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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q8IZS8
No. Gene UniProt ID Protein Name Pathway PDB
1 CACNA2D3 Q8IZS8 Voltage-dependent calcium channel subunit alpha-2/delta-3 hsa04010; hsa04260; hsa04261; hsa04921; hsa05410; hsa05412; hsa05414 NA


4 known interactions (drugs) of input target (CACNA2D3): Voltage-dependent calcium channel subunit alpha-2/delta-3
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved SmallMoleculeDrug DB00421 Spironolactone Thumb
2 Approved;
Investigational		 SmallMoleculeDrug DB06712 Nilvadipine Thumb
3 Approved;
Withdrawn		 SmallMoleculeDrug DB11148 Butamben Thumb
4 Approved SmallMoleculeDrug DB00381 Amlodipine Thumb


20 predicted interactions (drugs) of input target (CACNA2D3): Voltage-dependent calcium channel subunit alpha-2/delta-3
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB00661 Verapamil Thumb 57.1%
2 Approved;
Experimental		 SmallMoleculeDrug DB13746 Bioallethrin Thumb 54.9%
3 Approved;
Investigational		 SmallMoleculeDrug DB01054 Nitrendipine Thumb 52.7%
4 Approved;
Investigational		 SmallMoleculeDrug DB01023 Felodipine Thumb 51.0%
5 Approved;
Investigational		 SmallMoleculeDrug DB09231 Benidipine Thumb 49.3%
6 Approved SmallMoleculeDrug DB01115 Nifedipine Thumb 49.0%
7 Approved;
Investigational		 SmallMoleculeDrug DB00270 Isradipine Thumb 48.8%
8 Approved;
Investigational		 SmallMoleculeDrug DB00393 Nimodipine Thumb 48.3%
9 Approved;
Investigational		 SmallMoleculeDrug DB09232 Cilnidipine Thumb 46.6%
10 Investigational;
Withdrawn		 SmallMoleculeDrug DB01388 Mibefradil Thumb 45.4%
11 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00653 Magnesium sulfate Thumb 44.8%
12 Approved SmallMoleculeDrug DB00401 Nisoldipine Thumb 43.7%
13 Approved;
Nutraceutical		 SmallMoleculeDrug DB13961 Fish oil Thumb 42.9%
14 Approved SmallMoleculeDrug DB04855 Dronedarone Thumb 42.1%
15 Approved;
Investigational		 SmallMoleculeDrug DB09238 Manidipine Thumb 42.1%
16 Approved SmallMoleculeDrug DB00825 Menthol Thumb 41.9%
17 Approved SmallMoleculeDrug DB00308 Ibutilide Thumb 40.7%
18 Approved;
Investigational		 SmallMoleculeDrug DB00622 Nicardipine Thumb 40.6%
19 Approved;
Investigational		 SmallMoleculeDrug DB00568 Cinnarizine Thumb 39.8%
20 Approved;
Investigational		 SmallMoleculeDrug DB09236 Lacidipine Thumb 39.4%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.