QuartataWeb
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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q6V0L0
No. Gene UniProt ID Protein Name Pathway PDB
1 CYP26C1 Q6V0L0 Cytochrome P450 26C1 hsa00830; hsa01100 NA


2 known interactions (drugs) of input target (CYP26C1): Cytochrome P450 26C1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00755 Tretinoin Thumb
2 Approved;
Investigational		 SmallMoleculeDrug DB00523 Alitretinoin Thumb


20 predicted interactions (drugs) of input target (CYP26C1): Cytochrome P450 26C1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB00210 Adapalene Thumb 41.2%
2 Approved SmallMoleculeDrug DB00459 Acitretin Thumb 39.7%
3 Withdrawn SmallMoleculeDrug DB00926 Etretinate Thumb 39.6%
4 Investigational SmallMoleculeDrug DB05785 LGD-1550 Thumb 33.0%
5 Approved;
Investigational		 SmallMoleculeDrug DB00799 Tazarotene Thumb 31.4%
6 Approved;
Investigational		 SmallMoleculeDrug DB04942 Tamibarotene Thumb 24.6%
7 Approved;
Investigational		 SmallMoleculeDrug DB01593 Zinc Thumb 22.4%
8 Approved;
Investigational		 SmallMoleculeDrug DB00307 Bexarotene Thumb 21.0%
9 Approved;
Nutraceutical		 SmallMoleculeDrug DB00157 NADH Thumb 20.5%
10 Approved;
Investigational		 SmallMoleculeDrug DB03756 Doconexent Thumb 20.1%
11 Experimental SmallMoleculeDrug DB02746 Phthalic Acid Thumb 19.4%
12 Approved;
Nutraceutical		 SmallMoleculeDrug DB01436 Alfacalcidol Thumb 19.0%
13 Experimental SmallMoleculeDrug DB02877 Arotinoid acid Thumb 18.8%
14 Investigational SmallMoleculeDrug DB05467 R667 Thumb 18.5%
15 Experimental SmallMoleculeDrug DB02466 4-[3-Oxo-3-(5,5,8,8-Tetramethyl-5,6,7,8-Tetrahydro-Naphthalen-2-Yl)-Propenyl]-Benzoic Acid Thumb 17.5%
16 Experimental SmallMoleculeDrug DB02258 SR11254 Thumb 16.7%
17 Experimental SmallMoleculeDrug DB07557 (5BETA)-PREGNANE-3,20-DIONE Thumb 16.7%
18 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00749 Etodolac Thumb 16.7%
19 Approved;
Investigational		 SmallMoleculeDrug DB01393 Bezafibrate Thumb 16.7%
20 Experimental SmallMoleculeDrug DB08601 tributylstannanyl Thumb 16.5%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.