fenoterol Thumb
13 Approved SmallMoleculeDrug DB08807 Bopindolol Thumb
14 Approved SmallMoleculeDrug DB01365 Mephentermine Thumb
15 Approved SmallMoleculeDrug DB01102 Arbutamine Thumb
16 Experimental;
Investigational		 SmallMoleculeDrug DB06726 Bufuralol Thumb
17 Approved SmallMoleculeDrug DB08808 Bupranolol Thumb
18 Approved SmallMoleculeDrug DB00871 Terbutaline Thumb
19 Approved SmallMoleculeDrug DB11124 Racepinephrine Thumb
20 Approved;
Investigational		 SmallMoleculeDrug DB00960 Pindolol Thumb
21 Investigational SmallMoleculeDrug DB06190 Solabegron Thumb
22 Approved;
Vet approved		 SmallMoleculeDrug DB01001 Salbutamol Thumb
23 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb
24 Approved SmallMoleculeDrug DB00217 Bethanidine Thumb
25 Approved;
Investigational		 SmallMoleculeDrug DB01064 Isoprenaline Thumb
26 Approved;
Investigational		 SmallMoleculeDrug DB00983 Formoterol Thumb
27 Approved SmallMoleculeDrug DB11273 Dihydroergocornine Thumb
28 Approved SmallMoleculeDrug DB00938 Salmeterol Thumb
29 Approved SmallMoleculeDrug DB01049 Ergoloid mesylate Thumb
30 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB00182 Amphetamine Thumb
31 Approved;
Nutraceutical;
Withdrawn		 SmallMoleculeDrug DB01363 Ephedra Thumb
32 Approved SmallMoleculeDrug DB11278 DL-Methylephedrine Thumb
33 Approved;
Investigational		 SmallMoleculeDrug DB00334 Olanzapine Thumb
34 Approved;
Investigational		 SmallMoleculeDrug DB06262 Droxidopa Thumb
35 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb


20 predicted interactions (drugs) of input target (ADRB3): Beta-3 adrenergic receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB00408 Loxapine Thumb 82.7%
2 Approved SmallMoleculeDrug DB00248 Cabergoline Thumb 81.3%
3 Approved SmallMoleculeDrug DB00841 Dobutamine Thumb 78.7%
4 Approved SmallMoleculeDrug DB06216 Asenapine Thumb 76.5%
5 Approved SmallMoleculeDrug DB00370 Mirtazapine Thumb 76.4%
6 Approved SmallMoleculeDrug DB00449 Dipivefrin Thumb 75.8%
7 Approved;
Investigational		 SmallMoleculeDrug DB00555 Lamotrigine Thumb 75.4%
8 Approved;
Vet approved;
Withdrawn		 SmallMoleculeDrug DB00397 Phenylpropanolamine Thumb 74.0%
9 Approved;
Investigational		 SmallMoleculeDrug DB01151 Desipramine Thumb 72.8%
10 Approved SmallMoleculeDrug DB00925 Phenoxybenzamine Thumb 72.0%
11 Approved SmallMoleculeDrug DB00598 Labetalol Thumb 70.6%
12 Approved SmallMoleculeDrug DB01295 Bevantolol Thumb 69.9%
13 Approved SmallMoleculeDrug DB04855 Dronedarone Thumb 69.0%
14 Investigational SmallMoleculeDrug DB09204 Arotinolol Thumb 68.7%
15 Approved SmallMoleculeDrug DB00988 Dopamine Thumb 68.6%
16 Approved SmallMoleculeDrug DB00852 Pseudoephedrine Thumb 68.5%
17 Approved;
Investigational		 SmallMoleculeDrug DB01142 Doxepin Thumb 68.1%
18 Approved;
Investigational		 SmallMoleculeDrug DB09068 Vortioxetine Thumb 67.7%
19 Approved;
Illicit		 SmallMoleculeDrug DB01577 Methamphetamine Thumb 67.2%
20 Approved;
Investigational		 SmallMoleculeDrug DB01359 Penbutolol Thumb 67.0%


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.