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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P35367
No. Gene UniProt ID Protein Name Pathway PDB
1 HRH1 P35367 Histamine H1 receptor hsa04020; hsa04080; hsa04750 3RZE


104 known interactions (drugs) of input target (HRH1): Histamine H1 receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Investigational SmallMoleculeDrug DB06678 Esmirtazapine Thumb
2 Approved SmallMoleculeDrug DB08936 Chlorcyclizine Thumb
3 Approved SmallMoleculeDrug DB00920 Ketotifen Thumb
4 Approved SmallMoleculeDrug DB00434 Cyproheptadine Thumb
5 Approved SmallMoleculeDrug DB01267 Paliperidone Thumb
6 Approved SmallMoleculeDrug DB01224 Quetiapine Thumb
7 Approved SmallMoleculeDrug DB01619 Phenindamine Thumb
8 Approved SmallMoleculeDrug DB00748 Carbinoxamine Thumb
9 Approved;
Investigational		 SmallMoleculeDrug DB06016 Cariprazine Thumb
10 Approved SmallMoleculeDrug DB00363 Clozapine Thumb
11 Approved;
Investigational		 SmallMoleculeDrug DB11591 Bilastine Thumb
12 Approved SmallMoleculeDrug DB04946 Iloperidone Thumb
13 Approved;
Withdrawn		 SmallMoleculeDrug DB00637 Astemizole Thumb
14 Approved SmallMoleculeDrug DB11614 Rupatadine Thumb
15 Approved;
Investigational		 SmallMoleculeDrug DB05381 Histamine Thumb
16 Approved;
Vet approved		 SmallMoleculeDrug DB00366 Doxylamine Thumb
17 Approved;
Investigational		 SmallMoleculeDrug DB00734 Risperidone Thumb
18 Approved SmallMoleculeDrug DB00405 Dexbrompheniramine Thumb
19 Approved SmallMoleculeDrug DB09167 Dosulepin Thumb
20 Approved SmallMoleculeDrug DB09488 Acrivastine Thumb
21 Approved SmallMoleculeDrug DB01173 Orphenadrine Thumb
22 Approved SmallMoleculeDrug DB01237 Bromodiphenhydramine Thumb
23 Approved;
Investigational		 SmallMoleculeDrug DB01142 Doxepin Thumb
24 Approved SmallMoleculeDrug DB01176 Cyclizine Thumb
25 Approved;
Investigational		 SmallMoleculeDrug DB00334 Olanzapine Thumb
26 Withdrawn SmallMoleculeDrug DB00767 Benzquinamide Thumb
27 Approved SmallMoleculeDrug DB00408 Loxapine Thumb
28 Approved SmallMoleculeDrug DB08802 Isothipendyl Thumb
29 Approved;
Vet approved		 SmallMoleculeDrug DB06691 Mepyramine Thumb
30 Approved;
Investigational		 SmallMoleculeDrug DB00656 Trazodone Thumb
31 Approved;
Investigational		 SmallMoleculeDrug DB01175 Escitalopram Thumb
32 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB01239 Chlorprothixene Thumb
33 Investigational SmallMoleculeDrug DB05492 Epicept NP-1 Thumb
34 Approved SmallMoleculeDrug DB00835 Brompheniramine Thumb
35 Approved SmallMoleculeDrug DB01114 Chlorphenamine Thumb
36 Approved;
Investigational		 SmallMoleculeDrug DB01238 Aripiprazole Thumb
37 Approved SmallMoleculeDrug DB08922 Perospirone Thumb
38 Approved SmallMoleculeDrug DB01084 Emedastine Thumb
39 Approved;
Investigational		 SmallMoleculeDrug DB00555 Lamotrigine Thumb
40 Approved SmallMoleculeDrug DB00737 Meclizine Thumb
41 Approved SmallMoleculeDrug DB00902 Methdilazine Thumb
42 Approved SmallMoleculeDrug DB00768 Olopatadine Thumb
43 Approved;
Investigational		 SmallMoleculeDrug DB00950 Fexofenadine Thumb
44 Approved;
Investigational		 SmallMoleculeDrug DB01624 Zuclopenthixol Thumb
45 Approved SmallMoleculeDrug DB00246 Ziprasidone Thumb
46 Approved;
Investigational		 SmallMoleculeDrug DB00751 Epinastine Thumb
47 Approved;
Investigational		 SmallMoleculeDrug DB01146 Diphenylpyraline Thumb
48 Approved SmallMoleculeDrug DB00370 Mirtazapine Thumb
49 Approved SmallMoleculeDrug DB00341 Cetirizine Thumb
50 Approved;
Investigational		 SmallMoleculeDrug DB00455 Loratadine Thumb
51 Approved SmallMoleculeDrug DB06766 Alcaftadine Thumb
52 Approved;
Investigational		 SmallMoleculeDrug DB00568 Cinnarizine Thumb
53 Approved SmallMoleculeDrug DB00427 Triprolidine Thumb
54 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb
55 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb
56 Approved SmallMoleculeDrug DB00354 Buclizine Thumb
57 Approved SmallMoleculeDrug DB00245 Benzatropine Thumb
58 Approved;
Investigational		 SmallMoleculeDrug DB00283 Clemastine Thumb
59 Approved;
Investigational		 SmallMoleculeDrug DB06148 Mianserin Thumb
60 Approved SmallMoleculeDrug DB00458 Imipramine Thumb
61 Approved SmallMoleculeDrug DB11235 Thonzylamine Thumb
62 Investigational SmallMoleculeDrug DB05345 SO-101 Thumb
63 Approved SmallMoleculeDrug DB00215 Citalopram Thumb
64 Investigational SmallMoleculeDrug DB05080 OBE101 Thumb
65 Approved SmallMoleculeDrug DB08799 Antazoline Thumb
66 Approved SmallMoleculeDrug DB09195 Lorpiprazole Thumb
67 Approved;
Investigational		 SmallMoleculeDrug DB01069 Promethazine Thumb
68 Approved;
Vet approved		 SmallMoleculeDrug DB00792 Tripelennamine Thumb
69 Approved SmallMoleculeDrug DB09016 Butriptyline Thumb
70 Approved SmallMoleculeDrug DB09555 Dexchlorpheniramine maleate Thumb
71 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb
72 Approved SmallMoleculeDrug DB06216 Asenapine Thumb
73 Approved;
Investigational		 SmallMoleculeDrug DB00967 Desloratadine Thumb
74 Approved;
Withdrawn		 SmallMoleculeDrug DB04837 Clofedanol Thumb
75 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00477 Chlorpromazine Thumb
76 Approved;
Investigational		 SmallMoleculeDrug DB08801 Dimetindene Thumb
77 Approved SmallMoleculeDrug DB08800 Chloropyramine Thumb
78 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb
79 Approved SmallMoleculeDrug DB01071 Mequitazine Thumb
80 Approved;
Investigational		 SmallMoleculeDrug DB00934 Maprotiline Thumb
81 Approved;
Investigational		 SmallMoleculeDrug DB01075 Diphenhydramine Thumb
82 Investigational SmallMoleculeDrug DB04905 Tesmilifene Thumb
83 Approved;
Withdrawn		 SmallMoleculeDrug DB00342 Terfenadine Thumb
84 Investigational SmallMoleculeDrug DB06229 Ocaperidone Thumb
85 Approved SmallMoleculeDrug DB01615 Aceprometazine Thumb
86 Approved SmallMoleculeDrug DB06153 Pizotifen Thumb
87 Approved;
Investigational		 SmallMoleculeDrug DB01106 Levocabastine Thumb
88 Approved SmallMoleculeDrug DB00985 Dimenhydrinate Thumb
89 Investigational SmallMoleculeDrug DB05079 HY10275 Thumb
90 Approved SmallMoleculeDrug DB00557 Hydroxyzine Thumb
91 Approved;
Vet approved		 SmallMoleculeDrug DB00797 Tolazoline Thumb
92 Approved;
Vet approved		 SmallMoleculeDrug DB01246 Alimemazine Thumb
93 Approved SmallMoleculeDrug DB00972 Azelastine Thumb
94 Approved SmallMoleculeDrug DB04841 Flunarizine Thumb
95 Approved;
Investigational		 SmallMoleculeDrug DB01151 Desipramine Thumb
96 Approved;
Investigational		 SmallMoleculeDrug DB06698 Betahistine Thumb
97 Approved;
Investigational		 SmallMoleculeDrug DB14185 Aripiprazole lauroxil Thumb
98 Approved;
Vet approved		 SmallMoleculeDrug DB00420 Promazine Thumb
99 Approved SmallMoleculeDrug DB04890 Bepotastine Thumb
100 Approved SmallMoleculeDrug DB00719 Azatadine Thumb
101 Approved SmallMoleculeDrug DB01620 Pheniramine Thumb
102 Approved;
Investigational		 SmallMoleculeDrug DB01403 Methotrimeprazine Thumb
103 Approved SmallMoleculeDrug DB06282 Levocetirizine Thumb
104 Approved SmallMoleculeDrug DB00777 Propiomazine Thumb


