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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q9UNX9
No. Gene UniProt ID Protein Name Pathway PDB
1 KCNJ14 Q9UNX9 ATP-sensitive inward rectifier potassium channel 14 hsa04725; hsa04921 NA

2 known interactions (drugs) of input target (KCNJ14): ATP-sensitive inward rectifier potassium channel 14
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Approved;
SmallMoleculeDrug DB11148 Butamben Thumb
2 Approved;
Vet approved
SmallMoleculeDrug DB01392 Yohimbine Thumb

20 predicted interactions (drugs) of input target (KCNJ14): ATP-sensitive inward rectifier potassium channel 14
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved SmallMoleculeDrug DB00661 Verapamil Thumb 33.4%
2 Approved SmallMoleculeDrug DB00421 Spironolactone Thumb 31.1%
3 Investigational;
SmallMoleculeDrug DB01388 Mibefradil Thumb 27.3%
4 Approved;
Vet approved
SmallMoleculeDrug DB01154 Thiamylal Thumb 24.9%
5 Approved SmallMoleculeDrug DB00308 Ibutilide Thumb 24.7%
6 Approved;
SmallMoleculeDrug DB13746 Bioallethrin Thumb 24.2%
7 Approved;
SmallMoleculeDrug DB00922 Levosimendan Thumb 22.9%
8 Approved;
SmallMoleculeDrug DB00568 Cinnarizine Thumb 21.6%
9 Approved;
SmallMoleculeDrug DB09238 Manidipine Thumb 21.5%
10 Approved;
SmallMoleculeDrug DB11633 Isavuconazole Thumb 21.4%
11 Approved SmallMoleculeDrug DB00381 Amlodipine Thumb 21.3%
12 Experimental;
SmallMoleculeDrug DB08838 Agmatine Thumb 21.3%
13 Approved;
SmallMoleculeDrug DB01054 Nitrendipine Thumb 21.2%
14 Approved SmallMoleculeDrug DB04855 Dronedarone Thumb 21.2%
15 Approved;
SmallMoleculeDrug DB09231 Benidipine Thumb 21.1%
16 Approved;
SmallMoleculeDrug DB09232 Cilnidipine Thumb 20.7%
17 Approved SmallMoleculeDrug DB00222 Glimepiride Thumb 20.6%
18 Approved SmallMoleculeDrug DB01016 Glyburide Thumb 20.4%
19 Approved SmallMoleculeDrug DB00825 Menthol Thumb 20.3%
20 Approved;
SmallMoleculeDrug DB09236 Lacidipine Thumb 19.9%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.