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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: O75116
No. Gene UniProt ID Protein Name Pathway PDB
1 ROCK2 O75116 Rho-associated protein kinase 2 hsa04022; hsa04024; hsa04062; hsa04071; hsa04270; hsa04310; hsa04360; hsa04510; hsa04530; hsa04611; hsa04670; hsa04810; hsa04921; hsa05130; hsa05131; hsa05132; hsa05163; hsa05200; hsa05205 4L6Q; 4WOT

5 known interactions (drugs) of input target (ROCK2): Rho-associated protein kinase 2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Investigational SmallMoleculeDrug DB08162 Fasudil Thumb
2 Approved;
SmallMoleculeDrug DB12010 Fostamatinib Thumb
3 Approved SmallMoleculeDrug DB13165 Ripasudil Thumb
4 Approved SmallMoleculeDrug DB13931 Netarsudil Thumb
5 Experimental SmallMoleculeDrug DB08756 (R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDE Thumb

20 predicted interactions (drugs) of input target (ROCK2): Rho-associated protein kinase 2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Experimental SmallMoleculeDrug DB07876 (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE Thumb 43.5%
2 Experimental SmallMoleculeDrug DB04707 Hydroxyfasudil Thumb 38.9%
3 Approved;
SmallMoleculeDrug DB01254 Dasatinib Thumb 23.7%
4 Experimental SmallMoleculeDrug DB07859 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE Thumb 22.9%
5 Experimental SmallMoleculeDrug DB02010 Staurosporine Thumb 22.6%
6 Approved;
SmallMoleculeDrug DB01268 Sunitinib Thumb 21.9%
7 Approved BiotechDrug DB10770 Foreskin fibroblast (neonatal) Thumb 21.7%
8 Experimental SmallMoleculeDrug DB08149 1-[4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamine Thumb 21.2%
9 Approved SmallMoleculeDrug DB08916 Afatinib Thumb 20.9%
10 Experimental SmallMoleculeDrug DB07204 (1S)-1-(1H-INDOL-3-YLMETHYL)-2-(2-PYRIDIN-4-YL-[1,7]NAPHTYRIDIN-5-YLOXY)-EHYLAMINE Thumb 20.9%
11 Approved BiotechDrug DB10772 Foreskin keratinocyte (neonatal) Thumb 20.7%
12 Experimental SmallMoleculeDrug DB04522 Dexfosfoserine Thumb 20.3%
13 Experimental SmallMoleculeDrug DB07855 (S)-1-PHENYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE Thumb 19.8%
14 Experimental SmallMoleculeDrug DB08070 2-[4-(3-METHYL-1H-PYRAZOL-4-YL)PHENYL]ETHANAMINE Thumb 19.7%
15 Approved;
Vet approved
SmallMoleculeDrug DB00945 Acetylsalicylic acid Thumb 19.4%
16 Experimental SmallMoleculeDrug DB08114 5-benzyl-1,3-thiazol-2-amine Thumb 19.0%
17 Experimental SmallMoleculeDrug DB08568 (2S)-1-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}-3-PHENYLPROPAN-2-AMINE Thumb 18.9%
18 Approved SmallMoleculeDrug DB01212 Ceftriaxone Thumb 18.8%
19 Approved;
SmallMoleculeDrug DB01942 Formic Acid Thumb 18.7%
20 Investigational SmallMoleculeDrug DB12742 Amuvatinib Thumb 18.3%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.