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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q15822
No. Gene UniProt ID Protein Name Pathway PDB
1 CHRNA2 Q15822 Neuronal acetylcholine receptor subunit alpha-2 hsa04080 NA


25 known interactions (drugs) of input target (CHRNA2): Neuronal acetylcholine receptor subunit alpha-2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved SmallMoleculeDrug DB00514 Dextromethorphan Thumb
2 Approved;
Withdrawn		 SmallMoleculeDrug DB00416 Metocurine Iodide Thumb
3 Approved SmallMoleculeDrug DB01336 Metocurine Thumb
4 Approved SmallMoleculeDrug DB01135 Doxacurium chloride Thumb
5 Approved SmallMoleculeDrug DB00565 Cisatracurium Thumb
6 Approved SmallMoleculeDrug DB00728 Rocuronium Thumb
7 Approved SmallMoleculeDrug DB01339 Vecuronium Thumb
8 Approved SmallMoleculeDrug DB00732 Atracurium besylate Thumb
9 Approved SmallMoleculeDrug DB00898 Ethanol Thumb
10 Approved SmallMoleculeDrug DB00184 Nicotine Thumb
11 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00721 Procaine Thumb
12 Approved;
Vet approved		 SmallMoleculeDrug DB00472 Fluoxetine Thumb
13 Approved SmallMoleculeDrug DB01338 Pipecuronium Thumb
14 Approved SmallMoleculeDrug DB00411 Carbachol Thumb
15 Approved SmallMoleculeDrug DB01199 Tubocurarine Thumb
16 Approved SmallMoleculeDrug DB01226 Mivacurium Thumb
17 Approved SmallMoleculeDrug DB00674 Galantamine Thumb
18 Approved SmallMoleculeDrug DB00483 Gallamine Triethiodide Thumb
19 Approved SmallMoleculeDrug DB01245 Decamethonium Thumb
20 Experimental SmallMoleculeDrug DB08960 Hexamethonium Thumb
21 Approved SmallMoleculeDrug DB01337 Pancuronium Thumb
22 Experimental SmallMoleculeDrug DB07720 Epibatidine Thumb
23 Approved;
Investigational		 SmallMoleculeDrug DB00810 Biperiden Thumb
24 Approved;
Investigational		 SmallMoleculeDrug DB00657 Mecamylamine Thumb
25 Investigational SmallMoleculeDrug DB05740 RPI-78M Thumb


20 predicted interactions (drugs) of input target (CHRNA2): Neuronal acetylcholine receptor subunit alpha-2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 SmallMoleculeDrug DB00747 Scopolamine Thumb 59.7%
2 Approved;
Vet approved		 SmallMoleculeDrug DB00572 Atropine Thumb 55.1%
3 Approved;
Investigational		 SmallMoleculeDrug DB00981 Physostigmine Thumb 52.8%
4 Approved SmallMoleculeDrug DB03128 Acetylcholine Thumb 52.5%
5 Approved SmallMoleculeDrug DB00915 Amantadine Thumb 50.9%
6 Approved SmallMoleculeDrug DB01090 Pentolinium Thumb 50.4%
7 Approved SmallMoleculeDrug DB09089 Trimebutine Thumb 48.3%
8 Approved;
Investigational		 SmallMoleculeDrug DB01273 Varenicline Thumb 46.1%
9 Investigational SmallMoleculeDrug DB05137 Lobeline Thumb 44.7%
10 Approved SmallMoleculeDrug DB00202 Succinylcholine Thumb 42.5%
11 Approved;
Investigational		 SmallMoleculeDrug DB01227 Levomethadyl Acetate Thumb 42.3%
12 Approved SmallMoleculeDrug DB00458 Imipramine Thumb 41.4%
13 Approved;
Investigational		 SmallMoleculeDrug DB09028 Cytisine Thumb 41.1%
14 Approved SmallMoleculeDrug DB01161 Chloroprocaine Thumb 40.2%
15 Approved;
Illicit		 SmallMoleculeDrug DB00907 Cocaine Thumb 39.5%
16 Approved SmallMoleculeDrug DB00392 Ethopropazine Thumb 38.5%
17 Approved;
Vet approved		 SmallMoleculeDrug DB00753 Isoflurane Thumb 38.4%
18 Approved;
Withdrawn		 SmallMoleculeDrug DB00342 Terfenadine Thumb 38.4%
19 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB13956 Estradiol valerate Thumb 38.4%
20 Investigational SmallMoleculeDrug DB05855 Rivanicline Thumb 36.9%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.