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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P21917
No. Gene UniProt ID Protein Name Pathway PDB
1 DRD4 P21917 D(4) dopamine receptor hsa04080; hsa04728 NA


36 known interactions (drugs) of input target (DRD4): D(4) dopamine receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Investigational SmallMoleculeDrug DB12061 Pardoprunox Thumb
2 Approved;
Investigational		 SmallMoleculeDrug DB00714 Apomorphine Thumb
3 Approved;
Investigational		 SmallMoleculeDrug DB00589 Lisuride Thumb
4 Approved SmallMoleculeDrug DB00408 Loxapine Thumb
5 Approved;
Investigational		 SmallMoleculeDrug DB04908 Flibanserin Thumb
6 Approved SmallMoleculeDrug DB01267 Paliperidone Thumb
7 Approved SmallMoleculeDrug DB11275 Epicriptine Thumb
8 Approved SmallMoleculeDrug DB00248 Cabergoline Thumb
9 Approved SmallMoleculeDrug DB01224 Quetiapine Thumb
10 Withdrawn SmallMoleculeDrug DB00372 Thiethylperazine Thumb
11 Approved;
Investigational		 SmallMoleculeDrug DB01200 Bromocriptine Thumb
12 Approved SmallMoleculeDrug DB00988 Dopamine Thumb
13 Approved;
Investigational		 SmallMoleculeDrug DB09286 Pipamperone Thumb
14 Approved SmallMoleculeDrug DB04946 Iloperidone Thumb
15 Approved;
Experimental		 SmallMoleculeDrug DB13345 Dihydroergocristine Thumb
16 Approved;
Investigational		 SmallMoleculeDrug DB01238 Aripiprazole Thumb
17 Approved SmallMoleculeDrug DB01235 Levodopa Thumb
18 Approved;
Investigational;
Vet approved;
Withdrawn		 SmallMoleculeDrug DB01186 Pergolide Thumb
19 Approved SmallMoleculeDrug DB08922 Perospirone Thumb
20 Approved SmallMoleculeDrug DB05271 Rotigotine Thumb
21 Approved;
Investigational		 SmallMoleculeDrug DB00734 Risperidone Thumb
22 Approved SmallMoleculeDrug DB00363 Clozapine Thumb
23 Approved;
Investigational		 SmallMoleculeDrug DB14185 Aripiprazole lauroxil Thumb
24 Investigational SmallMoleculeDrug DB06477 Sumanirole Thumb
25 Approved;
Vet approved		 SmallMoleculeDrug DB00420 Promazine Thumb
26 Approved SmallMoleculeDrug DB06216 Asenapine Thumb
27 Approved;
Withdrawn		 SmallMoleculeDrug DB00409 Remoxipride Thumb
28 Approved;
Investigational		 SmallMoleculeDrug DB00268 Ropinirole Thumb
29 Approved SmallMoleculeDrug DB01049 Ergoloid mesylate Thumb
30 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00477 Chlorpromazine Thumb
31 Approved SmallMoleculeDrug DB00246 Ziprasidone Thumb
32 Approved;
Investigational		 SmallMoleculeDrug DB00413 Pramipexole Thumb
33 Approved;
Investigational		 SmallMoleculeDrug DB01403 Methotrimeprazine Thumb
34 Approved;
Investigational		 SmallMoleculeDrug DB00334 Olanzapine Thumb
35 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb
36 Approved SmallMoleculeDrug DB00777 Propiomazine Thumb


20 predicted interactions (drugs) of input target (DRD4): D(4) dopamine receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 SmallMoleculeDrug DB01142 Doxepin Thumb 87.9%
2 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb 87.1%
3 Approved;
Investigational		 SmallMoleculeDrug DB13025 Tiapride Thumb 86.1%
4 Approved;
Investigational		 SmallMoleculeDrug DB06148 Mianserin Thumb 86.0%
5 Approved SmallMoleculeDrug DB00458 Imipramine Thumb 83.7%
6 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01392 Yohimbine Thumb 83.0%
7 Approved SmallMoleculeDrug DB06153 Pizotifen Thumb 82.7%
8 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb 82.6%
9 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB01239 Chlorprothixene Thumb 82.2%
10 Approved;
Vet approved		 SmallMoleculeDrug DB01614 Acepromazine Thumb 80.8%
11 Approved SmallMoleculeDrug DB00370 Mirtazapine Thumb 80.4%
12 Approved SmallMoleculeDrug DB01622 Thioproperazine Thumb 79.8%
13 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb 79.8%
14 Approved;
Investigational		 SmallMoleculeDrug DB00555 Lamotrigine Thumb 79.7%
15 Approved;
Investigational		 SmallMoleculeDrug DB01151 Desipramine Thumb 79.3%
16 Approved;
Investigational		 SmallMoleculeDrug DB00934 Maprotiline Thumb 79.1%
17 Approved;
Investigational		 SmallMoleculeDrug DB04948 Lofexidine Thumb 78.6%
18 Approved;
Investigational		 SmallMoleculeDrug DB06016 Cariprazine Thumb 78.4%
19 Approved;
Investigational		 SmallMoleculeDrug DB06288 Amisulpride Thumb 78.3%
20 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB09225 Zotepine Thumb 77.8%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.