QuartataWeb
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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q16832
No. Gene UniProt ID Protein Name Pathway PDB
1 DDR2 Q16832 Discoidin domain-containing receptor 2 NA 2WUH; 2Z4F


2 known interactions (drugs) of input target (DDR2): Discoidin domain-containing receptor 2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational		 SmallMoleculeDrug DB12010 Fostamatinib Thumb
2 Approved SmallMoleculeDrug DB08896 Regorafenib Thumb


20 predicted interactions (drugs) of input target (DDR2): Discoidin domain-containing receptor 2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 SmallMoleculeDrug DB01254 Dasatinib Thumb 43.2%
2 Approved;
Investigational		 SmallMoleculeDrug DB08901 Ponatinib Thumb 34.4%
3 Approved;
Investigational		 SmallMoleculeDrug DB00398 Sorafenib Thumb 30.1%
4 Approved SmallMoleculeDrug DB00619 Imatinib Thumb 28.9%
5 Investigational SmallMoleculeDrug DB05146 XL820 Thumb 28.7%
6 Approved SmallMoleculeDrug DB06589 Pazopanib Thumb 25.9%
7 Approved SmallMoleculeDrug DB05294 Vandetanib Thumb 25.3%
8 Experimental SmallMoleculeDrug DB04395 Phosphoaminophosphonic Acid-Adenylate Ester Thumb 24.1%
9 Experimental SmallMoleculeDrug DB02010 Staurosporine Thumb 23.4%
10 Approved;
Investigational		 SmallMoleculeDrug DB08912 Dabrafenib Thumb 23.3%
11 Approved;
Investigational		 SmallMoleculeDrug DB09078 Lenvatinib Thumb 23.3%
12 Investigational SmallMoleculeDrug DB12742 Amuvatinib Thumb 23.2%
13 Approved SmallMoleculeDrug DB09079 Nintedanib Thumb 22.6%
14 Approved;
Investigational		 SmallMoleculeDrug DB01268 Sunitinib Thumb 21.6%
15 Investigational SmallMoleculeDrug DB05157 KC706 Thumb 21.3%
16 Approved;
Investigational		 SmallMoleculeDrug DB06595 Midostaurin Thumb 19.9%
17 Experimental SmallMoleculeDrug DB02058 SU4984 Thumb 19.7%
18 Investigational SmallMoleculeDrug DB05075 TG-100801 Thumb 19.6%
19 Investigational SmallMoleculeDrug DB05014 XL999 Thumb 19.0%
20 Approved BiotechDrug DB00039 Palifermin Thumb 18.4%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.