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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P37173
No. Gene UniProt ID Protein Name Pathway PDB
1 TGFBR2 P37173 TGF-beta receptor type-2 hsa04010; hsa04060; hsa04068; hsa04144; hsa04218; hsa04350; hsa04380; hsa04390; hsa04520; hsa04659; hsa04926; hsa04933; hsa05142; hsa05166; hsa05200; hsa05202; hsa05210; hsa05212; hsa05220; hsa05225; hsa05226 1KTZ; 1M9Z; 1PLO; 2PJY; 3KFD; 4P7U; 4XJJ

4 known interactions (drugs) of input target (TGFBR2): TGF-beta receptor type-2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Approved BiotechDrug DB10770 Foreskin fibroblast (neonatal) Thumb
2 Approved BiotechDrug DB10772 Foreskin keratinocyte (neonatal) Thumb
3 Approved;
SmallMoleculeDrug DB12010 Fostamatinib Thumb
4 Approved;
SmallMoleculeDrug DB09462 Glycerin Thumb

20 predicted interactions (drugs) of input target (TGFBR2): TGF-beta receptor type-2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
SmallMoleculeDrug DB01254 Dasatinib Thumb 41.0%
2 Approved SmallMoleculeDrug DB08896 Regorafenib Thumb 36.7%
3 Approved SmallMoleculeDrug DB00619 Imatinib Thumb 31.2%
4 Approved SmallMoleculeDrug DB06589 Pazopanib Thumb 30.7%
5 Investigational BiotechDrug DB05110 VIR201 Thumb 26.4%
6 Approved;
SmallMoleculeDrug DB05676 Apremilast Thumb 26.3%
7 Approved;
SmallMoleculeDrug DB01268 Sunitinib Thumb 26.1%
8 Approved SmallMoleculeDrug DB09079 Nintedanib Thumb 24.1%
9 Experimental SmallMoleculeDrug DB01901 Sucrosofate Thumb 23.7%
10 Approved;
SmallMoleculeDrug DB08901 Ponatinib Thumb 23.6%
11 Approved;
BiotechDrug DB00102 Becaplermin Thumb 23.2%
12 Approved;
SmallMoleculeDrug DB11967 Binimetinib Thumb 22.5%
13 Approved SmallMoleculeDrug DB00201 Caffeine Thumb 21.9%
14 Approved;
SmallMoleculeDrug DB12267 Brigatinib Thumb 21.1%
15 Approved;
SmallMoleculeDrug DB09221 Polaprezinc Thumb 20.9%
16 Investigational SmallMoleculeDrug DB12140 Dilmapimod Thumb 20.7%
17 Approved;
SmallMoleculeDrug DB01296 Glucosamine Thumb 20.4%
18 Approved SmallMoleculeDrug DB01250 Olsalazine Thumb 20.3%
19 Investigational SmallMoleculeDrug DB05744 CRx-139 Thumb 19.8%
20 Approved;
SmallMoleculeDrug DB09078 Lenvatinib Thumb 19.8%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.