20 predicted interactions (drugs) of input target (HRH1): Histamine H1 receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Withdrawn SmallMoleculeDrug DB09194 Etoperidone Thumb 83.2%
2 Approved;
Investigational		 SmallMoleculeDrug DB09286 Pipamperone Thumb 82.2%
3 Approved;
Investigational		 SmallMoleculeDrug DB00193 Tramadol Thumb 81.5%
4 Approved SmallMoleculeDrug DB00800 Fenoldopam Thumb 79.5%
5 Approved SmallMoleculeDrug DB00696 Ergotamine Thumb 78.3%
6 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB09225 Zotepine Thumb 76.9%
7 Approved;
Withdrawn		 SmallMoleculeDrug DB01149 Nefazodone Thumb 75.9%
8 Approved;
Illicit		 SmallMoleculeDrug DB01579 Phendimetrazine Thumb 74.6%
9 Approved;
Investigational		 SmallMoleculeDrug DB09128 Brexpiprazole Thumb 74.3%
10 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB00875 Flupentixol Thumb 73.5%
11 Approved;
Investigational		 SmallMoleculeDrug DB08815 Lurasidone Thumb 72.7%
12 Approved SmallMoleculeDrug DB00805 Minaprine Thumb 72.6%
13 Approved;
Investigational		 SmallMoleculeDrug DB01608 Propericiazine Thumb 72.5%
14 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB06144 Sertindole Thumb 71.3%
15 Approved;
Vet approved		 SmallMoleculeDrug DB00508 Triflupromazine Thumb 71.2%
16 Approved SmallMoleculeDrug DB00988 Dopamine Thumb 70.9%
17 Approved SmallMoleculeDrug DB01622 Thioproperazine Thumb 70.4%
18 Approved;
Investigational		 SmallMoleculeDrug DB00589 Lisuride Thumb 70.4%
19 Approved;
Investigational		 SmallMoleculeDrug DB00715 Paroxetine Thumb 70.4%
20 Approved;
Vet approved		 SmallMoleculeDrug DB01614 Acepromazine Thumb 70.3%


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.