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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q96C86
No. Gene UniProt ID Protein Name Pathway PDB
1 DCPS Q96C86 m7GpppX diphosphatase hsa03018 1ST0; 1ST4; 1XML; 1XMM; 3BL7; 3BL9; 3BLA; 4QDE; 4QDV; 4QEB


7 known interactions (drugs) of input target (DCPS): m7GpppX diphosphatase
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Experimental SmallMoleculeDrug DB01960 7n-Methyl-8-Hydroguanosine-5'-Diphosphate Thumb
2 Experimental SmallMoleculeDrug DB03593 N7-Methyl-Guanosine-5'-Monophosphate Thumb
3 Experimental SmallMoleculeDrug DB01649 7-Methyl-Gpppa Thumb
4 Experimental SmallMoleculeDrug DB07644 5-[(1S)-1-(3-chlorophenyl)ethoxy]quinazoline-2,4-diamine Thumb
5 Experimental SmallMoleculeDrug DB07643 5-{[1-(2,3-dichlorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine Thumb
6 Experimental SmallMoleculeDrug DB03958 7-methyl-guanosine-5'-triphosphate-5'-guanosine Thumb
7 Experimental SmallMoleculeDrug DB07642 5-{[1-(2-fluorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine Thumb


20 predicted interactions (drugs) of input target (DCPS): m7GpppX diphosphatase
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Nutraceutical		 SmallMoleculeDrug DB00128 L-Aspartic Acid Thumb 31.1%
2 Approved;
Investigational		 SmallMoleculeDrug DB12965 Silver Thumb 25.8%
3 Experimental SmallMoleculeDrug DB02716 7-Methyl-Guanosine-5'-Triphosphate Thumb 25.2%
4 Investigational SmallMoleculeDrug DB05165 LY2275796 Thumb 23.1%
5 Approved SmallMoleculeDrug DB01327 Cefazolin Thumb 22.6%
6 Approved;
Nutraceutical;
Vet approved		 SmallMoleculeDrug DB00162 Vitamin A Thumb 22.5%
7 Approved SmallMoleculeDrug DB00852 Pseudoephedrine Thumb 22.4%
8 Investigational SmallMoleculeDrug DB06248 Amelubant Thumb 21.6%
9 Approved;
Nutraceutical		 SmallMoleculeDrug DB00172 L-Proline Thumb 20.2%
10 Approved SmallMoleculeDrug DB00364 Sucralfate Thumb 19.7%
11 Approved SmallMoleculeDrug DB00333 Methadone Thumb 19.3%
12 Experimental SmallMoleculeDrug DB01375 Aluminium monostearate Thumb 18.9%
13 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00254 Doxycycline Thumb 18.0%
14 Approved;
Investigational		 SmallMoleculeDrug DB14011 Nabiximols Thumb 17.8%
15 Experimental SmallMoleculeDrug DB08240 N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE Thumb 17.8%
16 Approved;
Vet approved		 SmallMoleculeDrug DB00759 Tetracycline Thumb 17.4%
17 Approved;
Investigational		 BiotechDrug DB13998 Lonoctocog alfa Thumb 16.8%
18 Experimental SmallMoleculeDrug DB08080 LATRUNCULIN B Thumb 16.6%
19 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00627 Niacin Thumb 16.5%
20 Approved;
Investigational		 SmallMoleculeDrug DB09061 Cannabidiol Thumb 16.2%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.