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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P25100
No. Gene UniProt ID Protein Name Pathway PDB
1 ADRA1D P25100 Alpha-1D adrenergic receptor hsa04020; hsa04022; hsa04080; hsa04261; hsa04270; hsa04970 NA


68 known interactions (drugs) of input target (ADRA1D): Alpha-1D adrenergic receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved SmallMoleculeDrug DB11577 Indigotindisulfonic Acid Thumb
2 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb
3 Approved SmallMoleculeDrug DB00696 Ergotamine Thumb
4 Investigational SmallMoleculeDrug DB09204 Arotinolol Thumb
5 Approved;
Vet approved		 SmallMoleculeDrug DB00668 Epinephrine Thumb
6 Approved;
Investigational		 SmallMoleculeDrug DB00622 Nicardipine Thumb
7 Approved SmallMoleculeDrug DB00370 Mirtazapine Thumb
8 Approved SmallMoleculeDrug DB00368 Norepinephrine Thumb
9 Approved;
Investigational		 SmallMoleculeDrug DB00908 Quinidine Thumb
10 Approved;
Experimental		 SmallMoleculeDrug DB13345 Dihydroergocristine Thumb
11 Approved SmallMoleculeDrug DB00248 Cabergoline Thumb
12 Approved SmallMoleculeDrug DB01224 Quetiapine Thumb
13 Investigational SmallMoleculeDrug DB06229 Ocaperidone Thumb
14 Approved SmallMoleculeDrug DB00692 Phentolamine Thumb
15 Approved SmallMoleculeDrug DB06153 Pizotifen Thumb
16 Approved;
Investigational		 SmallMoleculeDrug DB06148 Mianserin Thumb
17 Approved;
Investigational		 SmallMoleculeDrug DB06694 Xylometazoline Thumb
18 Approved SmallMoleculeDrug DB00661 Verapamil Thumb
19 Approved;
Investigational		 SmallMoleculeDrug DB00706 Tamsulosin Thumb
20 Approved;
Investigational		 SmallMoleculeDrug DB13025 Tiapride Thumb
21 Approved SmallMoleculeDrug DB06207 Silodosin Thumb
22 Experimental SmallMoleculeDrug DB09203 Synephrine Thumb
23 Approved;
Investigational		 SmallMoleculeDrug DB01142 Doxepin Thumb
24 Approved;
Investigational		 SmallMoleculeDrug DB09286 Pipamperone Thumb
25 Approved;
Investigational		 SmallMoleculeDrug DB01200 Bromocriptine Thumb
26 Approved SmallMoleculeDrug DB01365 Mephentermine Thumb
27 Approved SmallMoleculeDrug DB00575 Clonidine Thumb
28 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb
29 Approved SmallMoleculeDrug DB00841 Dobutamine Thumb
30 Approved;
Investigational		 SmallMoleculeDrug DB00346 Alfuzosin Thumb
31 Approved SmallMoleculeDrug DB01162 Terazosin Thumb
32 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB06144 Sertindole Thumb
33 Investigational SmallMoleculeDrug DB05492 Epicept NP-1 Thumb
34 Approved;
Investigational		 SmallMoleculeDrug DB09229 Aranidipine Thumb
35 Approved SmallMoleculeDrug DB11124 Racepinephrine Thumb
36 Approved SmallMoleculeDrug DB08922 Perospirone Thumb
37 Approved SmallMoleculeDrug DB00800 Fenoldopam Thumb
38 Approved SmallMoleculeDrug DB09195 Lorpiprazole Thumb
39 Approved;
Investigational		 SmallMoleculeDrug DB00723 Methoxamine Thumb
40 Approved SmallMoleculeDrug DB00457 Prazosin Thumb
41 Approved;
Investigational		 SmallMoleculeDrug DB01136 Carvedilol Thumb
42 Approved SmallMoleculeDrug DB11273 Dihydroergocornine Thumb
43 Approved;
Investigational		 SmallMoleculeDrug DB00934 Maprotiline Thumb
44 Approved SmallMoleculeDrug DB00388 Phenylephrine Thumb
45 Approved SmallMoleculeDrug DB00211 Midodrine Thumb
46 Experimental SmallMoleculeDrug DB09202 Cirazoline Thumb
47 Approved SmallMoleculeDrug DB04855 Dronedarone Thumb
48 Approved;
Vet approved		 SmallMoleculeDrug DB00420 Promazine Thumb
49 Approved;
Investigational		 SmallMoleculeDrug DB00935 Oxymetazoline Thumb
50 Approved SmallMoleculeDrug DB09167 Dosulepin Thumb
51 Approved SmallMoleculeDrug DB00590 Doxazosin Thumb
52 Approved;
Investigational		 SmallMoleculeDrug DB09205 Moxisylyte Thumb
53 Approved;
Investigational;
Vet approved;
Withdrawn		 SmallMoleculeDrug DB01186 Pergolide Thumb
54 Approved SmallMoleculeDrug DB00458 Imipramine Thumb
55 Investigational SmallMoleculeDrug DB05469 R450 Thumb
56 Approved SmallMoleculeDrug DB01049 Ergoloid mesylate Thumb
57 Approved SmallMoleculeDrug DB00598 Labetalol Thumb
58 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00477 Chlorpromazine Thumb
59 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB00182 Amphetamine Thumb
60 Approved SmallMoleculeDrug DB11278 DL-Methylephedrine Thumb
61 Approved SmallMoleculeDrug DB00298 Dapiprazole Thumb
62 Approved SmallMoleculeDrug DB00925 Phenoxybenzamine Thumb
63 Approved;
Investigational		 SmallMoleculeDrug DB01151 Desipramine Thumb
64 Approved;
Investigational		 SmallMoleculeDrug DB01403 Methotrimeprazine Thumb
65 Approved;
Investigational		 SmallMoleculeDrug DB06262 Droxidopa Thumb
66 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb
67 Withdrawn SmallMoleculeDrug DB09194 Etoperidone Thumb
68 Approved SmallMoleculeDrug DB00777 Propiomazine Thumb


