QuartataWeb
Home  |   About  |   Theory  |   Tutorials  |   FAQ  |   Bahar Lab  |   Statistics
 

Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P50406
No. Gene UniProt ID Protein Name Pathway PDB
1 HTR6 P50406 5-hydroxytryptamine receptor 6 hsa04020; hsa04024; hsa04080; hsa04726 NA


28 known interactions (drugs) of input target (HTR6): 5-hydroxytryptamine receptor 6
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb
2 Experimental;
Illicit		 SmallMoleculeDrug DB01488 Dimethyltryptamine Thumb
3 Approved SmallMoleculeDrug DB00408 Loxapine Thumb
4 Approved;
Experimental		 SmallMoleculeDrug DB13345 Dihydroergocristine Thumb
5 Approved SmallMoleculeDrug DB01224 Quetiapine Thumb
6 Approved;
Investigational		 SmallMoleculeDrug DB06148 Mianserin Thumb
7 Approved;
Investigational		 SmallMoleculeDrug DB13025 Tiapride Thumb
8 Approved SmallMoleculeDrug DB00363 Clozapine Thumb
9 Approved SmallMoleculeDrug DB04946 Iloperidone Thumb
10 Illicit;
Investigational;
Withdrawn		 SmallMoleculeDrug DB04829 Lysergic Acid Diethylamide Thumb
11 Investigational SmallMoleculeDrug DB05993 PRX-07034 Thumb
12 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB09225 Zotepine Thumb
13 Approved;
Investigational		 SmallMoleculeDrug DB01238 Aripiprazole Thumb
14 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB06144 Sertindole Thumb
15 Investigational SmallMoleculeDrug DB05042 SGS518 Thumb
16 Approved SmallMoleculeDrug DB00458 Imipramine Thumb
17 Approved SmallMoleculeDrug DB09304 Setiptiline Thumb
18 Approved;
Investigational		 SmallMoleculeDrug DB14185 Aripiprazole lauroxil Thumb
19 Investigational SmallMoleculeDrug DB06140 SUVN-502 Thumb
20 Approved SmallMoleculeDrug DB06216 Asenapine Thumb
21 Approved SmallMoleculeDrug DB11273 Dihydroergocornine Thumb
22 Approved SmallMoleculeDrug DB00246 Ziprasidone Thumb
23 Approved;
Investigational		 SmallMoleculeDrug DB01142 Doxepin Thumb
24 Approved SmallMoleculeDrug DB01049 Ergoloid mesylate Thumb
25 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00477 Chlorpromazine Thumb
26 Approved;
Investigational		 SmallMoleculeDrug DB00334 Olanzapine Thumb
27 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb
28 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb


20 predicted interactions (drugs) of input target (HTR6): 5-hydroxytryptamine receptor 6
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb 86.3%
2 Approved SmallMoleculeDrug DB00248 Cabergoline Thumb 85.0%
3 Approved SmallMoleculeDrug DB01267 Paliperidone Thumb 83.7%
4 Approved SmallMoleculeDrug DB00370 Mirtazapine Thumb 83.0%
5 Approved SmallMoleculeDrug DB06153 Pizotifen Thumb 82.9%
6 Approved;
Investigational		 SmallMoleculeDrug DB00555 Lamotrigine Thumb 82.1%
7 Approved;
Investigational		 SmallMoleculeDrug DB00934 Maprotiline Thumb 80.4%
8 Approved;
Investigational		 SmallMoleculeDrug DB01403 Methotrimeprazine Thumb 78.2%
9 Approved;
Investigational		 SmallMoleculeDrug DB00751 Epinastine Thumb 78.0%
10 Approved SmallMoleculeDrug DB00696 Ergotamine Thumb 77.9%
11 Approved;
Investigational		 SmallMoleculeDrug DB04948 Lofexidine Thumb 77.8%
12 Approved;
Investigational		 SmallMoleculeDrug DB01200 Bromocriptine Thumb 77.8%
13 Approved;
Investigational;
Vet approved;
Withdrawn		 SmallMoleculeDrug DB01186 Pergolide Thumb 77.5%
14 Approved;
Investigational		 SmallMoleculeDrug DB00734 Risperidone Thumb 77.2%
15 Approved;
Investigational		 SmallMoleculeDrug DB00714 Apomorphine Thumb 76.8%
16 Approved;
Investigational		 SmallMoleculeDrug DB01151 Desipramine Thumb 75.8%
17 Approved;
Investigational		 SmallMoleculeDrug DB00589 Lisuride Thumb 75.7%
18 Approved;
Investigational		 SmallMoleculeDrug DB00268 Ropinirole Thumb 75.6%
19 Approved;
Investigational		 SmallMoleculeDrug DB00413 Pramipexole Thumb 75.4%
20 Approved SmallMoleculeDrug DB00777 Propiomazine Thumb 75.4%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.