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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P04150
No. Gene UniProt ID Protein Name Pathway PDB
1 NR3C1 P04150 Glucocorticoid receptor hsa04080 1M2Z; 1NHZ; 1P93; 3BQD; 3CLD; 3E7C; 3H52; 3K22; 3K23; 4CSJ; 4HN5; 4HN6; 4LSJ; 4MDD; 4P6W; 4P6X


51 known interactions (drugs) of input target (NR3C1): Glucocorticoid receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Vet approved		 SmallMoleculeDrug DB00663 Flumethasone Thumb
2 Approved SmallMoleculeDrug DB00421 Spironolactone Thumb
3 Approved;
Vet approved		 SmallMoleculeDrug DB00635 Prednisone Thumb
4 Approved;
Investigational		 SmallMoleculeDrug DB00394 Beclomethasone dipropionate Thumb
5 Approved;
Illicit		 SmallMoleculeDrug DB01185 Fluoxymesterone Thumb
6 Approved;
Investigational		 SmallMoleculeDrug DB00324 Fluorometholone Thumb
7 Approved SmallMoleculeDrug DB00596 Ulobetasol Thumb
8 Approved;
Investigational		 SmallMoleculeDrug DB01410 Ciclesonide Thumb
9 Approved;
Investigational		 SmallMoleculeDrug DB01380 Cortisone acetate Thumb
10 Approved SmallMoleculeDrug DB00846 Flurandrenolide Thumb
11 Investigational SmallMoleculeDrug DB12637 Onapristone Thumb
12 Approved;
Withdrawn		 SmallMoleculeDrug DB09091 Tixocortol Thumb
13 Approved SmallMoleculeDrug DB00288 Amcinonide Thumb
14 Approved SmallMoleculeDrug DB01384 Paramethasone Thumb
15 Approved SmallMoleculeDrug DB00588 Fluticasone propionate Thumb
16 Approved SmallMoleculeDrug DB00223 Diflorasone Thumb
17 Approved SmallMoleculeDrug DB11619 Gestrinone Thumb
18 Approved SmallMoleculeDrug DB00838 Clocortolone Thumb
19 Approved SmallMoleculeDrug DB13158 Clobetasone Thumb
20 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00591 Fluocinolone Acetonide Thumb
21 Approved SmallMoleculeDrug DB00769 Hydrocortamate Thumb
22 Approved;
Vet approved		 SmallMoleculeDrug DB00741 Hydrocortisone Thumb
23 Approved;
Investigational		 SmallMoleculeDrug DB00687 Fludrocortisone Thumb
24 Approved SmallMoleculeDrug DB06781 Difluprednate Thumb
25 Approved;
Investigational		 SmallMoleculeDrug DB01047 Fluocinonide Thumb
26 Approved;
Vet approved		 SmallMoleculeDrug DB00620 Triamcinolone Thumb
27 Approved;
Investigational		 SmallMoleculeDrug DB00180 Flunisolide Thumb
28 Approved;
Vet approved		 SmallMoleculeDrug DB00396 Progesterone Thumb
29 Approved;
Investigational		 SmallMoleculeDrug DB01130 Prednicarbate Thumb
30 Approved SmallMoleculeDrug DB01013 Clobetasol propionate Thumb
31 Approved SmallMoleculeDrug DB00240 Alclometasone Thumb
32 Approved;
Investigational		 SmallMoleculeDrug DB00834 Mifepristone Thumb
33 Experimental SmallMoleculeDrug DB02210 Hexane-1,6-Diol Thumb
34 Approved SmallMoleculeDrug DB00253 Medrysone Thumb
35 Approved SmallMoleculeDrug DB01222 Budesonide Thumb
36 Approved;
Vet approved		 SmallMoleculeDrug DB00764 Mometasone Thumb
37 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00351 Megestrol acetate Thumb
38 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB09095 Difluocortolone Thumb
39 Approved SmallMoleculeDrug DB00896 Rimexolone Thumb
40 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01234 Dexamethasone Thumb
41 Approved SmallMoleculeDrug DB08867 Ulipristal Thumb
42 Approved SmallMoleculeDrug DB08906 Fluticasone furoate Thumb
43 Approved SmallMoleculeDrug DB00547 Desoximetasone Thumb
44 Experimental;
Investigational		 SmallMoleculeDrug DB04630 Aldosterone Thumb
45 Approved SmallMoleculeDrug DB00873 Loteprednol Thumb
46 Investigational SmallMoleculeDrug DB13003 Cortivazol Thumb
47 Investigational SmallMoleculeDrug DB05423 ORG-34517 Thumb
48 Approved;
Investigational		 SmallMoleculeDrug DB01260 Desonide Thumb
49 Approved;
Vet approved		 SmallMoleculeDrug DB00959 Methylprednisolone Thumb
50 Approved;
Vet approved		 SmallMoleculeDrug DB00860 Prednisolone Thumb
51 Approved;
Vet approved		 SmallMoleculeDrug DB00443 Betamethasone Thumb


20 predicted interactions (drugs) of input target (NR3C1): Glucocorticoid receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB00898 Ethanol Thumb 41.7%
2 Experimental SmallMoleculeDrug DB03467 Naringenin Thumb 37.4%
3 Experimental SmallMoleculeDrug DB03565 1-O-Octyl-2-Heptylphosphonyl-Sn-Glycero-3-Phosphoethanolamine Thumb 36.3%
4 Approved SmallMoleculeDrug DB01395 Drospirenone Thumb 34.8%
5 Experimental;
Investigational		 SmallMoleculeDrug DB02938 Heptanoic Acid Thumb 34.2%
6 Approved;
Nutraceutical		 SmallMoleculeDrug DB00138 Cystine Thumb 34.1%
7 Approved SmallMoleculeDrug DB00648 Mitotane Thumb 33.6%
8 Approved;
Vet approved		 SmallMoleculeDrug DB01159 Halothane Thumb 32.5%
9 Experimental SmallMoleculeDrug DB04447 1,4-Dithiothreitol Thumb 32.2%
10 Approved;
Investigational		 SmallMoleculeDrug DB00393 Nimodipine Thumb 31.4%
11 Experimental SmallMoleculeDrug DB08342 S-PALMITOYL-L-CYSTEINE Thumb 31.4%
12 Approved;
Withdrawn		 SmallMoleculeDrug DB00431 Lindane Thumb 30.9%
13 Experimental SmallMoleculeDrug DB08515 (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Thumb 30.2%
14 Experimental SmallMoleculeDrug DB01840 2-Deoxy-D-Glucitol 6-(E)-Vinylhomophosphonate Thumb 29.8%
15 Withdrawn SmallMoleculeDrug DB04821 Nomifensine Thumb 29.4%
16 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB13954 Estradiol cypionate Thumb 28.8%
17 Approved SmallMoleculeDrug DB02659 Cholic Acid Thumb 28.8%
18 Approved;
Investigational		 SmallMoleculeDrug DB01064 Isoprenaline Thumb 28.2%
19 Approved;
Investigational		 SmallMoleculeDrug DB02325 Isopropyl Alcohol Thumb 28.1%
20 Approved SmallMoleculeDrug DB11219 Enzacamene Thumb 27.8%


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.