QuartataWeb
Home  |   About  |   Theory  |   Tutorials  |   FAQ  |   Bahar Lab  |   Statistics
 

Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P62714
No. Gene UniProt ID Protein Name Pathway PDB
1 PPP2CB P62714 Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform hsa03015; hsa04071; hsa04114; hsa04136; hsa04140; hsa04151; hsa04152; hsa04261; hsa04350; hsa04390; hsa04530; hsa04728; hsa04730; hsa05142; hsa05160; hsa05165 NA


3 known interactions (drugs) of input target (PPP2CB): Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Nutraceutical;
Vet approved		 SmallMoleculeDrug DB14001 alpha-Tocopherol succinate Thumb
2 Approved;
Nutraceutical;
Vet approved		 SmallMoleculeDrug DB00163 Vitamin E Thumb
3 Approved;
Nutraceutical;
Vet approved		 SmallMoleculeDrug DB14002 D-alpha-Tocopherol acetate Thumb


20 predicted interactions (drugs) of input target (PPP2CB): Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Experimental SmallMoleculeDrug DB06905 (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid Thumb 19.0%
2 Experimental SmallMoleculeDrug DB02379 Beta-D-Glucose Thumb 18.8%
3 Approved SmallMoleculeDrug DB00675 Tamoxifen Thumb 18.3%
4 Approved;
Investigational		 SmallMoleculeDrug DB00179 Masoprocol Thumb 18.2%
5 Approved;
Nutraceutical		 SmallMoleculeDrug DB00157 NADH Thumb 17.4%
6 Approved;
Investigational		 SmallMoleculeDrug DB11994 Diacerein Thumb 16.9%
7 Investigational SmallMoleculeDrug DB08846 Ellagic Acid Thumb 16.6%
8 Experimental SmallMoleculeDrug DB01738 Phosphorylcolamine Thumb 16.0%
9 Experimental SmallMoleculeDrug DB04185 Norvaline Thumb 15.4%
10 Approved SmallMoleculeDrug DB01094 Hesperetin Thumb 15.4%
11 Approved SmallMoleculeDrug DB09285 Morniflumate Thumb 15.1%
12 Experimental;
Investigational		 SmallMoleculeDrug DB04216 Quercetin Thumb 15.1%
13 Experimental;
Investigational		 SmallMoleculeDrug DB08838 Agmatine Thumb 15.0%
14 Experimental SmallMoleculeDrug DB02721 4-Iodopyrazole Thumb 14.6%
15 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB00744 Zileuton Thumb 14.5%
16 Nutraceutical SmallMoleculeDrug DB01892 Hyperforin Thumb 14.1%
17 Experimental SmallMoleculeDrug DB04315 Guanosine-5'-Diphosphate Thumb 14.1%
18 Experimental SmallMoleculeDrug DB01861 Uridine diphosphate glucose Thumb 13.8%
19 Investigational SmallMoleculeDrug DB06641 Perifosine Thumb 13.7%
20 Approved;
Investigational		 SmallMoleculeDrug DB00530 Erlotinib Thumb 13.6%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.