20 predicted interactions (drugs) of input target (ADRA1D): Alpha-1D adrenergic receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB00363 Clozapine Thumb 97.1%
2 Approved;
Investigational		 SmallMoleculeDrug DB00555 Lamotrigine Thumb 96.8%
3 Approved;
Investigational		 SmallMoleculeDrug DB00734 Risperidone Thumb 95.2%
4 Approved SmallMoleculeDrug DB00246 Ziprasidone Thumb 95.2%
5 Approved;
Investigational		 SmallMoleculeDrug DB01238 Aripiprazole Thumb 94.7%
6 Approved;
Withdrawn		 SmallMoleculeDrug DB00679 Thioridazine Thumb 94.3%
7 Approved SmallMoleculeDrug DB00408 Loxapine Thumb 94.1%
8 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb 94.0%
9 Approved;
Investigational		 SmallMoleculeDrug DB14185 Aripiprazole lauroxil Thumb 93.9%
10 Approved;
Investigational		 SmallMoleculeDrug DB00334 Olanzapine Thumb 93.7%
11 Approved;
Withdrawn		 SmallMoleculeDrug DB01149 Nefazodone Thumb 93.2%
12 Approved;
Vet approved		 SmallMoleculeDrug DB01614 Acepromazine Thumb 92.2%
13 Approved SmallMoleculeDrug DB01267 Paliperidone Thumb 91.6%
14 Approved SmallMoleculeDrug DB01622 Thioproperazine Thumb 90.3%
15 Approved;
Illicit		 SmallMoleculeDrug DB01579 Phendimetrazine Thumb 90.0%
16 Approved;
Investigational		 SmallMoleculeDrug DB09128 Brexpiprazole Thumb 89.7%
17 Approved;
Illicit		 SmallMoleculeDrug DB01576 Dextroamphetamine Thumb 89.3%
18 Approved SmallMoleculeDrug DB04946 Iloperidone Thumb 88.5%
19 Approved SmallMoleculeDrug DB06216 Asenapine Thumb 88.0%
20 Approved;
Investigational		 SmallMoleculeDrug DB01608 Propericiazine Thumb 86.3%


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.