QuartataWeb
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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q02156
No. Gene UniProt ID Protein Name Pathway PDB
1 PRKCE Q02156 Protein kinase C epsilon type hsa04022; hsa04071; hsa04270; hsa04371; hsa04530; hsa04666; hsa04750; hsa04925; hsa04930; hsa04931; hsa04933; hsa05206 2WH0


3 known interactions (drugs) of input target (PRKCE): Protein kinase C epsilon type
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Investigational SmallMoleculeDrug DB06064 KAI-1455 Thumb
2 Approved;
Investigational		 SmallMoleculeDrug DB12010 Fostamatinib Thumb
3 Approved SmallMoleculeDrug DB00675 Tamoxifen Thumb


20 predicted interactions (drugs) of input target (PRKCE): Protein kinase C epsilon type
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB08896 Regorafenib Thumb 21.7%
2 Approved;
Investigational		 SmallMoleculeDrug DB08901 Ponatinib Thumb 21.5%
3 Experimental SmallMoleculeDrug DB02010 Staurosporine Thumb 21.0%
4 Approved;
Nutraceutical		 SmallMoleculeDrug DB00126 Vitamin C Thumb 19.5%
5 Approved;
Vet approved		 SmallMoleculeDrug DB00945 Acetylsalicylic acid Thumb 17.8%
6 Experimental SmallMoleculeDrug DB04395 Phosphoaminophosphonic Acid-Adenylate Ester Thumb 17.7%
7 Approved SmallMoleculeDrug DB00619 Imatinib Thumb 17.6%
8 Approved SmallMoleculeDrug DB05013 Ingenol Mebutate Thumb 17.2%
9 Approved;
Vet approved		 SmallMoleculeDrug DB00396 Progesterone Thumb 16.8%
10 Approved SmallMoleculeDrug DB05294 Vandetanib Thumb 16.6%
11 Approved;
Investigational		 SmallMoleculeDrug DB06217 Vernakalant Thumb 16.1%
12 Approved;
Investigational		 SmallMoleculeDrug DB01254 Dasatinib Thumb 15.6%
13 Approved SmallMoleculeDrug DB09079 Nintedanib Thumb 15.5%
14 Approved;
Investigational		 SmallMoleculeDrug DB12267 Brigatinib Thumb 15.4%
15 Experimental SmallMoleculeDrug DB06884 4-HYDROXY-N'-(4-ISOPROPYLBENZYL)BENZOHYDRAZIDE Thumb 15.0%
16 Experimental SmallMoleculeDrug DB03777 Rbt205 Inhibitor Thumb 14.8%
17 Approved SmallMoleculeDrug DB00280 Disopyramide Thumb 14.8%
18 Approved;
Investigational		 BiotechDrug DB11767 Sarilumab Thumb 14.8%
19 Approved SmallMoleculeDrug DB06637 Dalfampridine Thumb 14.1%
20 Approved;
Investigational		 BiotechDrug DB00112 Bevacizumab Thumb 14.0%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.