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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q9UBS5
No. Gene UniProt ID Protein Name Pathway PDB
1 GABBR1 Q9UBS5 Gamma-aminobutyric acid type B receptor subunit 1 hsa04024; hsa04080; hsa04727; hsa04742; hsa04915; hsa05032 4MQE; 4MQF; 4MR7; 4MR8; 4MR9; 4MRM; 4MS1; 4MS3; 4MS4; 4PAS


10 known interactions (drugs) of input target (GABBR1): Gamma-aminobutyric acid type B receptor subunit 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Nutraceutical		 SmallMoleculeDrug DB01956 Taurine Thumb
2 Approved SmallMoleculeDrug DB01080 Vigabatrin Thumb
3 Approved;
Investigational		 SmallMoleculeDrug DB00996 Gabapentin Thumb
4 Investigational SmallMoleculeDrug DB05010 SGS-742 Thumb
5 Investigational SmallMoleculeDrug DB08892 Arbaclofen Placarbil Thumb
6 Approved;
Investigational		 SmallMoleculeDrug DB00837 Progabide Thumb
7 Approved SmallMoleculeDrug DB00181 Baclofen Thumb
8 Investigational SmallMoleculeDrug DB06354 Tezampanel Thumb
9 Approved;
Investigational		 SmallMoleculeDrug DB02530 gamma-Aminobutyric acid Thumb
10 Investigational SmallMoleculeDrug DB08891 Arbaclofen Thumb


20 predicted interactions (drugs) of input target (GABBR1): Gamma-aminobutyric acid type B receptor subunit 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB00898 Ethanol Thumb 54.7%
2 Approved;
Investigational		 SmallMoleculeDrug DB00659 Acamprosate Thumb 47.6%
3 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB01708 Prasterone Thumb 43.2%
4 Approved;
Vet approved		 SmallMoleculeDrug DB00753 Isoflurane Thumb 42.8%
5 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00312 Pentobarbital Thumb 40.0%
6 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00119 Pyruvic acid Thumb 38.2%
7 Approved SmallMoleculeDrug DB00273 Topiramate Thumb 37.9%
8 Approved SmallMoleculeDrug DB01587 Ketazolam Thumb 36.1%
9 Approved;
Vet approved		 SmallMoleculeDrug DB00418 Secobarbital Thumb 35.8%
10 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB00475 Chlordiazepoxide Thumb 35.5%
11 Approved;
Vet approved		 SmallMoleculeDrug DB01159 Halothane Thumb 35.2%
12 Approved SmallMoleculeDrug DB01594 Cinolazepam Thumb 35.1%
13 Approved;
Investigational		 SmallMoleculeDrug DB09462 Glycerin Thumb 35.0%
14 Approved;
Illicit		 SmallMoleculeDrug DB01544 Flunitrazepam Thumb 34.8%
15 Approved;
Illicit		 SmallMoleculeDrug DB00237 Butabarbital Thumb 34.5%
16 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00818 Propofol Thumb 34.3%
17 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00228 Enflurane Thumb 34.0%
18 Approved;
Illicit		 SmallMoleculeDrug DB00306 Talbutal Thumb 33.9%
19 Approved;
Investigational		 SmallMoleculeDrug DB00555 Lamotrigine Thumb 33.7%
20 Approved;
Investigational		 SmallMoleculeDrug DB11901 Apalutamide Thumb 32.9%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.