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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q01959
No. Gene UniProt ID Protein Name Pathway PDB
1 SLC6A3 Q01959 Sodium-dependent dopamine transporter hsa04728; hsa05012; hsa05030; hsa05031; hsa05034 NA


47 known interactions (drugs) of input target (SLC6A3): Sodium-dependent dopamine transporter
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational		 SmallMoleculeDrug DB00422 Methylphenidate Thumb
2 Approved;
Illicit		 SmallMoleculeDrug DB00191 Phentermine Thumb
3 Approved SmallMoleculeDrug DB00408 Loxapine Thumb
4 Approved;
Illicit		 SmallMoleculeDrug DB00937 Diethylpropion Thumb
5 Approved SmallMoleculeDrug DB00476 Duloxetine Thumb
6 Investigational SmallMoleculeDrug DB04947 Altropane Thumb
7 Approved;
Illicit		 SmallMoleculeDrug DB01576 Dextroamphetamine Thumb
8 Approved;
Investigational		 SmallMoleculeDrug DB01175 Escitalopram Thumb
9 Approved;
Withdrawn		 SmallMoleculeDrug DB01149 Nefazodone Thumb
10 Approved;
Investigational		 SmallMoleculeDrug DB06148 Mianserin Thumb
11 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00721 Procaine Thumb
12 Approved SmallMoleculeDrug DB00458 Imipramine Thumb
13 Approved SmallMoleculeDrug DB00454 Pethidine Thumb
14 Approved SmallMoleculeDrug DB00988 Dopamine Thumb
15 Approved;
Illicit		 SmallMoleculeDrug DB00830 Phenmetrazine Thumb
16 Investigational SmallMoleculeDrug DB06156 Tesofensine Thumb
17 Approved;
Illicit		 SmallMoleculeDrug DB00865 Benzphetamine Thumb
18 Approved SmallMoleculeDrug DB00289 Atomoxetine Thumb
19 Approved;
Investigational		 SmallMoleculeDrug DB00745 Modafinil Thumb
20 Approved SmallMoleculeDrug DB00852 Pseudoephedrine Thumb
21 Approved SmallMoleculeDrug DB01156 Bupropion Thumb
22 Approved;
Illicit		 SmallMoleculeDrug DB00907 Cocaine Thumb
23 Approved SmallMoleculeDrug DB01114 Chlorphenamine Thumb
24 Investigational BiotechDrug DB06333 Trodusquemine Thumb
25 Approved;
Illicit;
Withdrawn		 SmallMoleculeDrug DB01463 Fencamfamine Thumb
26 Approved;
Investigational		 SmallMoleculeDrug DB00579 Mazindol Thumb
27 Approved SmallMoleculeDrug DB00245 Benzatropine Thumb
28 Approved;
Illicit;
Investigational;
Withdrawn		 SmallMoleculeDrug DB01105 Sibutramine Thumb
29 Approved SmallMoleculeDrug DB00285 Venlafaxine Thumb
30 Withdrawn SmallMoleculeDrug DB04821 Nomifensine Thumb
31 Approved;
Investigational		 SmallMoleculeDrug DB06701 Dexmethylphenidate Thumb
32 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb
33 Experimental;
Illicit		 SmallMoleculeDrug DB01442 MMDA Thumb
34 Investigational SmallMoleculeDrug DB03701 Vanoxerine Thumb
35 Approved SmallMoleculeDrug DB01161 Chloroprocaine Thumb
36 Approved;
Investigational		 SmallMoleculeDrug DB06413 Armodafinil Thumb
37 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb
38 Experimental;
Illicit		 SmallMoleculeDrug DB01472 4-Methoxyamphetamine Thumb
39 Experimental;
Illicit;
Investigational		 SmallMoleculeDrug DB01454 Midomafetamine Thumb
40 Approved;
Investigational		 SmallMoleculeDrug DB01146 Diphenylpyraline Thumb
41 Approved SmallMoleculeDrug DB00370 Mirtazapine Thumb
42 Approved SmallMoleculeDrug DB01104 Sertraline Thumb
43 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB00182 Amphetamine Thumb
44 Approved;
Nutraceutical;
Withdrawn		 SmallMoleculeDrug DB01363 Ephedra Thumb
45 Approved;
Illicit		 SmallMoleculeDrug DB01577 Methamphetamine Thumb
46 Approved;
Investigational		 SmallMoleculeDrug DB01255 Lisdexamfetamine Thumb
47 Investigational SmallMoleculeDrug DB12305 Dasotraline Thumb


20 predicted interactions (drugs) of input target (SLC6A3): Sodium-dependent dopamine transporter
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb 88.4%
2 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb 83.4%
3 Approved;
Vet approved		 SmallMoleculeDrug DB01221 Ketamine Thumb 82.6%
4 Approved;
Investigational		 SmallMoleculeDrug DB01142 Doxepin Thumb 81.1%
5 Approved SmallMoleculeDrug DB00661 Verapamil Thumb 79.6%
6 Approved SmallMoleculeDrug DB09167 Dosulepin Thumb 79.5%
7 Approved;
Investigational		 SmallMoleculeDrug DB00656 Trazodone Thumb 78.0%
8 Approved;
Investigational		 SmallMoleculeDrug DB00555 Lamotrigine Thumb 76.8%
9 Investigational;
Nutraceutical		 SmallMoleculeDrug DB08839 Serotonin Thumb 76.4%
10 Approved;
Investigational		 SmallMoleculeDrug DB01151 Desipramine Thumb 75.8%
11 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01242 Clomipramine Thumb 74.4%
12 Approved;
Investigational		 SmallMoleculeDrug DB00934 Maprotiline Thumb 72.7%
13 Approved SmallMoleculeDrug DB00215 Citalopram Thumb 72.7%
14 Approved SmallMoleculeDrug DB00696 Ergotamine Thumb 72.3%
15 Investigational SmallMoleculeDrug DB05964 Amitifadine Thumb 72.0%
16 Approved SmallMoleculeDrug DB00805 Minaprine Thumb 71.2%
17 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB09225 Zotepine Thumb 70.5%
18 Approved;
Investigational		 SmallMoleculeDrug DB09068 Vortioxetine Thumb 69.8%
19 Approved SmallMoleculeDrug DB01364 Ephedrine Thumb 69.6%
20 Investigational SmallMoleculeDrug DB04889 Bicifadine Thumb 69.5%


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.