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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P46098
No. Gene UniProt ID Protein Name Pathway PDB
1 HTR3A P46098 5-hydroxytryptamine receptor 3A hsa04726; hsa04742 NA


43 known interactions (drugs) of input target (HTR3A): 5-hydroxytryptamine receptor 3A
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Investigational SmallMoleculeDrug DB04917 Renzapride Thumb
2 Investigational SmallMoleculeDrug DB05049 DDP733 Thumb
3 Approved;
Vet approved		 SmallMoleculeDrug DB01221 Ketamine Thumb
4 Approved SmallMoleculeDrug DB00408 Loxapine Thumb
5 Approved;
Investigational		 SmallMoleculeDrug DB01043 Memantine Thumb
6 Approved;
Withdrawn		 SmallMoleculeDrug DB00969 Alosetron Thumb
7 Approved SmallMoleculeDrug DB01224 Quetiapine Thumb
8 Approved SmallMoleculeDrug DB00898 Ethanol Thumb
9 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00721 Procaine Thumb
10 Approved;
Investigational		 SmallMoleculeDrug DB13025 Tiapride Thumb
11 Approved SmallMoleculeDrug DB00988 Dopamine Thumb
12 Approved SmallMoleculeDrug DB00904 Ondansetron Thumb
13 Approved SmallMoleculeDrug DB00333 Methadone Thumb
14 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB00604 Cisapride Thumb
15 Investigational SmallMoleculeDrug DB05642 DDP-225 Thumb
16 Approved;
Investigational		 SmallMoleculeDrug DB09068 Vortioxetine Thumb
17 Approved;
Investigational		 SmallMoleculeDrug DB09290 Ramosetron Thumb
18 Approved;
Investigational		 SmallMoleculeDrug DB01238 Aripiprazole Thumb
19 Investigational;
Nutraceutical		 SmallMoleculeDrug DB08839 Serotonin Thumb
20 Approved SmallMoleculeDrug DB01199 Tubocurarine Thumb
21 Approved;
Investigational		 SmallMoleculeDrug DB00757 Dolasetron Thumb
22 Approved SmallMoleculeDrug DB00728 Rocuronium Thumb
23 Investigational SmallMoleculeDrug DB06422 Ticalopride Thumb
24 Approved;
Investigational		 SmallMoleculeDrug DB00555 Lamotrigine Thumb
25 Approved SmallMoleculeDrug DB09304 Setiptiline Thumb
26 Approved;
Investigational		 SmallMoleculeDrug DB00889 Granisetron Thumb
27 Approved;
Investigational		 SmallMoleculeDrug DB09061 Cannabidiol Thumb
28 Approved SmallMoleculeDrug DB00363 Clozapine Thumb
29 Approved;
Investigational		 SmallMoleculeDrug DB14185 Aripiprazole lauroxil Thumb
30 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb
31 Investigational SmallMoleculeDrug DB04885 Cilansetron Thumb
32 Approved SmallMoleculeDrug DB01161 Chloroprocaine Thumb
33 Approved SmallMoleculeDrug DB11273 Dihydroergocornine Thumb
34 Approved SmallMoleculeDrug DB00246 Ziprasidone Thumb
35 Approved;
Investigational		 SmallMoleculeDrug DB11699 Tropisetron Thumb
36 Approved SmallMoleculeDrug DB00370 Mirtazapine Thumb
37 Approved SmallMoleculeDrug DB01049 Ergoloid mesylate Thumb
38 Approved SmallMoleculeDrug DB06204 Tapentadol Thumb
39 Approved;
Investigational		 SmallMoleculeDrug DB00377 Palonosetron Thumb
40 Approved;
Experimental		 SmallMoleculeDrug DB13345 Dihydroergocristine Thumb
41 Approved;
Investigational		 SmallMoleculeDrug DB00334 Olanzapine Thumb
42 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb
43 Approved;
Investigational		 SmallMoleculeDrug DB01233 Metoclopramide Thumb


20 predicted interactions (drugs) of input target (HTR3A): 5-hydroxytryptamine receptor 3A
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB00458 Imipramine Thumb 91.9%
2 Approved;
Investigational		 SmallMoleculeDrug DB06148 Mianserin Thumb 90.7%
3 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb 88.7%
4 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00477 Chlorpromazine Thumb 83.6%
5 Approved;
Investigational		 SmallMoleculeDrug DB04948 Lofexidine Thumb 80.9%
6 Approved SmallMoleculeDrug DB06153 Pizotifen Thumb 80.4%
7 Approved;
Investigational		 SmallMoleculeDrug DB00216 Eletriptan Thumb 78.8%
8 Approved;
Investigational		 SmallMoleculeDrug DB01142 Doxepin Thumb 78.7%
9 Approved;
Investigational		 SmallMoleculeDrug DB01151 Desipramine Thumb 76.7%
10 Approved SmallMoleculeDrug DB00247 Methysergide Thumb 76.6%
11 Approved;
Investigational		 SmallMoleculeDrug DB01200 Bromocriptine Thumb 76.6%
12 Approved;
Investigational		 SmallMoleculeDrug DB00934 Maprotiline Thumb 76.2%
13 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb 75.9%
14 Approved;
Investigational		 SmallMoleculeDrug DB00268 Ropinirole Thumb 75.6%
15 Approved SmallMoleculeDrug DB00248 Cabergoline Thumb 75.5%
16 Approved SmallMoleculeDrug DB00696 Ergotamine Thumb 72.4%
17 Approved;
Withdrawn		 SmallMoleculeDrug DB01149 Nefazodone Thumb 72.1%
18 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB01239 Chlorprothixene Thumb 72.0%
19 Approved SmallMoleculeDrug DB01267 Paliperidone Thumb 71.8%
20 Approved;
Investigational;
Vet approved;
Withdrawn		 SmallMoleculeDrug DB01186 Pergolide Thumb 71.4%


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.