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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P28222
No. Gene UniProt ID Protein Name Pathway PDB
1 HTR1B P28222 5-hydroxytryptamine receptor 1B hsa04024; hsa04080; hsa04726; hsa04742 2G1X; 4IAQ; 4IAR


43 known interactions (drugs) of input target (HTR1B): 5-hydroxytryptamine receptor 1B
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational		 SmallMoleculeDrug DB00571 Propranolol Thumb
2 Investigational SmallMoleculeDrug DB04884 Dapoxetine Thumb
3 Approved SmallMoleculeDrug DB00696 Ergotamine Thumb
4 Approved;
Investigational		 SmallMoleculeDrug DB00714 Apomorphine Thumb
5 Approved;
Investigational		 SmallMoleculeDrug DB00589 Lisuride Thumb
6 Approved;
Vet approved		 SmallMoleculeDrug DB01221 Ketamine Thumb
7 Approved SmallMoleculeDrug DB00408 Loxapine Thumb
8 Approved;
Investigational		 SmallMoleculeDrug DB00952 Naratriptan Thumb
9 Approved;
Investigational		 SmallMoleculeDrug DB00216 Eletriptan Thumb
10 Approved;
Experimental		 SmallMoleculeDrug DB13345 Dihydroergocristine Thumb
11 Approved SmallMoleculeDrug DB00248 Cabergoline Thumb
12 Approved SmallMoleculeDrug DB01224 Quetiapine Thumb
13 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb
14 Approved;
Investigational		 SmallMoleculeDrug DB00998 Frovatriptan Thumb
15 Approved SmallMoleculeDrug DB06153 Pizotifen Thumb
16 Approved;
Investigational		 SmallMoleculeDrug DB01200 Bromocriptine Thumb
17 Approved;
Investigational		 SmallMoleculeDrug DB01359 Penbutolol Thumb
18 Approved;
Investigational		 SmallMoleculeDrug DB13025 Tiapride Thumb
19 Approved SmallMoleculeDrug DB00363 Clozapine Thumb
20 Approved SmallMoleculeDrug DB00904 Ondansetron Thumb
21 Approved;
Investigational		 SmallMoleculeDrug DB00918 Almotriptan Thumb
22 Approved SmallMoleculeDrug DB08807 Bopindolol Thumb
23 Approved;
Investigational		 SmallMoleculeDrug DB00268 Ropinirole Thumb
24 Approved;
Investigational		 SmallMoleculeDrug DB09068 Vortioxetine Thumb
25 Approved;
Investigational		 SmallMoleculeDrug DB00320 Dihydroergotamine Thumb
26 Approved SmallMoleculeDrug DB00247 Methysergide Thumb
27 Investigational SmallMoleculeDrug DB06096 NXN-188 Thumb
28 Approved;
Investigational		 SmallMoleculeDrug DB01238 Aripiprazole Thumb
29 Approved;
Investigational		 SmallMoleculeDrug DB00315 Zolmitriptan Thumb
30 Approved;
Investigational		 SmallMoleculeDrug DB00960 Pindolol Thumb
31 Approved SmallMoleculeDrug DB09304 Setiptiline Thumb
32 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01392 Yohimbine Thumb
33 Approved;
Investigational		 SmallMoleculeDrug DB14185 Aripiprazole lauroxil Thumb
34 Approved;
Investigational		 SmallMoleculeDrug DB00669 Sumatriptan Thumb
35 Approved SmallMoleculeDrug DB06216 Asenapine Thumb
36 Approved SmallMoleculeDrug DB11273 Dihydroergocornine Thumb
37 Approved SmallMoleculeDrug DB00246 Ziprasidone Thumb
38 Approved SmallMoleculeDrug DB01049 Ergoloid mesylate Thumb
39 Approved SmallMoleculeDrug DB00953 Rizatriptan Thumb
40 Approved;
Investigational;
Vet approved;
Withdrawn		 SmallMoleculeDrug DB01186 Pergolide Thumb
41 Approved;
Investigational		 SmallMoleculeDrug DB00413 Pramipexole Thumb
42 Approved;
Investigational		 SmallMoleculeDrug DB00334 Olanzapine Thumb
43 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb


20 predicted interactions (drugs) of input target (HTR1B): 5-hydroxytryptamine receptor 1B
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 SmallMoleculeDrug DB04948 Lofexidine Thumb 89.1%
2 Approved SmallMoleculeDrug DB01267 Paliperidone Thumb 89.0%
3 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb 86.0%
4 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00477 Chlorpromazine Thumb 83.8%
5 Approved;
Investigational		 SmallMoleculeDrug DB06148 Mianserin Thumb 83.2%
6 Approved;
Investigational		 SmallMoleculeDrug DB00734 Risperidone Thumb 81.5%
7 Approved;
Investigational		 SmallMoleculeDrug DB01142 Doxepin Thumb 80.0%
8 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb 78.9%
9 Approved SmallMoleculeDrug DB04946 Iloperidone Thumb 78.7%
10 Approved;
Investigational		 SmallMoleculeDrug DB01151 Desipramine Thumb 76.8%
11 Approved SmallMoleculeDrug DB00370 Mirtazapine Thumb 76.4%
12 Approved SmallMoleculeDrug DB00458 Imipramine Thumb 75.5%
13 Approved;
Investigational		 SmallMoleculeDrug DB00934 Maprotiline Thumb 74.8%
14 Approved;
Investigational		 SmallMoleculeDrug DB08815 Lurasidone Thumb 73.4%
15 Approved;
Investigational		 SmallMoleculeDrug DB01403 Methotrimeprazine Thumb 73.1%
16 Approved SmallMoleculeDrug DB00988 Dopamine Thumb 71.6%
17 Illicit;
Investigational;
Withdrawn		 SmallMoleculeDrug DB04829 Lysergic Acid Diethylamide Thumb 70.6%
18 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB06144 Sertindole Thumb 70.3%
19 Approved;
Investigational		 SmallMoleculeDrug DB00751 Epinastine Thumb 69.8%
20 Approved SmallMoleculeDrug DB08922 Perospirone Thumb 69.1%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.