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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P41595
No. Gene UniProt ID Protein Name Pathway PDB
1 HTR2B P41595 5-hydroxytryptamine receptor 2B hsa04020; hsa04080; hsa04540; hsa04726; hsa04750 4IB4; 4NC3


42 known interactions (drugs) of input target (HTR2B): 5-hydroxytryptamine receptor 2B
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Illicit;
Investigational;
Withdrawn		 SmallMoleculeDrug DB00574 Fenfluramine Thumb
2 Investigational SmallMoleculeDrug DB06678 Esmirtazapine Thumb
3 Approved SmallMoleculeDrug DB00696 Ergotamine Thumb
4 Approved;
Investigational		 SmallMoleculeDrug DB00714 Apomorphine Thumb
5 Approved;
Investigational		 SmallMoleculeDrug DB00589 Lisuride Thumb
6 Approved;
Vet approved		 SmallMoleculeDrug DB01221 Ketamine Thumb
7 Approved;
Investigational		 SmallMoleculeDrug DB01142 Doxepin Thumb
8 Approved;
Investigational		 SmallMoleculeDrug DB00216 Eletriptan Thumb
9 Approved;
Experimental		 SmallMoleculeDrug DB13345 Dihydroergocristine Thumb
10 Approved SmallMoleculeDrug DB00248 Cabergoline Thumb
11 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB01239 Chlorprothixene Thumb
12 Investigational SmallMoleculeDrug DB06229 Ocaperidone Thumb
13 Approved SmallMoleculeDrug DB06153 Pizotifen Thumb
14 Approved;
Investigational		 SmallMoleculeDrug DB06148 Mianserin Thumb
15 Investigational SmallMoleculeDrug DB05492 Epicept NP-1 Thumb
16 Approved;
Investigational		 SmallMoleculeDrug DB13025 Tiapride Thumb
17 Approved;
Investigational		 SmallMoleculeDrug DB00268 Ropinirole Thumb
18 Approved;
Vet approved		 SmallMoleculeDrug DB00508 Triflupromazine Thumb
19 Investigational SmallMoleculeDrug DB05607 PRX-08066 Thumb
20 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01242 Clomipramine Thumb
21 Approved SmallMoleculeDrug DB00805 Minaprine Thumb
22 Approved;
Investigational		 SmallMoleculeDrug DB09286 Pipamperone Thumb
23 Approved;
Investigational		 SmallMoleculeDrug DB01200 Bromocriptine Thumb
24 Illicit;
Investigational;
Withdrawn		 SmallMoleculeDrug DB04829 Lysergic Acid Diethylamide Thumb
25 Approved;
Investigational		 SmallMoleculeDrug DB00320 Dihydroergotamine Thumb
26 Approved SmallMoleculeDrug DB00353 Methylergometrine Thumb
27 Approved SmallMoleculeDrug DB00247 Methysergide Thumb
28 Approved;
Investigational		 SmallMoleculeDrug DB06016 Cariprazine Thumb
29 Approved SmallMoleculeDrug DB09304 Setiptiline Thumb
30 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01392 Yohimbine Thumb
31 Approved SmallMoleculeDrug DB06216 Asenapine Thumb
32 Approved SmallMoleculeDrug DB11273 Dihydroergocornine Thumb
33 Approved;
Investigational;
Vet approved;
Withdrawn		 SmallMoleculeDrug DB01186 Pergolide Thumb
34 Experimental;
Illicit;
Investigational		 SmallMoleculeDrug DB01454 Midomafetamine Thumb
35 Approved SmallMoleculeDrug DB00370 Mirtazapine Thumb
36 Approved SmallMoleculeDrug DB01049 Ergoloid mesylate Thumb
37 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00477 Chlorpromazine Thumb
38 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB01079 Tegaserod Thumb
39 Investigational SmallMoleculeDrug DB05461 OPC-28326 Thumb
40 Approved;
Investigational		 SmallMoleculeDrug DB00413 Pramipexole Thumb
41 Approved;
Investigational		 SmallMoleculeDrug DB00334 Olanzapine Thumb
42 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb


20 predicted interactions (drugs) of input target (HTR2B): 5-hydroxytryptamine receptor 2B
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB00408 Loxapine Thumb 94.0%
2 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb 93.2%
3 Approved SmallMoleculeDrug DB00363 Clozapine Thumb 91.3%
4 Approved;
Investigational		 SmallMoleculeDrug DB01238 Aripiprazole Thumb 90.9%
5 Approved SmallMoleculeDrug DB01224 Quetiapine Thumb 90.3%
6 Approved;
Investigational		 SmallMoleculeDrug DB14185 Aripiprazole lauroxil Thumb 89.7%
7 Approved SmallMoleculeDrug DB00246 Ziprasidone Thumb 89.7%
8 Approved SmallMoleculeDrug DB01267 Paliperidone Thumb 88.4%
9 Approved;
Investigational		 SmallMoleculeDrug DB00555 Lamotrigine Thumb 87.9%
10 Approved SmallMoleculeDrug DB00988 Dopamine Thumb 86.9%
11 Approved;
Investigational		 SmallMoleculeDrug DB01151 Desipramine Thumb 86.1%
12 Approved;
Investigational		 SmallMoleculeDrug DB00734 Risperidone Thumb 83.7%
13 Approved SmallMoleculeDrug DB04946 Iloperidone Thumb 83.7%
14 Approved;
Investigational		 SmallMoleculeDrug DB01403 Methotrimeprazine Thumb 83.4%
15 Approved;
Investigational		 SmallMoleculeDrug DB08815 Lurasidone Thumb 83.1%
16 Approved;
Investigational		 SmallMoleculeDrug DB00934 Maprotiline Thumb 83.1%
17 Approved;
Investigational		 SmallMoleculeDrug DB04948 Lofexidine Thumb 82.4%
18 Withdrawn SmallMoleculeDrug DB09194 Etoperidone Thumb 82.0%
19 Approved SmallMoleculeDrug DB00458 Imipramine Thumb 79.7%
20 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB06144 Sertindole Thumb 79.7%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.